Professional role
Assistant Professor, Department of Pathology, School of Medicine[1]
SL
I engineered dimeric IgA monoclonal antibodies that could passively transfer into the breast milk of lactating mice and protect against rotavirus disease in suckling neonates.
My graduate work in the laboratory of Dr. Linda Saif, member of the National Academy of Sciences, provided me with strong training in mucosal viral immunology.
Throughout my graduate and postgraduate years, I have developed a strong background in virology, mucosal immunology, and infectious diseases.
Mucosal antibody immunobiology in the female reproductive tract · Mucosal immune protection against infectious diseases, particularly in women and children. · Our research team is particularly interested in B cells that reside in mucosal tissues and the antibodies they produce that end up at mucosal surfaces, interacting with both pathogens and microbiota. · Specifically, we are focused on understanding immunoglobulin A (IgA) in all of its forms (monomers, dimers, and secretory) and are designing and testing therapeutic strategies that boost IgA antibodies at mucosal surfaces to inhibit virus replication and transmission, stabilize the microbiota, or all the above!
Reviewed sources document Education record: Ohio State University Animal Sciences, Life Sciences ( with Research Distinction) 2011, Education record: Ohio State University Virology, Immunology 2018, Education record: postdoctoral training, and Education record: Virginia Polytechnic and State University (Virginia Tech) Immunology 2013.
Explore education and trainingReviewed sources document Mucosal antibody immunobiology in the female reproductive tract, Mucosal immune protection against infectious diseases, particularly in women and children., Our research team is particularly interested in B cells that reside in mucosal tissues and the antibodies they produce that end up at mucosal surfaces, interacting with both pathogens and microbiota., and Specifically, we are focused on understanding immunoglobulin A (IgA) in all of its forms (monomers, dimers, and secretory) and are designing and testing therapeutic strategies that boost IgA antibodies at mucosal surfaces to inhibit virus replication and transmission, stabilize the microbiota, or all the above!. Explore attributed publications and research affiliations.
Explore researchAssistant Professor, Department of Pathology, School of Medicine[1]
Member, Center for Global Health and Diseases, School of Medicine[1]
My research during my postdoctoral training in Dr. Sallie Permar’s lab at the Duke Human Vaccine Institute further expanded my knowledge of the biology of IgA antibodies, the most dominant antibody at most mucosal surfaces. I engineered dimeric IgA monoclonal antibodies that could passively transfer into the breast milk of lactating mice and protect against rotavirus disease in suckling neonates. My background studying mucosal antibody responses led to a Bill and Melinda Gates Foundation grant (PI: S. Langel) to study mucosal immunization strategies to generate neutralizing antibodies at mucosal surfaces that protect against influenza or SARS-CoV-2. During this time, I transitioned to a Medical Instructor (non-tenure track faculty) position within the lab of Dr. Georgia Tomaras. Within the Tomaras lab, I was integrated into her influenza team (funded by the Duke Center for Influenza Vaccinate Innovation Center) where we optimized and validated antigen binding, hemagglutinin inhibition and microneutralization assays for the detection of anti-influenza antibodies.[1]
Ohio State University Animal Sciences, Life Sciences ( with Research Distinction) 2011[1]
Ohio State University Virology, Immunology 2018[1]
postdoctoral training[1]
Virginia Polytechnic and State University (Virginia Tech) Immunology 2013[1]
Mucosal antibody immunobiology in the female reproductive tract[1]
Mucosal immune protection against infectious diseases, particularly in women and children.[1]
Our research team is particularly interested in B cells that reside in mucosal tissues and the antibodies they produce that end up at mucosal surfaces, interacting with both pathogens and microbiota.[1]
Specifically, we are focused on understanding immunoglobulin A (IgA) in all of its forms (monomers, dimers, and secretory) and are designing and testing therapeutic strategies that boost IgA antibodies at mucosal surfaces to inhibit virus replication and transmission, stabilize the microbiota, or all the above![1]
Sources are listed once and connected to each accepted claim they support. Excerpts preserve the source language used in the review.
20 source claims · Reviewed Sep 9, 2026
Biographical context: I engineered dimeric IgA monoclonal antibodies that could passively transfer into the breast milk of lactating mice and protect against rotavirus disease in suckling neonates.
Stephanie Langel, PhD Email [contact withheld] Phone [contact withheld] Office Location: Biomedical Research Building 2109 Adelbert Rd. Ofc. 424 Cleveland, Ohio 44106 Assistant Professor, Department of Pathology, School of Medicine Member, Center for Global Health and Diseases, School of Medicine Our dynamic research team is dedicated to understanding our immune responses at mucosal surfaces. Mucosal immune responses protect us against invading pathogens and environmental irritants but also tolerate and are shaped by our commensal microbiota - billions of bacteria, fungi, and viruses living within us. Our research team is particularly interested in B cells that reside in mucosal tissues and the antibodies they produce that end up at mucosal surfaces, interacting with both pathogens and microbiota. Specifically, we are focused on understanding immunoglobulin A (IgA) in all of its forms (monomers, dimers, and secretory) and are designing and testing therapeutic strategies that boost IgA antibodies at mucosal surfaces to inhibit virus replication and transmission, stabilize the microbiota, or all the above! Moms and babies: As a research team, we have a specific interest in the immune responses of moms and babies. We are working to understand better how maternal B cells and antibodies shape maternal and neonatal immune responses. Specifically, we are interested in the mucosal-mammary gland axis where plasma cells (mostly IgA) from mom’s mucosal tissues migrate to the mammary gland to secrete antibodies in milk. This evolutionary cross-talk allows antibacterial and antiviral antibodies that function in mom to contribute to protection and immune development in the suckling infant. Current projects in our lab involve designing immunization strategies that boost breast milk immunity against many viruses, including influenza viruses, rotaviruses, and norovirus. We are using single-cell technologies, animal models, and human clinical samples to accomplish this. Our lab is currently focused on four main areas Maternal immunization and lactogenic immunity Mechanisms of maternal antibody interference Mucosal immunization and airborne transmission of respiratory viruses Mucosal antibody immunobiology The Langel lab is focused on understanding antibody and B cell responses to viral infections, particularly during pregnancy and lactation. To accomplish this, the Langel lab is using single cell technologies, translational animal models, and human clinical samples. The Langel lab's overall goal is to improve maternal and neonatal health around the world. Stephanie Langel's Biography Research Information Research Interests Mucosal immune protection against infectious diseases, particularly in women and children. Research Projects Maternal immunization and lactogenic immunity Mechanisms of maternal antibody interference Mucosal immunization and airborne transmission of respiratory viruses Mucosal antibody immunobiology in the female reproductive tract Awards and Honors Seed fund awardee 2022 The Hypothesis Fund College of Food, Agricultural and Environmental Sciences Distinguished Alumni Award 2022 The Ohio State University Selected for Impact Talk 2021 Duke Center for AIDS Research (CFAR) Annual Research Retreat Student Registration Award 2021 American Society for Virology Annual Conference ‘Basic and Translational Research’ Top 5 abstract 2021 Duke Pediatrics Research Retreat Derfner Foundation Award 2020 Children’s Hospital Miracle Network, Duke Department of Pediatrics Travel scholarship 2020 ‘Antibodies as Drugs: from B cell biology to new treatments’ Keystone meeting, Santa Fe, NM Abstract selected for an oral presentation 2020 ‘Antibodies as Drugs: from B cell biology to new treatments’ Keystone meeting, Santa Fe, NM Postdoctoral poster presentation award 2019 Department of Molecular Genetics and Microbiology retreat, Duke University Travel Award 2018 American Society for Virology Annual Meeting Professional Memberships Society for Mucosal Immunology American Society for Virology American Association of Immunologists Publications https://pubmed.ncbi.nlm.nih.gov/?term=langel+sn&sort=date Education PhD Ohio State University Virology, Immunology 2018 Master of Science Virginia Polytechnic and State University (Virginia Tech) Immunology 2013 Bachelor of Science Ohio State University Animal Sciences, Life Sciences ( with Research Distinction) 2011 Additional Information Personal Statement I have studied mucosal antibody responses for 10 years, and have developed an interdisciplinary combination of knowledge, experience, and skill for assessing antibody function during different disease states. My graduate work in the laboratory of Dr. Linda Saif, member of the National Academy of Sciences, provided me with strong training in mucosal viral immunology. Specifically, I studied the mucosal immune response to a novel enteric coronavirus in pregnant and lactating swine. I discovered the role of intestinal IgA plasma cells that traffic to the mammary gland and secrete IgA into breast milk and protect neonates against coronavirus challenge. Additionally, I worked extensively with gnotobiotic piglets to study the role of probiotic bacteria in immunomodulation of the intestinal antibody response against rotavirus immunization and infection. My research during my postdoctoral training in Dr. Sallie Permar’s lab at the Duke Human Vaccine Institute further expanded my knowledge of the biology of IgA antibodies, the most dominant antibody at most mucosal surfaces. I engineered dimeric IgA monoclonal antibodies that could passively transfer into the breast milk of lactating mice and protect against rotavirus disease in suckling neonates. My background studying mucosal antibody responses led to a Bill and Melinda Gates Foundation grant (PI: S. Langel) to study mucosal immunization strategies to generate neutralizing antibodies at mucosal surfaces that protect against influenza or SARS-CoV-2. During this time, I transitioned to a Medical Instructor (non-tenure track faculty) position within the lab of Dr. Georgia Tomaras. Within the Tomaras lab, I was integrated into her influenza team (funded by the Duke Center for Influenza Vaccinate Innovation Center) where we optimized and validated antigen binding, hemagglutinin inhibition and microneutralization assays for the detection of anti-influenza antibodies. Throughout my graduate and postgraduate years, I have developed a strong background in virology, mucosal immunology, and infectious diseases. I have demonstrated an ability to optimize and validate assays for the functional characterization of antibodies against multiple pathogens. These experiences reflect the work my lab is currently doing to better understand B cell and antibody biology at mucosal surfaces. My background studying antibody function during multiple different disease states makes my lab uniquely capable to explore mucosal immunity to viral infections at the maternal/neonatal interface and in the female reproductive tract. Website Langel Research Team
Biographical context: My graduate work in the laboratory of Dr. Linda Saif, member of the National Academy of Sciences, provided me with strong training in mucosal viral immunology.
