Sudha Kaup Shenoy

Publication: “Emerging roles of ubiquitin-specific proteases in the cardiovascular system.”

Publication: “How carvedilol does not activate β2-adrenoceptors.”

Publication: “Inflammation-induced endothelial cell activation and angiogenic sprouting are downmodulated by ubiquitin-specific peptidase 20.”

Publication: “Phosphorylation of USP20 on Ser334 by IRAK1 promotes IL-1β-evoked signaling in vascular smooth muscle cells and vascular inflammation.”

Publication: “Small-molecule modulation of β-arrestins.”

Publication: “The ubiquitination status of the glucagon receptor determines signal bias.”

Publication: “USP20 deletion promotes eccentric cardiac remodeling in response to pressure overload and increases mortality.”

Publication: “β-adrenergic receptor signaling mediated by β-arrestins and its potential role in heart failure.”

Sudha Kaup Shenoy is a Duke faculty leader whose research connects GPCR signaling, ubiquitination, and cardiovascular disease. She is Professor in Medicine and Cell Biology and a member of the Duke Cancer Institute. After earning a Ph.D. from Oklahoma State University in 1998, she completed postdoctoral training with Robert J. Lefkowitz at Duke. Her postdoctoral work distinguished ubiquitination mechanisms that direct GPCs and β-arrestin toward different trafficking outcomes. Her laboratory studies ubiquitin-code mechanisms in GPCRs and β-arrestins, including USP20 and USP33 regulation of signaling in the heart and vascular endothelium. Her interests also include glucagon-receptor signaling bias, diabetes, cardiac remodeling, and potential therapeutic modulation. She was the first recipient of Duke’s Headley Family Award for cardiovascular research.