Mason Sweat

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1. [1]

   Mason Sweat, Ph.D. - Faculty Profile - UT Southwestern

   15 source claims · Reviewed Sep 7, 2026

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   Biographical context: His research spans developmental biology, molecular genetics, and cardiovascular science, with work on TBX5, CHD4, chamber-specific gene regulation, cardiac arrhythmia, and cardiomyocyte identity.

   Biography Download Curriculum Vitae Mason Sweat, Ph.D., is an Assistant Professor in the Department of Internal Medicine at UT Southwestern Medical Center and a member of its Division of Cardiology. Originally from Iowa City, Iowa, Dr. Sweat holds a bacheor's degree in biology (neurobiology) with a minor in chemistry from the University of Iowa, where he also earned his doctoral degree in cell and developmental biology. He then completed postdoctoral training in the lab of William Pu, M.D., at Boston Children's Hospital and Harvard Medical School, where he developed expertise in cardiac biology. He joined the UT Southwestern faculty in 2025. Dr. Sweat's research spans developmental biology, molecular genetics, and cardiovascular science, with a strong focus on transcriptional and epigenetic regulation in organogenesis and cardiac physiology. His early work explored craniofacial development, stem cell renewal, and signaling pathways such as Wnt, Hippo, and microRNA networks in ectodermal organ formation. He investigated key regulators like Sox2, Lef-1, Pitx2, and KLF4, elucidating mechanisms underlying dental morphogenesis and palatogenesis. Transitioning to cardiovascular research, Dr. Sweat has advanced understanding of cardiac identity and rhythm homeostasis, particularly through enhancer networks and transcription factors such as TBX5 and CHD4. His studies dissect chamber-specific gene regulation, atrial cardiomyocyte maintenance, and molecular determinants of atrial fibrillation, integrating multi-omics approaches and translational strategies like antisense oligonucleotide therapy. Collectively, his work bridges developmental genetics and cardiac disease, aiming to uncover therapeutic targets for structural and rhythm disorders. Dr. Sweat has authored numerous peer-reviewed publications in high-impact journals, including Nature Cardiovascular Research and Circulation. His work has been supported by multiple NIH NHLBI grant mechanisms, including an F32 postdoctoral fellowship and the K99/R00 pathway to independence research award. An active member of the American Heart Association, Dr. Sweat also contributes to the scientific community through leadership roles, including serving as Co-Chair for the Gordon Research Seminar on Cardiac Regulatory Mechanisms.

   Biographical context: Mason Sweat studies transcriptional and epigenetic control of cardiac identity and rhythm, including atrial cardiomyocyte maintenance and molecular mechanisms of atrial fibrillation. His work connects developmental genetics, enhancer networks, multi-omics, and therapeutic strategies such as antisense oligonucleotides.

   Biography Download Curriculum Vitae Mason Sweat, Ph.D., is an Assistant Professor in the Department of Internal Medicine at UT Southwestern Medical Center and a member of its Division of Cardiology. Originally from Iowa City, Iowa, Dr. Sweat holds a bacheor's degree in biology (neurobiology) with a minor in chemistry from the University of Iowa, where he also earned his doctoral degree in cell and developmental biology. He then completed postdoctoral training in the lab of William Pu, M.D., at Boston Children's Hospital and Harvard Medical School, where he developed expertise in cardiac biology. He joined the UT Southwestern faculty in 2025. Dr. Sweat's research spans developmental biology, molecular genetics, and cardiovascular science, with a strong focus on transcriptional and epigenetic regulation in organogenesis and cardiac physiology. His early work explored craniofacial development, stem cell renewal, and signaling pathways such as Wnt, Hippo, and microRNA networks in ectodermal organ formation. He investigated key regulators like Sox2, Lef-1, Pitx2, and KLF4, elucidating mechanisms underlying dental morphogenesis and palatogenesis. Transitioning to cardiovascular research, Dr. Sweat has advanced understanding of cardiac identity and rhythm homeostasis, particularly through enhancer networks and transcription factors such as TBX5 and CHD4. His studies dissect chamber-specific gene regulation, atrial cardiomyocyte maintenance, and molecular determinants of atrial fibrillation, integrating multi-omics approaches and translational strategies like antisense oligonucleotide therapy. Collectively, his work bridges developmental genetics and cardiac disease, aiming to uncover therapeutic targets for structural and rhythm disorders. Dr. Sweat has authored numerous peer-reviewed publications in high-impact journals, including Nature Cardiovascular Research and Circulation. His work has been supported by multiple NIH NHLBI grant mechanisms, including an F32 postdoctoral fellowship and the K99/R00 pathway to independence research award. An active member of the American Heart Association, Dr. Sweat also contributes to the scientific community through leadership roles, including serving as Co-Chair for the Gordon Research Seminar on Cardiac Regulatory Mechanisms.