Stephanie Langel, PhD Email [contact withheld] Phone [contact withheld] Office Location: Biomedical Research Building 2109 Adelbert Rd. Ofc. 424 Cleveland, Ohio 44106 Assistant Professor, Department of Pathology, School of Medicine Member, Center for Global Health and Diseases, School of Medicine Our dynamic research team is dedicated to understanding our immune responses at mucosal surfaces. Mucosal immune responses protect us against invading pathogens and environmental irritants but also tolerate and are shaped by our commensal microbiota - billions of bacteria, fungi, and viruses living within us. Our research team is particularly interested in B cells that reside in mucosal tissues and the antibodies they produce that end up at mucosal surfaces, interacting with both pathogens and microbiota. Specifically, we are focused on understanding immunoglobulin A (IgA) in all of its forms (monomers, dimers, and secretory) and are designing and testing therapeutic strategies that boost IgA antibodies at mucosal surfaces to inhibit virus replication and transmission, stabilize the microbiota, or all the above! Moms and babies: As a research team, we have a specific interest in the immune responses of moms and babies. We are working to understand better how maternal B cells and antibodies shape maternal and neonatal immune responses. Specifically, we are interested in the mucosal-mammary gland axis where plasma cells (mostly IgA) from mom’s mucosal tissues migrate to the mammary gland to secrete antibodies in milk. This evolutionary cross-talk allows antibacterial and antiviral antibodies that function in mom to contribute to protection and immune development in the suckling infant. Current projects in our lab involve designing immunization strategies that boost breast milk immunity against many viruses, including influenza viruses, rotaviruses, and norovirus. We are using single-cell technologies, animal models, and human clinical samples to accomplish this. Our lab is currently focused on four main areas Maternal immunization and lactogenic immunity Mechanisms of maternal antibody interference Mucosal immunization and airborne transmission of respiratory viruses Mucosal antibody immunobiology The Langel lab is focused on understanding antibody and B cell responses to viral infections, particularly during pregnancy and lactation. To accomplish this, the Langel lab is using single cell technologies, translational animal models, and human clinical samples. The Langel lab's overall goal is to improve maternal and neonatal health around the world. Stephanie Langel's Biography Research Information Research Interests Mucosal immune protection against infectious diseases, particularly in women and children. Research Projects Maternal immunization and lactogenic immunity Mechanisms of maternal antibody interference Mucosal immunization and airborne transmission of respiratory viruses Mucosal antibody immunobiology in the female reproductive tract Awards and Honors Seed fund awardee 2022 The Hypothesis Fund College of Food, Agricultural and Environmental Sciences Distinguished Alumni Award 2022 The Ohio State University Selected for Impact Talk 2021 Duke Center for AIDS Research (CFAR) Annual Research Retreat Student Registration Award 2021 American Society for Virology Annual Conference ‘Basic and Translational Research’ Top 5 abstract 2021 Duke Pediatrics Research Retreat Derfner Foundation Award 2020 Children’s Hospital Miracle Network, Duke Department of Pediatrics Travel scholarship 2020 ‘Antibodies as Drugs: from B cell biology to new treatments’ Keystone meeting, Santa Fe, NM Abstract selected for an oral presentation 2020 ‘Antibodies as Drugs: from B cell biology to new treatments’ Keystone meeting, Santa Fe, NM Postdoctoral poster presentation award 2019 Department of Molecular Genetics and Microbiology retreat, Duke University Travel Award 2018 American Society for Virology Annual Meeting Professional Memberships Society for Mucosal Immunology American Society for Virology American Association of Immunologists Publications https://pubmed.ncbi.nlm.nih.gov/?term=langel+sn&sort=date Education PhD Ohio State University Virology, Immunology 2018 Master of Science Virginia Polytechnic and State University (Virginia Tech) Immunology 2013 Bachelor of Science Ohio State University Animal Sciences, Life Sciences ( with Research Distinction) 2011 Additional Information Personal Statement I have studied mucosal antibody responses for 10 years, and have developed an interdisciplinary combination of knowledge, experience, and skill for assessing antibody function during different disease states. My graduate work in the laboratory of Dr. Linda Saif, member of the National Academy of Sciences, provided me with strong training in mucosal viral immunology. Specifically, I studied the mucosal immune response to a novel enteric coronavirus in pregnant and lactating swine. I discovered the role of intestinal IgA plasma cells that traffic to the mammary gland and secrete IgA into breast milk and protect neonates against coronavirus challenge. Additionally, I worked extensively with gnotobiotic piglets to study the role of probiotic bacteria in immunomodulation of the intestinal antibody response against rotavirus immunization and infection. My research during my postdoctoral training in Dr. Sallie Permar’s lab at the Duke Human Vaccine Institute further expanded my knowledge of the biology of IgA antibodies, the most dominant antibody at most mucosal surfaces. I engineered dimeric IgA monoclonal antibodies that could passively transfer into the breast milk of lactating mice and protect against rotavirus disease in suckling neonates. My background studying mucosal antibody responses led to a Bill and Melinda Gates Foundation grant (PI: S. Langel) to study mucosal immunization strategies to generate neutralizing antibodies at mucosal surfaces that protect against influenza or SARS-CoV-2. During this time, I transitioned to a Medical Instructor (non-tenure track faculty) position within the lab of Dr. Georgia Tomaras. Within the Tomaras lab, I was integrated into her influenza team (funded by the Duke Center for Influenza Vaccinate Innovation Center) where we optimized and validated antigen binding, hemagglutinin inhibition and microneutralization assays for the detection of anti-influenza antibodies. Throughout my graduate and postgraduate years, I have developed a strong background in virology, mucosal immunology, and infectious diseases. I have demonstrated an ability to optimize and validate assays for the functional characterization of antibodies against multiple pathogens. These experiences reflect the work my lab is currently doing to better understand B cell and antibody biology at mucosal surfaces. My background studying antibody function during multiple different disease states makes my lab uniquely capable to explore mucosal immunity to viral infections at the maternal/neonatal interface and in the female reproductive tract. Website Langel Research Team
Biographical context: Throughout my graduate and postgraduate years, I have developed a strong background in virology, mucosal immunology, and infectious diseases.
Stephanie Langel, PhD Email [contact withheld] Phone [contact withheld] Office Location: Biomedical Research Building 2109 Adelbert Rd. Ofc. 424 Cleveland, Ohio 44106 Assistant Professor, Department of Pathology, School of Medicine Member, Center for Global Health and Diseases, School of Medicine Our dynamic research team is dedicated to understanding our immune responses at mucosal surfaces. Mucosal immune responses protect us against invading pathogens and environmental irritants but also tolerate and are shaped by our commensal microbiota - billions of bacteria, fungi, and viruses living within us. Our research team is particularly interested in B cells that reside in mucosal tissues and the antibodies they produce that end up at mucosal surfaces, interacting with both pathogens and microbiota. Specifically, we are focused on understanding immunoglobulin A (IgA) in all of its forms (monomers, dimers, and secretory) and are designing and testing therapeutic strategies that boost IgA antibodies at mucosal surfaces to inhibit virus replication and transmission, stabilize the microbiota, or all the above! Moms and babies: As a research team, we have a specific interest in the immune responses of moms and babies. We are working to understand better how maternal B cells and antibodies shape maternal and neonatal immune responses. Specifically, we are interested in the mucosal-mammary gland axis where plasma cells (mostly IgA) from mom’s mucosal tissues migrate to the mammary gland to secrete antibodies in milk. This evolutionary cross-talk allows antibacterial and antiviral antibodies that function in mom to contribute to protection and immune development in the suckling infant. Current projects in our lab involve designing immunization strategies that boost breast milk immunity against many viruses, including influenza viruses, rotaviruses, and norovirus. We are using single-cell technologies, animal models, and human clinical samples to accomplish this. Our lab is currently focused on four main areas Maternal immunization and lactogenic immunity Mechanisms of maternal antibody interference Mucosal immunization and airborne transmission of respiratory viruses Mucosal antibody immunobiology The Langel lab is focused on understanding antibody and B cell responses to viral infections, particularly during pregnancy and lactation. To accomplish this, the Langel lab is using single cell technologies, translational animal models, and human clinical samples. The Langel lab's overall goal is to improve maternal and neonatal health around the world. Stephanie Langel's Biography Research Information Research Interests Mucosal immune protection against infectious diseases, particularly in women and children. Research Projects Maternal immunization and lactogenic immunity Mechanisms of maternal antibody interference Mucosal immunization and airborne transmission of respiratory viruses Mucosal antibody immunobiology in the female reproductive tract Awards and Honors Seed fund awardee 2022 The Hypothesis Fund College of Food, Agricultural and Environmental Sciences Distinguished Alumni Award 2022 The Ohio State University Selected for Impact Talk 2021 Duke Center for AIDS Research (CFAR) Annual Research Retreat Student Registration Award 2021 American Society for Virology Annual Conference ‘Basic and Translational Research’ Top 5 abstract 2021 Duke Pediatrics Research Retreat Derfner Foundation Award 2020 Children’s Hospital Miracle Network, Duke Department of Pediatrics Travel scholarship 2020 ‘Antibodies as Drugs: from B cell biology to new treatments’ Keystone meeting, Santa Fe, NM Abstract selected for an oral presentation 2020 ‘Antibodies as Drugs: from B cell biology to new treatments’ Keystone meeting, Santa Fe, NM Postdoctoral poster presentation award 2019 Department of Molecular Genetics and Microbiology retreat, Duke University Travel Award 2018 American Society for Virology Annual Meeting Professional Memberships Society for Mucosal Immunology American Society for Virology American Association of Immunologists Publications https://pubmed.ncbi.nlm.nih.gov/?term=langel+sn&sort=date Education PhD Ohio State University Virology, Immunology 2018 Master of Science Virginia Polytechnic and State University (Virginia Tech) Immunology 2013 Bachelor of Science Ohio State University Animal Sciences, Life Sciences ( with Research Distinction) 2011 Additional Information Personal Statement I have studied mucosal antibody responses for 10 years, and have developed an interdisciplinary combination of knowledge, experience, and skill for assessing antibody function during different disease states. My graduate work in the laboratory of Dr. Linda Saif, member of the National Academy of Sciences, provided me with strong training in mucosal viral immunology. Specifically, I studied the mucosal immune response to a novel enteric coronavirus in pregnant and lactating swine. I discovered the role of intestinal IgA plasma cells that traffic to the mammary gland and secrete IgA into breast milk and protect neonates against coronavirus challenge. Additionally, I worked extensively with gnotobiotic piglets to study the role of probiotic bacteria in immunomodulation of the intestinal antibody response against rotavirus immunization and infection. My research during my postdoctoral training in Dr. Sallie Permar’s lab at the Duke Human Vaccine Institute further expanded my knowledge of the biology of IgA antibodies, the most dominant antibody at most mucosal surfaces. I engineered dimeric IgA monoclonal antibodies that could passively transfer into the breast milk of lactating mice and protect against rotavirus disease in suckling neonates. My background studying mucosal antibody responses led to a Bill and Melinda Gates Foundation grant (PI: S. Langel) to study mucosal immunization strategies to generate neutralizing antibodies at mucosal surfaces that protect against influenza or SARS-CoV-2. During this time, I transitioned to a Medical Instructor (non-tenure track faculty) position within the lab of Dr. Georgia Tomaras. Within the Tomaras lab, I was integrated into her influenza team (funded by the Duke Center for Influenza Vaccinate Innovation Center) where we optimized and validated antigen binding, hemagglutinin inhibition and microneutralization assays for the detection of anti-influenza antibodies. Throughout my graduate and postgraduate years, I have developed a strong background in virology, mucosal immunology, and infectious diseases. I have demonstrated an ability to optimize and validate assays for the functional characterization of antibodies against multiple pathogens. These experiences reflect the work my lab is currently doing to better understand B cell and antibody biology at mucosal surfaces. My background studying antibody function during multiple different disease states makes my lab uniquely capable to explore mucosal immunity to viral infections at the maternal/neonatal interface and in the female reproductive tract. Website Langel Research Team
Degree: Bachelor of Science
Stephanie Langel, PhD Email [contact withheld] Phone [contact withheld] Office Location: Biomedical Research Building 2109 Adelbert Rd. Ofc. 424 Cleveland, Ohio 44106 Assistant Professor, Department of Pathology, School of Medicine Member, Center for Global Health and Diseases, School of Medicine Our dynamic research team is dedicated to understanding our immune responses at mucosal surfaces. Mucosal immune responses protect us against invading pathogens and environmental irritants but also tolerate and are shaped by our commensal microbiota - billions of bacteria, fungi, and viruses living within us. Our research team is particularly interested in B cells that reside in mucosal tissues and the antibodies they produce that end up at mucosal surfaces, interacting with both pathogens and microbiota. Specifically, we are focused on understanding immunoglobulin A (IgA) in all of its forms (monomers, dimers, and secretory) and are designing and testing therapeutic strategies that boost IgA antibodies at mucosal surfaces to inhibit virus replication and transmission, stabilize the microbiota, or all the above! Moms and babies: As a research team, we have a specific interest in the immune responses of moms and babies. We are working to understand better how maternal B cells and antibodies shape maternal and neonatal immune responses. Specifically, we are interested in the mucosal-mammary gland axis where plasma cells (mostly IgA) from mom’s mucosal tissues migrate to the mammary gland to secrete antibodies in milk. This evolutionary cross-talk allows antibacterial and antiviral antibodies that function in mom to contribute to protection and immune development in the suckling infant. Current projects in our lab involve designing immunization strategies that boost breast milk immunity against many viruses, including influenza viruses, rotaviruses, and norovirus. We are using single-cell technologies, animal models, and human clinical samples to accomplish this. Our lab is currently focused on four main areas Maternal immunization and lactogenic immunity Mechanisms of maternal antibody interference Mucosal immunization and airborne transmission of respiratory viruses Mucosal antibody immunobiology The Langel lab is focused on understanding antibody and B cell responses to viral infections, particularly during pregnancy and lactation. To accomplish this, the Langel lab is using single cell technologies, translational animal models, and human clinical samples. The Langel lab's overall goal is to improve maternal and neonatal health around the world. Stephanie Langel's Biography Research Information Research Interests Mucosal immune protection against infectious diseases, particularly in women and children. Research Projects Maternal immunization and lactogenic immunity Mechanisms of maternal antibody interference Mucosal immunization and airborne transmission of respiratory viruses Mucosal antibody immunobiology in the female reproductive tract Awards and Honors Seed fund awardee 2022 The Hypothesis Fund College of Food, Agricultural and Environmental Sciences Distinguished Alumni Award 2022 The Ohio State University Selected for Impact Talk 2021 Duke Center for AIDS Research (CFAR) Annual Research Retreat Student Registration Award 2021 American Society for Virology Annual Conference ‘Basic and Translational Research’ Top 5 abstract 2021 Duke Pediatrics Research Retreat Derfner Foundation Award 2020 Children’s Hospital Miracle Network, Duke Department of Pediatrics Travel scholarship 2020 ‘Antibodies as Drugs: from B cell biology to new treatments’ Keystone meeting, Santa Fe, NM Abstract selected for an oral presentation 2020 ‘Antibodies as Drugs: from B cell biology to new treatments’ Keystone meeting, Santa Fe, NM Postdoctoral poster presentation award 2019 Department of Molecular Genetics and Microbiology retreat, Duke University Travel Award 2018 American Society for Virology Annual Meeting Professional Memberships Society for Mucosal Immunology American Society for Virology