   Biographical context: Sweat earned his doctorate in cell and developmental biology at the University of Iowa and completed postdoctoral training in William Pu's laboratory at Boston Children's Hospital and Harvard Medical School. He joined UT Southwestern in 2025.

   Biography Download Curriculum Vitae Mason Sweat, Ph.D., is an Assistant Professor in the Department of Internal Medicine at UT Southwestern Medical Center and a member of its Division of Cardiology. Originally from Iowa City, Iowa, Dr. Sweat holds a bacheor's degree in biology (neurobiology) with a minor in chemistry from the University of Iowa, where he also earned his doctoral degree in cell and developmental biology. He then completed postdoctoral training in the lab of William Pu, M.D., at Boston Children's Hospital and Harvard Medical School, where he developed expertise in cardiac biology. He joined the UT Southwestern faculty in 2025. Dr. Sweat's research spans developmental biology, molecular genetics, and cardiovascular science, with a strong focus on transcriptional and epigenetic regulation in organogenesis and cardiac physiology. His early work explored craniofacial development, stem cell renewal, and signaling pathways such as Wnt, Hippo, and microRNA networks in ectodermal organ formation. He investigated key regulators like Sox2, Lef-1, Pitx2, and KLF4, elucidating mechanisms underlying dental morphogenesis and palatogenesis. Transitioning to cardiovascular research, Dr. Sweat has advanced understanding of cardiac identity and rhythm homeostasis, particularly through enhancer networks and transcription factors such as TBX5 and CHD4. His studies dissect chamber-specific gene regulation, atrial cardiomyocyte maintenance, and molecular determinants of atrial fibrillation, integrating multi-omics approaches and translational strategies like antisense oligonucleotide therapy. Collectively, his work bridges developmental genetics and cardiac disease, aiming to uncover therapeutic targets for structural and rhythm disorders. Dr. Sweat has authored numerous peer-reviewed publications in high-impact journals, including Nature Cardiovascular Research and Circulation. His work has been supported by multiple NIH NHLBI grant mechanisms, including an F32 postdoctoral fellowship and the K99/R00 pathway to independence research award. An active member of the American Heart Association, Dr. Sweat also contributes to the scientific community through leadership roles, including serving as Co-Chair for the Gordon Research Seminar on Cardiac Regulatory Mechanisms.

   Education record: Boston Children's Hospital and Harvard Medical School (Cardiac biology in William Pu's laboratory)

   Originally from Iowa City, Iowa, Dr. Sweat holds a bacheor's degree in biology (neurobiology) with a minor in chemistry from the University of Iowa, where he also earned his doctoral degree in cell and developmental biology. He then completed postdoctoral training in the lab of William Pu, M.D., at Boston Children's Hospital and Harvard Medical School, where he developed expertise in cardiac biology.

   Graduate education: University of Iowa (Graduate school; biography identifies a Ph.D. in cell and developmental biology)

   Through 2020

   Originally from Iowa City, Iowa, Dr. Sweat holds a bacheor's degree in biology (neurobiology) with a minor in chemistry from the University of Iowa, where he also earned his doctoral degree in cell and developmental biology. He then completed postdoctoral training in the lab of William Pu, M.D., at Boston Children's Hospital and Harvard Medical School, where he developed expertise in cardiac biology.