American Association of Immunologists Publications https://pubmed.ncbi.nlm.nih.gov/?term=langel+sn&sort=date Education PhD Ohio State University Virology, Immunology 2018 Master of Science Virginia Polytechnic and State University (Virginia Tech) Immunology 2013 Bachelor of Science Ohio State University Animal Sciences, Life Sciences ( with Research Distinction) 2011 Additional Information Personal Statement I have studied mucosal antibody responses for 10 years, and have developed an interdisciplinary combination of knowledge, experience, and skill for assessing antibody function during different disease states. My graduate work in the laboratory of Dr. Linda Saif, member of the National Academy of Sciences, provided me with strong training in mucosal viral immunology. Specifically, I studied the mucosal immune response to a novel enteric coronavirus in pregnant and lactating swine. I discovered the role of intestinal IgA plasma cells that traffic to the mammary gland and secrete IgA into breast milk and protect neonates against coronavirus challenge. Additionally, I worked extensively with gnotobiotic piglets to study the role of probiotic bacteria in immunomodulation of the intestinal antibody response against rotavirus immunization and infection. My research during my postdoctoral training in Dr. Sallie Permar’s lab at the Duke Human Vaccine Institute further expanded my knowledge of the biology of IgA antibodies, the most dominant antibody at most mucosal surfaces. I engineered dimeric IgA monoclonal antibodies that could passively transfer into the breast milk of lactating mice and protect against rotavirus disease in suckling neonates. My background studying mucosal antibody responses led to a Bill and Melinda Gates Foundation grant (PI: S. Langel) to study mucosal immunization strategies to generate neutralizing antibodies at mucosal surfaces that protect against influenza or SARS-CoV-2. During this time, I transitioned to a Medical Instructor (non-tenure track faculty) position within the lab of Dr. Georgia Tomaras. Within the Tomaras lab, I was integrated into her influenza team (funded by the Duke Center for Influenza Vaccinate Innovation Center) where we optimized and validated antigen binding, hemagglutinin inhibition and microneutralization assays for the detection of anti-influenza antibodies. Throughout my graduate and postgraduate years, I have developed a strong background in virology, mucosal immunology, and infectious diseases. I have demonstrated an ability to optimize and validate assays for the functional characterization of antibodies against multiple pathogens. These experiences reflect the work my lab is currently doing to better understand B cell and antibody biology at mucosal surfaces. My background studying antibody function during multiple different disease states makes my lab uniquely capable to explore mucosal immunity to viral infections at the maternal/neonatal interface and in the female reproductive tract. Website Langel Research Team
Degree: Master of Science
Stephanie Langel, PhD Email [contact withheld] Phone [contact withheld] Office Location: Biomedical Research Building 2109 Adelbert Rd. Ofc. 424 Cleveland, Ohio 44106 Assistant Professor, Department of Pathology, School of Medicine Member, Center for Global Health and Diseases, School of Medicine Our dynamic research team is dedicated to understanding our immune responses at mucosal surfaces. Mucosal immune responses protect us against invading pathogens and environmental irritants but also tolerate and are shaped by our commensal microbiota - billions of bacteria, fungi, and viruses living within us. Our research team is particularly interested in B cells that reside in mucosal tissues and the antibodies they produce that end up at mucosal surfaces, interacting with both pathogens and microbiota. Specifically, we are focused on understanding immunoglobulin A (IgA) in all of its forms (monomers, dimers, and secretory) and are designing and testing therapeutic strategies that boost IgA antibodies at mucosal surfaces to inhibit virus replication and transmission, stabilize the microbiota, or all the above! Moms and babies: As a research team, we have a specific interest in the immune responses of moms and babies. We are working to understand better how maternal B cells and antibodies shape maternal and neonatal immune responses. Specifically, we are interested in the mucosal-mammary gland axis where plasma cells (mostly IgA) from mom’s mucosal tissues migrate to the mammary gland to secrete antibodies in milk. This evolutionary cross-talk allows antibacterial and antiviral antibodies that function in mom to contribute to protection and immune development in the suckling infant. Current projects in our lab involve designing immunization strategies that boost breast milk immunity against many viruses, including influenza viruses, rotaviruses, and norovirus. We are using single-cell technologies, animal models, and human clinical samples to accomplish this. Our lab is currently focused on four main areas Maternal immunization and lactogenic immunity Mechanisms of maternal antibody interference Mucosal immunization and airborne transmission of respiratory viruses Mucosal antibody immunobiology The Langel lab is focused on understanding antibody and B cell responses to viral infections, particularly during pregnancy and lactation. To accomplish this, the Langel lab is using single cell technologies, translational animal models, and human clinical samples. The Langel lab's overall goal is to improve maternal and neonatal health around the world. Stephanie Langel's Biography Research Information Research Interests Mucosal immune protection against infectious diseases, particularly in women and children. Research Projects Maternal immunization and lactogenic immunity Mechanisms of maternal antibody interference Mucosal immunization and airborne transmission of respiratory viruses Mucosal antibody immunobiology in the female reproductive tract Awards and Honors Seed fund awardee 2022 The Hypothesis Fund College of Food, Agricultural and Environmental Sciences Distinguished Alumni Award 2022 The Ohio State University Selected for Impact Talk 2021 Duke Center for AIDS Research (CFAR) Annual Research Retreat Student Registration Award 2021 American Society for Virology Annual Conference ‘Basic and Translational Research’ Top 5 abstract 2021 Duke Pediatrics Research Retreat Derfner Foundation Award 2020 Children’s Hospital Miracle Network, Duke Department of Pediatrics Travel scholarship 2020 ‘Antibodies as Drugs: from B cell biology to new treatments’ Keystone meeting, Santa Fe, NM Abstract selected for an oral presentation 2020 ‘Antibodies as Drugs: from B cell biology to new treatments’ Keystone meeting, Santa Fe, NM Postdoctoral poster presentation award 2019 Department of Molecular Genetics and Microbiology retreat, Duke University Travel Award 2018 American Society for Virology Annual Meeting Professional Memberships Society for Mucosal Immunology American Society for Virology American Association of Immunologists Publications https://pubmed.ncbi.nlm.nih.gov/?term=langel+sn&sort=date Education PhD Ohio State University Virology, Immunology 2018 Master of Science Virginia Polytechnic and State University (Virginia Tech) Immunology 2013 Bachelor of Science Ohio State University Animal Sciences, Life Sciences ( with Research Distinction) 2011 Additional Information Personal Statement I have studied mucosal antibody responses for 10 years, and have developed an interdisciplinary combination of knowledge, experience, and skill for assessing antibody function during different disease states. My graduate work in the laboratory of Dr. Linda Saif, member of the National Academy of Sciences, provided me with strong training in mucosal viral immunology. Specifically, I studied the mucosal immune response to a novel enteric coronavirus in pregnant and lactating swine. I discovered the role of intestinal IgA plasma cells that traffic to the mammary gland and secrete IgA into breast milk and protect neonates against coronavirus challenge. Additionally, I worked extensively with gnotobiotic piglets to study the role of probiotic bacteria in immunomodulation of the intestinal antibody response against rotavirus immunization and infection. My research during my postdoctoral training in Dr. Sallie Permar’s lab at the Duke Human Vaccine Institute further expanded my knowledge of the biology of IgA antibodies, the most dominant antibody at most mucosal surfaces. I engineered dimeric IgA monoclonal antibodies that could passively transfer into the breast milk of lactating mice and protect against rotavirus disease in suckling neonates. My background studying mucosal antibody responses led to a Bill and Melinda Gates Foundation grant (PI: S. Langel) to study mucosal immunization strategies to generate neutralizing antibodies at mucosal surfaces that protect against influenza or SARS-CoV-2. During this time, I transitioned to a Medical Instructor (non-tenure track faculty) position within the lab of Dr. Georgia Tomaras. Within the Tomaras lab, I was integrated into her influenza team (funded by the Duke Center for Influenza Vaccinate Innovation Center) where we optimized and validated antigen binding, hemagglutinin inhibition and microneutralization assays for the detection of anti-influenza antibodies. Throughout my graduate and postgraduate years, I have developed a strong background in virology, mucosal immunology, and infectious diseases. I have demonstrated an ability to optimize and validate assays for the functional characterization of antibodies against multiple pathogens. These experiences reflect the work my lab is currently doing to better understand B cell and antibody biology at mucosal surfaces. My background studying antibody function during multiple different disease states makes my lab uniquely capable to explore mucosal immunity to viral infections at the maternal/neonatal interface and in the female reproductive tract. Website Langel Research Team
Degree: PhD
Stephanie Langel, PhD Email [contact withheld] Phone [contact withheld] Office Location: Biomedical Research Building 2109 Adelbert Rd. Ofc. 424 Cleveland, Ohio 44106 Assistant Professor, Department of Pathology, School of Medicine Member, Center for Global Health and Diseases, School of Medicine
Degree: PhD
Stephanie Langel, PhD Email [contact withheld] Phone [contact withheld] Office Location: Biomedical Research Building 2109 Adelbert Rd. Ofc. 424 Cleveland, Ohio 44106 Assistant Professor, Department of Pathology, School of Medicine Member, Center for Global Health and Diseases, School of Medicine Our dynamic research team is dedicated to understanding our immune responses at mucosal surfaces. Mucosal immune responses protect us against invading pathogens and environmental irritants but also tolerate and are shaped by our commensal microbiota - billions of bacteria, fungi, and viruses living within us. Our research team is particularly interested in B cells that reside in mucosal tissues and the antibodies they produce that end up at mucosal surfaces, interacting with both pathogens and microbiota. Specifically, we are focused on understanding immunoglobulin A (IgA) in all of its forms (monomers, dimers, and secretory) and are designing and testing therapeutic strategies that boost IgA antibodies at mucosal surfaces to inhibit virus replication and transmission, stabilize the microbiota, or all the above! Moms and babies: As a research team, we have a specific interest in the immune responses of moms and babies. We are working to understand better how maternal B cells and antibodies shape maternal and neonatal immune responses. Specifically, we are interested in the mucosal-mammary gland axis where plasma cells (mostly IgA) from mom’s mucosal tissues migrate to the mammary gland to secrete antibodies in milk. This evolutionary cross-talk allows antibacterial and antiviral antibodies that function in mom to contribute to protection and immune development in the suckling infant. Current projects in our lab involve designing immunization strategies that boost breast milk immunity against many viruses, including influenza viruses, rotaviruses, and norovirus. We are using single-cell technologies, animal models, and human clinical samples to accomplish this. Our lab is currently focused on four main areas Maternal immunization and lactogenic immunity Mechanisms of maternal antibody interference Mucosal immunization and airborne transmission of respiratory viruses Mucosal antibody immunobiology The Langel lab is focused on understanding antibody and B cell responses to viral infections, particularly during pregnancy and lactation. To accomplish this, the Langel lab is using single cell technologies, translational animal models, and human clinical samples. The Langel lab's overall goal is to improve maternal and neonatal health around the world. Stephanie Langel's Biography Research Information Research Interests Mucosal immune protection against infectious diseases, particularly in women and children. Research Projects Maternal immunization and lactogenic immunity Mechanisms of maternal antibody interference Mucosal immunization and airborne transmission of respiratory viruses Mucosal antibody immunobiology in the female reproductive tract Awards and Honors Seed fund awardee 2022 The Hypothesis Fund College of Food, Agricultural and Environmental Sciences Distinguished Alumni Award 2022 The Ohio State University Selected for Impact Talk 2021 Duke Center for AIDS Research (CFAR) Annual Research Retreat Student Registration Award 2021 American Society for Virology Annual Conference ‘Basic and Translational Research’ Top 5 abstract 2021 Duke Pediatrics Research Retreat Derfner Foundation Award 2020 Children’s Hospital Miracle Network, Duke Department of Pediatrics Travel scholarship 2020 ‘Antibodies as Drugs: from B cell biology to new treatments’ Keystone meeting, Santa Fe, NM Abstract selected for an oral presentation 2020 ‘Antibodies as Drugs: from B cell biology to new treatments’ Keystone meeting, Santa Fe, NM Postdoctoral poster presentation award 2019 Department of Molecular Genetics and Microbiology retreat, Duke University Travel Award 2018 American Society for Virology Annual Meeting Professional Memberships Society for Mucosal Immunology American Society for Virology American Association of Immunologists Publications https://pubmed.ncbi.nlm.nih.gov/?term=langel+sn&sort=date Education PhD Ohio State University Virology, Immunology 2018 Master of Science Virginia Polytechnic and State University (Virginia Tech) Immunology 2013 Bachelor of Science Ohio State University Animal Sciences, Life Sciences ( with Research Distinction) 2011 Additional Information Personal Statement I have studied mucosal antibody responses for 10 years, and have developed an interdisciplinary combination of knowledge, experience, and skill for assessing antibody function during different disease states. My graduate work in the laboratory of Dr. Linda Saif, member of the National Academy of Sciences, provided me with strong training in mucosal viral immunology. Specifically, I studied the mucosal immune response to a novel enteric coronavirus in pregnant and lactating swine. I discovered the role of intestinal IgA plasma cells that traffic to the mammary gland and secrete IgA into breast milk and protect neonates against coronavirus challenge. Additionally, I worked extensively with gnotobiotic piglets to study the role of probiotic bacteria in immunomodulation of the intestinal antibody response against rotavirus immunization and infection. My research during my postdoctoral training in Dr. Sallie Permar’s lab at the Duke Human Vaccine Institute further expanded my knowledge of the biology of IgA antibodies, the most dominant antibody at most mucosal surfaces. I engineered dimeric IgA monoclonal antibodies that could passively transfer into the breast milk of lactating mice and protect against rotavirus disease in suckling neonates. My background studying mucosal antibody responses led to a Bill and Melinda Gates Foundation grant (PI: S. Langel) to study mucosal immunization strategies to generate neutralizing antibodies at mucosal surfaces that protect against influenza or SARS-CoV-2. During this time, I transitioned to a Medical Instructor (non-tenure track faculty) position within the lab of Dr. Georgia Tomaras. Within the Tomaras lab, I was integrated into her influenza team (funded by the Duke Center for Influenza Vaccinate Innovation Center) where we optimized and validated antigen binding, hemagglutinin inhibition and microneutralization assays for the detection of anti-influenza antibodies. Throughout my graduate and postgraduate years, I have developed a strong background in virology, mucosal immunology, and infectious diseases. I have demonstrated an ability to optimize and validate assays for the functional characterization of antibodies against multiple pathogens. These experiences reflect the work my lab is currently doing to better understand B cell and antibody biology at mucosal surfaces. My background studying antibody function during multiple different disease states makes my lab uniquely capable to explore mucosal immunity to viral infections at the maternal/neonatal interface and in the female reproductive tract. Website Langel Research Team
Education record: Ohio State University Animal Sciences, Life Sciences ( with Research Distinction) 2011
Stephanie Langel, PhD Email [contact withheld] Phone [contact withheld] Office Location: Biomedical Research Building 2109 Adelbert Rd. Ofc. 424 Cleveland, Ohio 44106 Assistant Professor, Department of Pathology, School of Medicine Member, Center for Global Health and Diseases, School of Medicine Our dynamic research team is dedicated to understanding our immune responses at mucosal surfaces. Mucosal immune responses protect us against invading pathogens and environmental irritants but also tolerate and are shaped by our commensal microbiota - billions of bacteria, fungi, and viruses living within us. Our research team is particularly interested in B cells that reside in mucosal tissues and the antibodies they produce that end up at mucosal surfaces, interacting with both pathogens and microbiota. Specifically, we are focused on understanding immunoglobulin A (IgA) in all of its forms (monomers, dimers, and secretory) and are designing and testing therapeutic strategies that boost IgA antibodies at mucosal surfaces to inhibit virus replication and transmission, stabilize the microbiota, or all the above! Moms and babies: As a research team, we have a specific interest in the immune responses of moms and babies. We are working to understand better how maternal B cells and antibodies shape maternal and neonatal immune responses. Specifically, we are interested in the mucosal-mammary gland axis where plasma cells (mostly IgA) from mom’s mucosal tissues migrate to the mammary gland to secrete antibodies in milk. This evolutionary cross-talk allows antibacterial and antiviral antibodies that function in mom to contribute to protection and immune development in the suckling infant. Current projects in our lab involve designing immunization strategies that boost breast milk immunity against many viruses, including influenza viruses, rotaviruses, and norovirus. We are using single-cell technologies, animal models, and human clinical samples to accomplish this. Our lab is currently focused on four main areas Maternal immunization and lactogenic immunity Mechanisms of maternal antibody interference Mucosal immunization and airborne transmission of respiratory viruses Mucosal antibody immunobiology The Langel lab is focused on understanding antibody and B cell responses to viral infections, particularly during pregnancy and lactation. To accomplish this, the Langel lab is using single cell technologies, translational animal models, and human clinical samples. The Langel lab's overall goal is to improve maternal and neonatal health around the world. Stephanie Langel's Biography Research Information Research Interests Mucosal immune protection against infectious diseases, particularly in women and children. Research Projects Maternal immunization and lactogenic immunity Mechanisms of maternal antibody interference Mucosal immunization and airborne transmission of respiratory viruses Mucosal antibody immunobiology in the female reproductive tract Awards and Honors Seed fund awardee 2022 The Hypothesis Fund College of Food, Agricultural and Environmental Sciences Distinguished Alumni Award 2022 The Ohio State University Selected for Impact Talk 2021 Duke Center for AIDS Research (CFAR) Annual Research Retreat Student Registration Award 2021 American Society for Virology Annual Conference ‘Basic and Translational Research’ Top 5 abstract 2021 Duke Pediatrics Research Retreat Derfner Foundation Award 2020 Children’s Hospital Miracle Network, Duke Department of Pediatrics Travel scholarship 2020 ‘Antibodies as Drugs: from B cell biology to new treatments’ Keystone meeting, Santa Fe, NM Abstract selected for an oral presentation 2020 ‘Antibodies as Drugs: from B cell biology to new treatments’ Keystone meeting, Santa Fe, NM Postdoctoral poster presentation award 2019 Department of Molecular Genetics and Microbiology retreat, Duke University Travel Award 2018 American Society for Virology Annual Meeting Professional Memberships Society for Mucosal Immunology American Society for Virology American Association of Immunologists Publications https://pubmed.ncbi.nlm.nih.gov/?term=langel+sn&sort=date Education PhD Ohio State University Virology, Immunology 2018 Master of Science Virginia Polytechnic and State University (Virginia Tech) Immunology 2013 Bachelor of Science Ohio State University Animal Sciences, Life Sciences ( with Research Distinction) 2011 Additional Information Personal Statement I have studied mucosal antibody responses for 10 years, and have developed an interdisciplinary combination of knowledge, experience, and skill for assessing antibody function during different disease