   Official headshot: Portrait

   <img src="https://profileplus.swmed.edu/facultydata/239801/images/sweat-mason-inset.jpg" class="card__image" itemprop="image" alt="Mason Sweat, Ph.D. " style="max-width:200px;" />

   Official profile: Official profile

   Biography Download Curriculum Vitae Mason Sweat, Ph.D., is an Assistant Professor in the Department of Internal Medicine at UT Southwestern Medical Center and a member of its Division of Cardiology. Originally from Iowa City, Iowa, Dr. Sweat holds a bacheor's degree in biology (neurobiology) with a minor in chemistry from the University of Iowa, where he also earned his doctoral degree in cell and developmental biology. He then completed postdoctoral training in the lab of William Pu, M.D., at Boston Children's Hospital and Harvard Medical School, where he developed expertise in cardiac biology. He joined the UT Southwestern faculty in 2025. Dr. Sweat's research spans developmental biology, molecular genetics, and cardiovascular science, with a strong focus on transcriptional and epigenetic regulation in organogenesis and cardiac physiology. His early work explored craniofacial development, stem cell renewal, and signaling pathways such as Wnt, Hippo, and microRNA networks in ectodermal organ formation. He investigated key regulators like Sox2, Lef-1, Pitx2, and KLF4, elucidating mechanisms underlying dental morphogenesis and palatogenesis. Transitioning to cardiovascular research, Dr. Sweat has advanced understanding of cardiac identity and rhythm homeostasis, particularly through enhancer networks and transcription factors such as TBX5 and CHD4. His studies dissect chamber-specific gene regulation, atrial cardiomyocyte maintenance, and molecular determinants of atrial fibrillation, integrating multi-omics approaches and translational strategies like antisense oligonucleotide therapy. Collectively, his work bridges developmental genetics and cardiac disease, aiming to uncover therapeutic targets for structural and rhythm disorders. Dr. Sweat has authored numerous peer-reviewed publications in high-impact journals, including Nature Cardiovascular Research and Circulation. His work has been supported by multiple NIH NHLBI grant mechanisms, including an F32 postdoctoral fellowship and the K99/R00 pathway to independence research award. An active member of the American Heart Association, Dr. Sweat also contributes to the scientific community through leadership roles, including serving as Co-Chair for the Gordon Research Seminar on Cardiac Regulatory Mechanisms.

   Research interests: atrial fibrillation

   Research Interest Atrial Fibrillation Cardiac Arrhythmia Cardiomyocyte Identity Mechanisms

   Research interests: cardiac arrhythmia

   Research Interest Atrial Fibrillation Cardiac Arrhythmia Cardiomyocyte Identity Mechanisms

   Research interests: cardiomyocyte identity

   Research Interest Atrial Fibrillation Cardiac Arrhythmia Cardiomyocyte Identity Mechanisms

   Research interests: developmental genetics

   Research Interest Atrial Fibrillation Cardiac Arrhythmia Cardiomyocyte Identity Mechanisms

   Research interests: enhancer networks

   Research Interest Atrial Fibrillation Cardiac Arrhythmia Cardiomyocyte Identity Mechanisms

   Research interests: epigenetic regulation

   Research Interest Atrial Fibrillation Cardiac Arrhythmia Cardiomyocyte Identity Mechanisms

   Research interests: multi-omics

   Research Interest Atrial Fibrillation Cardiac Arrhythmia Cardiomyocyte Identity Mechanisms

   Research interests: transcriptional regulation

   Research Interest Atrial Fibrillation Cardiac Arrhythmia Cardiomyocyte Identity Mechanisms

2. [2]

   UT Southwestern Division of Cardiology faculty directory

   1 source claim · Reviewed Sep 7, 2026

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   Professional role: Assistant Professor

   Mason Sweat, Ph.D. Assistant Professor