states. My graduate work in the laboratory of Dr. Linda Saif, member of the National Academy of Sciences, provided me with strong training in mucosal viral immunology. Specifically, I studied the mucosal immune response to a novel enteric coronavirus in pregnant and lactating swine. I discovered the role of intestinal IgA plasma cells that traffic to the mammary gland and secrete IgA into breast milk and protect neonates against coronavirus challenge. Additionally, I worked extensively with gnotobiotic piglets to study the role of probiotic bacteria in immunomodulation of the intestinal antibody response against rotavirus immunization and infection. My research during my postdoctoral training in Dr. Sallie Permar’s lab at the Duke Human Vaccine Institute further expanded my knowledge of the biology of IgA antibodies, the most dominant antibody at most mucosal surfaces. I engineered dimeric IgA monoclonal antibodies that could passively transfer into the breast milk of lactating mice and protect against rotavirus disease in suckling neonates. My background studying mucosal antibody responses led to a Bill and Melinda Gates Foundation grant (PI: S. Langel) to study mucosal immunization strategies to generate neutralizing antibodies at mucosal surfaces that protect against influenza or SARS-CoV-2. During this time, I transitioned to a Medical Instructor (non-tenure track faculty) position within the lab of Dr. Georgia Tomaras. Within the Tomaras lab, I was integrated into her influenza team (funded by the Duke Center for Influenza Vaccinate Innovation Center) where we optimized and validated antigen binding, hemagglutinin inhibition and microneutralization assays for the detection of anti-influenza antibodies. Throughout my graduate and postgraduate years, I have developed a strong background in virology, mucosal immunology, and infectious diseases. I have demonstrated an ability to optimize and validate assays for the functional characterization of antibodies against multiple pathogens. These experiences reflect the work my lab is currently doing to better understand B cell and antibody biology at mucosal surfaces. My background studying antibody function during multiple different disease states makes my lab uniquely capable to explore mucosal immunity to viral infections at the maternal/neonatal interface and in the female reproductive tract. Website Langel Research Team
Education record: Ohio State University Virology, Immunology 2018
Stephanie Langel, PhD Email [contact withheld] Phone [contact withheld] Office Location: Biomedical Research Building 2109 Adelbert Rd. Ofc. 424 Cleveland, Ohio 44106 Assistant Professor, Department of Pathology, School of Medicine Member, Center for Global Health and Diseases, School of Medicine Our dynamic research team is dedicated to understanding our immune responses at mucosal surfaces. Mucosal immune responses protect us against invading pathogens and environmental irritants but also tolerate and are shaped by our commensal microbiota - billions of bacteria, fungi, and viruses living within us. Our research team is particularly interested in B cells that reside in mucosal tissues and the antibodies they produce that end up at mucosal surfaces, interacting with both pathogens and microbiota. Specifically, we are focused on understanding immunoglobulin A (IgA) in all of its forms (monomers, dimers, and secretory) and are designing and testing therapeutic strategies that boost IgA antibodies at mucosal surfaces to inhibit virus replication and transmission, stabilize the microbiota, or all the above! Moms and babies: As a research team, we have a specific interest in the immune responses of moms and babies. We are working to understand better how maternal B cells and antibodies shape maternal and neonatal immune responses. Specifically, we are interested in the mucosal-mammary gland axis where plasma cells (mostly IgA) from mom’s mucosal tissues migrate to the mammary gland to secrete antibodies in milk. This evolutionary cross-talk allows antibacterial and antiviral antibodies that function in mom to contribute to protection and immune development in the suckling infant. Current projects in our lab involve designing immunization strategies that boost breast milk immunity against many viruses, including influenza viruses, rotaviruses, and norovirus. We are using single-cell technologies, animal models, and human clinical samples to accomplish this. Our lab is currently focused on four main areas Maternal immunization and lactogenic immunity Mechanisms of maternal antibody interference Mucosal immunization and airborne transmission of respiratory viruses Mucosal antibody immunobiology The Langel lab is focused on understanding antibody and B cell responses to viral infections, particularly during pregnancy and lactation. To accomplish this, the Langel lab is using single cell technologies, translational animal models, and human clinical samples. The Langel lab's overall goal is to improve maternal and neonatal health around the world. Stephanie Langel's Biography Research Information Research Interests Mucosal immune protection against infectious diseases, particularly in women and children. Research Projects Maternal immunization and lactogenic immunity Mechanisms of maternal antibody interference Mucosal immunization and airborne transmission of respiratory viruses Mucosal antibody immunobiology in the female reproductive tract Awards and Honors Seed fund awardee 2022 The Hypothesis Fund College of Food, Agricultural and Environmental Sciences Distinguished Alumni Award 2022 The Ohio State University Selected for Impact Talk 2021 Duke Center for AIDS Research (CFAR) Annual Research Retreat Student Registration Award 2021 American Society for Virology Annual Conference ‘Basic and Translational Research’ Top 5 abstract 2021 Duke Pediatrics Research Retreat Derfner Foundation Award 2020 Children’s Hospital Miracle Network, Duke Department of Pediatrics Travel scholarship 2020 ‘Antibodies as Drugs: from B cell biology to new treatments’ Keystone meeting, Santa Fe, NM Abstract selected for an oral presentation 2020 ‘Antibodies as Drugs: from B cell biology to new treatments’ Keystone meeting, Santa Fe, NM Postdoctoral poster presentation award 2019 Department of Molecular Genetics and Microbiology retreat, Duke University Travel Award 2018 American Society for Virology Annual Meeting Professional Memberships Society for Mucosal Immunology American Society for Virology American Association of Immunologists Publications https://pubmed.ncbi.nlm.nih.gov/?term=langel+sn&sort=date Education PhD Ohio State University Virology, Immunology 2018 Master of Science Virginia Polytechnic and State University (Virginia Tech) Immunology 2013 Bachelor of Science Ohio State University Animal Sciences, Life Sciences ( with Research Distinction) 2011 Additional Information Personal Statement I have studied mucosal antibody responses for 10 years, and have developed an interdisciplinary combination of knowledge, experience, and skill for assessing antibody function during different disease states. My graduate work in the laboratory of Dr. Linda Saif, member of the National Academy of Sciences, provided me with strong training in mucosal viral immunology. Specifically, I studied the mucosal immune response to a novel enteric coronavirus in pregnant and lactating swine. I discovered the role of intestinal IgA plasma cells that traffic to the mammary gland and secrete IgA into breast milk and protect neonates against coronavirus challenge. Additionally, I worked extensively with gnotobiotic piglets to study the role of probiotic bacteria in immunomodulation of the intestinal antibody response against rotavirus immunization and infection. My research during my postdoctoral training in Dr. Sallie Permar’s lab at the Duke Human Vaccine Institute further expanded my knowledge of the biology of IgA antibodies, the most dominant antibody at most mucosal surfaces. I engineered dimeric IgA monoclonal antibodies that could passively transfer into the breast milk of lactating mice and protect against rotavirus disease in suckling neonates. My background studying mucosal antibody responses led to a Bill and Melinda Gates Foundation grant (PI: S. Langel) to study mucosal immunization strategies to generate neutralizing antibodies at mucosal surfaces that protect against influenza or SARS-CoV-2. During this time, I transitioned to a Medical Instructor (non-tenure track faculty) position within the lab of Dr. Georgia Tomaras. Within the Tomaras lab, I was integrated into her influenza team (funded by the Duke Center for Influenza Vaccinate Innovation Center) where we optimized and validated antigen binding, hemagglutinin inhibition and microneutralization assays for the detection of anti-influenza antibodies. Throughout my graduate and postgraduate years, I have developed a strong background in virology, mucosal immunology, and infectious diseases. I have demonstrated an ability to optimize and validate assays for the functional characterization of antibodies against multiple pathogens. These experiences reflect the work my lab is currently doing to better understand B cell and antibody biology at mucosal surfaces. My background studying antibody function during multiple different disease states makes my lab uniquely capable to explore mucosal immunity to viral infections at the maternal/neonatal interface and in the female reproductive tract. Website Langel Research Team
Education record: postdoctoral training
Stephanie Langel, PhD Email [contact withheld] Phone [contact withheld] Office Location: Biomedical Research Building 2109 Adelbert Rd. Ofc. 424 Cleveland, Ohio 44106 Assistant Professor, Department of Pathology, School of Medicine Member, Center for Global Health and Diseases, School of Medicine Our dynamic research team is dedicated to understanding our immune responses at mucosal surfaces. Mucosal immune responses protect us against invading pathogens and environmental irritants but also tolerate and are shaped by our commensal microbiota - billions of bacteria, fungi, and viruses living within us. Our research team is particularly interested in B cells that reside in mucosal tissues and the antibodies they produce that end up at mucosal surfaces, interacting with both pathogens and microbiota. Specifically, we are focused on understanding immunoglobulin A (IgA) in all of its forms (monomers, dimers, and secretory) and are designing and testing therapeutic strategies that boost IgA antibodies at mucosal surfaces to inhibit virus replication and transmission, stabilize the microbiota, or all the above! Moms and babies: As a research team, we have a specific interest in the immune responses of moms and babies. We are working to understand better how maternal B cells and antibodies shape maternal and neonatal immune responses. Specifically, we are interested in the mucosal-mammary gland axis where plasma cells (mostly IgA) from mom’s mucosal tissues migrate to the mammary gland to secrete antibodies in milk. This evolutionary cross-talk allows antibacterial and antiviral antibodies that function in mom to contribute to protection and immune development in the suckling infant. Current projects in our lab involve designing immunization strategies that boost breast milk immunity against many viruses, including influenza viruses, rotaviruses, and norovirus. We are using single-cell technologies, animal models, and human clinical samples to accomplish this. Our lab is currently focused on four main areas Maternal immunization and lactogenic immunity Mechanisms of maternal antibody interference Mucosal immunization and airborne transmission of respiratory viruses Mucosal antibody immunobiology The Langel lab is focused on understanding antibody and B cell responses to viral infections, particularly during pregnancy and lactation. To accomplish this, the Langel lab is using single cell technologies, translational animal models, and human clinical samples. The Langel lab's overall goal is to improve maternal and neonatal health around the world. Stephanie Langel's Biography Research Information Research Interests Mucosal immune protection against infectious diseases, particularly in women and children. Research Projects Maternal immunization and lactogenic immunity Mechanisms of maternal antibody interference Mucosal immunization and airborne transmission of respiratory viruses Mucosal antibody immunobiology in the female reproductive tract Awards and Honors Seed fund awardee 2022 The Hypothesis Fund College of Food, Agricultural and Environmental Sciences Distinguished Alumni Award 2022 The Ohio State University Selected for Impact Talk 2021 Duke Center for AIDS Research (CFAR) Annual Research Retreat Student Registration Award 2021 American Society for Virology Annual Conference ‘Basic and Translational Research’ Top 5 abstract 2021 Duke Pediatrics Research Retreat Derfner Foundation Award 2020 Children’s Hospital Miracle Network, Duke Department of Pediatrics Travel scholarship 2020 ‘Antibodies as Drugs: from B cell biology to new treatments’ Keystone meeting, Santa Fe, NM Abstract selected for an oral presentation 2020 ‘Antibodies as Drugs: from B cell biology to new treatments’ Keystone meeting, Santa Fe, NM Postdoctoral poster presentation award 2019 Department of Molecular Genetics and Microbiology retreat, Duke University Travel Award 2018 American Society for Virology Annual Meeting Professional Memberships Society for Mucosal Immunology American Society for Virology American Association of Immunologists Publications https://pubmed.ncbi.nlm.nih.gov/?term=langel+sn&sort=date Education PhD Ohio State University Virology, Immunology 2018 Master of Science Virginia Polytechnic and State University (Virginia Tech) Immunology 2013 Bachelor of Science Ohio State University Animal Sciences, Life Sciences ( with Research Distinction) 2011 Additional Information Personal Statement I have studied mucosal antibody responses for 10 years, and have developed an interdisciplinary combination of knowledge, experience, and skill for assessing antibody function during different disease states. My graduate work in the laboratory of Dr. Linda Saif, member of the National Academy of Sciences, provided me with strong training in mucosal viral immunology. Specifically, I studied the mucosal immune response to a novel enteric coronavirus in pregnant and lactating swine. I discovered the role of intestinal IgA plasma cells that traffic to the mammary gland and secrete IgA into breast milk and protect neonates against coronavirus challenge. Additionally, I worked extensively with gnotobiotic piglets to study the role of probiotic bacteria in immunomodulation of the intestinal antibody response against rotavirus immunization and infection. My research during my postdoctoral training in Dr. Sallie Permar’s lab at the Duke Human Vaccine Institute further expanded my knowledge of the biology of IgA antibodies, the most dominant antibody at most mucosal surfaces. I engineered dimeric IgA monoclonal antibodies that could passively transfer into the breast milk of lactating mice and protect against rotavirus disease in suckling neonates. My background studying mucosal antibody responses led to a Bill and Melinda Gates Foundation grant (PI: S. Langel) to study mucosal immunization strategies to generate neutralizing antibodies at mucosal surfaces that protect against influenza or SARS-CoV-2. During this time, I transitioned to a Medical Instructor (non-tenure track faculty) position within the lab of Dr. Georgia Tomaras. Within the Tomaras lab, I was integrated into her influenza team (funded by the Duke Center for Influenza Vaccinate Innovation Center) where we optimized and validated antigen binding, hemagglutinin inhibition and microneutralization assays for the detection of anti-influenza antibodies. Throughout my graduate and postgraduate years, I have developed a strong background in virology, mucosal immunology, and infectious diseases. I have demonstrated an ability to optimize and validate assays for the functional characterization of antibodies against multiple pathogens. These experiences reflect the work my lab is currently doing to better understand B cell and antibody biology at mucosal surfaces. My background studying antibody function during multiple different disease states makes my lab uniquely capable to explore mucosal immunity to viral infections at the maternal/neonatal interface and in the female reproductive tract. Website Langel Research Team
Education record: Virginia Polytechnic and State University (Virginia Tech) Immunology 2013
Stephanie Langel, PhD Email [contact withheld] Phone [contact withheld] Office Location: Biomedical Research Building 2109 Adelbert Rd. Ofc. 424 Cleveland, Ohio 44106 Assistant Professor, Department of Pathology, School of Medicine Member, Center for Global Health and Diseases, School of Medicine Our dynamic research team is dedicated to understanding our immune responses at mucosal surfaces. Mucosal immune responses protect us against invading pathogens and environmental irritants but also tolerate and are shaped by our commensal microbiota - billions of bacteria, fungi, and viruses living within us. Our research team is particularly interested in B cells that reside in mucosal tissues and the antibodies they produce that end up at mucosal surfaces, interacting with both pathogens and microbiota. Specifically, we are focused on understanding immunoglobulin A (IgA) in all of its forms (monomers, dimers, and secretory) and are designing and testing therapeutic strategies that boost IgA antibodies at mucosal surfaces to inhibit virus replication and transmission, stabilize the microbiota, or all the above! Moms and babies: As a research team, we have a specific interest in the immune responses of moms and babies. We are working to understand better how maternal B cells and antibodies shape maternal and neonatal immune responses. Specifically, we are interested in the mucosal-mammary gland axis where plasma cells (mostly IgA) from mom’s mucosal tissues migrate to the mammary gland to secrete antibodies in milk. This evolutionary cross-talk allows antibacterial and antiviral antibodies that function in mom to contribute to protection and immune development in the suckling infant. Current projects in our lab involve designing immunization strategies that boost breast milk immunity against many viruses, including influenza viruses, rotaviruses, and norovirus. We are using single-cell technologies, animal models, and human clinical samples to accomplish this. Our lab is currently focused on four main areas Maternal immunization and lactogenic immunity Mechanisms of maternal antibody interference Mucosal immunization and airborne transmission of respiratory viruses Mucosal antibody immunobiology The Langel lab is focused on understanding antibody and B cell responses to viral infections, particularly during pregnancy and lactation. To accomplish this, the Langel lab is using single cell technologies, translational animal models, and human clinical samples. The Langel lab's overall goal is to improve maternal and neonatal health around the world. Stephanie Langel's Biography Research Information Research Interests Mucosal immune protection against infectious diseases, particularly in women and children. Research Projects Maternal immunization and lactogenic immunity Mechanisms of maternal antibody interference Mucosal immunization and airborne transmission of respiratory viruses Mucosal antibody immunobiology in the female reproductive tract Awards and Honors Seed fund awardee 2022 The Hypothesis Fund College of Food, Agricultural and Environmental Sciences Distinguished Alumni Award 2022 The Ohio State University Selected for Impact Talk 2021 Duke Center for AIDS Research (CFAR) Annual Research Retreat Student Registration Award 2021 American Society for Virology Annual Conference ‘Basic and Translational Research’ Top 5 abstract 2021 Duke Pediatrics Research Retreat Derfner Foundation Award 2020 Children’s Hospital Miracle Network, Duke Department of Pediatrics Travel scholarship 2020 ‘Antibodies as Drugs: from B cell biology to new treatments’ Keystone meeting, Santa Fe, NM Abstract selected for an oral presentation 2020 ‘Antibodies as Drugs: from B cell biology to new treatments’ Keystone meeting, Santa Fe, NM Postdoctoral poster presentation award 2019 Department of Molecular Genetics and Microbiology retreat, Duke University Travel Award 2018 American Society for Virology Annual Meeting Professional Memberships Society for Mucosal Immunology American Society for Virology American Association of Immunologists Publications https://pubmed.ncbi.nlm.nih.gov/?term=langel+sn&sort=date Education PhD Ohio State University Virology, Immunology 2018 Master of Science Virginia Polytechnic and State University (Virginia Tech) Immunology 2013 Bachelor of Science Ohio State University Animal Sciences, Life Sciences ( with Research Distinction) 2011 Additional Information Personal Statement I have studied mucosal antibody responses for 10 years, and have developed an interdisciplinary combination of knowledge, experience, and skill for assessing antibody function during different disease states. My graduate work in the laboratory of Dr. Linda Saif, member of the National Academy of Sciences, provided me with strong training in mucosal viral immunology. Specifically, I studied the mucosal immune response to a novel enteric coronavirus in pregnant and lactating swine. I discovered the role of intestinal IgA plasma cells that traffic to the mammary gland and secrete IgA into breast milk and protect neonates against coronavirus challenge. Additionally, I worked extensively with gnotobiotic piglets to study the role of probiotic bacteria in immunomodulation of the intestinal antibody response against rotavirus immunization and infection. My research during my postdoctoral training in Dr. Sallie Permar’s lab at the Duke Human Vaccine Institute further expanded my knowledge of the biology of IgA antibodies, the most dominant antibody at most mucosal surfaces. I engineered dimeric IgA monoclonal antibodies that could passively transfer into the breast milk of lactating mice and protect against rotavirus disease in suckling neonates. My background studying mucosal antibody responses led to a Bill and Melinda Gates Foundation grant (PI: S. Langel) to study mucosal immunization strategies to generate neutralizing antibodies at mucosal surfaces that protect against influenza or SARS-CoV-2. During this time, I transitioned to a Medical Instructor (non-tenure track faculty) position within the lab of Dr. Georgia Tomaras. Within the Tomaras lab, I was integrated into her influenza team (funded by the Duke Center for Influenza Vaccinate Innovation Center) where we optimized and validated antigen binding, hemagglutinin inhibition and microneutralization assays for the detection of anti-influenza antibodies. Throughout my graduate and postgraduate years, I have developed a strong background in virology, mucosal immunology, and infectious diseases. I have demonstrated an ability to optimize and validate assays for the functional characterization of antibodies against multiple pathogens. These experiences reflect the work my lab is currently doing to better understand B cell and antibody biology at mucosal surfaces. My background studying antibody function during multiple different disease states makes my lab uniquely capable to explore mucosal immunity to viral infections at the maternal/neonatal interface and in the female reproductive tract. Website Langel Research Team
Identity: Stephanie Langel
Stephanie Langel, PhD Email [contact withheld] Phone [contact withheld] Office Location: Biomedical Research Building 2109 Adelbert Rd. Ofc. 424 Cleveland, Ohio 44106 Assistant Professor, Department of Pathology, School of Medicine Member, Center for Global Health and Diseases, School of Medicine
Professional role: Assistant Professor, Department of Pathology, School of Medicine
Stephanie Langel, PhD Email [contact withheld] Phone [contact withheld] Office Location: Biomedical Research Building 2109 Adelbert Rd. Ofc. 424 Cleveland, Ohio 44106 Assistant Professor, Department of Pathology, School of Medicine Member, Center for Global Health and Diseases, School of Medicine
Professional role: Member, Center for Global Health and Diseases, School of Medicine
Stephanie Langel, PhD Email [contact withheld] Phone [contact withheld] Office Location: Biomedical Research Building 2109 Adelbert Rd. Ofc. 424 Cleveland, Ohio 44106 Assistant Professor, Department of Pathology, School of Medicine Member, Center for Global Health and Diseases, School of Medicine
Professional role: My research during my postdoctoral training in Dr. Sallie Permar’s lab at the Duke Human Vaccine Institute further expanded my knowledge of the biology of IgA antibodies, the most dominant antibody at most mucosal surfaces. I engineered dimeric IgA monoclonal antibodies that could passively transfer into the breast milk of lactating mice and protect against rotavirus disease in suckling neonates. My background studying mucosal antibody responses led to a Bill and Melinda Gates Foundation grant (PI: S. Langel) to study mucosal immunization strategies to generate neutralizing antibodies at mucosal surfaces that protect against influenza or SARS-CoV-2. During this time, I transitioned to a Medical Instructor (non-tenure track faculty) position within the lab of Dr. Georgia Tomaras. Within the Tomaras lab, I was integrated into her influenza team (funded by the Duke Center for Influenza Vaccinate Innovation Center) where we optimized and validated antigen binding, hemagglutinin inhibition and microneutralization assays for the detection of anti-influenza antibodies.
Stephanie Langel, PhD Email [contact withheld] Phone [contact withheld] Office Location: Biomedical Research Building 2109 Adelbert Rd. Ofc. 424 Cleveland, Ohio 44106 Assistant Professor, Department of Pathology, School of Medicine Member, Center for Global Health and Diseases, School of Medicine Our dynamic research team is dedicated to understanding our immune responses at mucosal surfaces. Mucosal immune responses protect us against invading pathogens and environmental irritants but also tolerate and are shaped by our commensal microbiota - billions of bacteria, fungi, and viruses living within us. Our research team is particularly interested in B cells that reside in mucosal tissues and the antibodies they produce that end up at mucosal surfaces, interacting with both pathogens and microbiota. Specifically, we are focused on understanding immunoglobulin A (IgA) in all of its forms (monomers, dimers, and secretory) and are designing and testing therapeutic strategies that boost IgA antibodies at mucosal surfaces to inhibit virus replication and transmission, stabilize the microbiota, or all the above! Moms and babies: As a research team, we have a specific interest in the immune responses of moms and babies. We are working to understand better how maternal B cells and antibodies shape maternal and neonatal immune responses. Specifically, we are interested in the mucosal-mammary gland axis where plasma cells (mostly IgA) from mom’s mucosal tissues migrate to the mammary gland to secrete antibodies in milk. This evolutionary cross-talk allows antibacterial and antiviral antibodies that function in mom to contribute to protection and immune development in the suckling infant. Current projects in our lab involve designing immunization strategies that boost breast milk immunity against many viruses, including influenza viruses, rotaviruses, and norovirus. We are using single-cell technologies, animal models, and human clinical samples to accomplish this. Our lab is currently focused on four main areas Maternal immunization and lactogenic immunity Mechanisms of maternal antibody interference Mucosal immunization and airborne transmission of respiratory viruses Mucosal antibody immunobiology The Langel lab is focused on understanding antibody and B cell responses to viral infections, particularly during pregnancy and lactation. To accomplish this, the Langel lab is using single cell technologies, translational animal models, and human clinical samples. The Langel lab's overall goal is to improve maternal and neonatal health around the world. Stephanie Langel's Biography Research Information Research Interests Mucosal immune protection against infectious diseases, particularly in women and children. Research Projects Maternal immunization and lactogenic immunity Mechanisms of maternal antibody interference Mucosal immunization and airborne transmission of respiratory viruses Mucosal antibody immunobiology in the female reproductive tract Awards and Honors Seed fund awardee 2022 The Hypothesis Fund College of Food, Agricultural and Environmental Sciences Distinguished Alumni Award 2022 The Ohio State University Selected for Impact Talk 2021 Duke Center for AIDS Research (CFAR) Annual Research Retreat Student Registration Award 2021 American Society for Virology Annual Conference ‘Basic and Translational Research’ Top 5 abstract 2021 Duke Pediatrics Research Retreat Derfner Foundation Award 2020 Children’s Hospital Miracle Network, Duke Department of Pediatrics Travel scholarship 2020 ‘Antibodies as Drugs: from B cell biology to new treatments’ Keystone meeting, Santa Fe, NM Abstract selected for an oral presentation 2020 ‘Antibodies as Drugs: from B cell biology to new treatments’ Keystone meeting, Santa Fe, NM Postdoctoral poster presentation award 2019 Department of Molecular Genetics and Microbiology retreat, Duke University Travel Award 2018 American Society for Virology Annual Meeting Professional Memberships Society for Mucosal Immunology American Society for Virology American Association of Immunologists Publications https://pubmed.ncbi.nlm.nih.gov/?term=langel+sn&sort=date Education PhD Ohio State University Virology, Immunology 2018 Master of Science Virginia Polytechnic and State University (Virginia Tech) Immunology 2013 Bachelor of Science Ohio State University Animal Sciences, Life Sciences ( with Research Distinction) 2011 Additional Information Personal Statement I have studied mucosal antibody responses for 10 years, and have developed an interdisciplinary combination of knowledge, experience, and skill for assessing antibody function during different disease states. My graduate work in the laboratory of Dr. Linda Saif, member of the National Academy of Sciences, provided me with strong training in mucosal viral immunology. Specifically, I studied the mucosal immune response to a novel enteric coronavirus in pregnant and lactating swine. I discovered the role of intestinal IgA plasma cells that traffic to the mammary gland and secrete IgA into breast milk and protect neonates against coronavirus challenge. Additionally, I worked extensively with gnotobiotic piglets to study the role of probiotic bacteria in immunomodulation of the intestinal antibody response against rotavirus immunization and infection. My research during my postdoctoral training in Dr. Sallie Permar’s lab at the Duke Human Vaccine Institute further expanded my knowledge of the biology of IgA antibodies, the most dominant antibody at most mucosal surfaces. I engineered dimeric IgA monoclonal antibodies that could passively transfer into the breast milk of lactating mice and protect against rotavirus disease in suckling neonates. My background studying mucosal antibody responses led to a Bill and Melinda Gates Foundation grant (PI: S. Langel) to study mucosal immunization strategies to generate neutralizing antibodies at mucosal surfaces that protect against influenza or SARS-CoV-2. During this time, I transitioned to a Medical Instructor (non-tenure track faculty) position within the lab of Dr. Georgia Tomaras. Within the Tomaras lab, I was integrated into her influenza team (funded by the Duke Center for Influenza Vaccinate Innovation Center) where we optimized and validated antigen binding, hemagglutinin inhibition and microneutralization assays for the detection of anti-influenza antibodies. Throughout my graduate and postgraduate years, I have developed a strong background in virology, mucosal immunology, and infectious diseases. I have demonstrated an ability to optimize and validate assays for the functional characterization of antibodies against multiple pathogens. These experiences reflect the work my lab is currently doing to better understand B cell and antibody biology at mucosal surfaces. My background studying antibody function during multiple different disease states makes my lab uniquely capable to explore mucosal immunity to viral infections at the maternal/neonatal interface and in the female reproductive tract. Website Langel Research Team
Official profile: Official profile
Stephanie Langel, PhD Email [contact withheld] Phone [contact withheld] Office Location: Biomedical Research Building 2109 Adelbert Rd. Ofc. 424 Cleveland, Ohio 44106 Assistant Professor, Department of Pathology, School of Medicine Member, Center for Global Health and Diseases, School of Medicine
Stephanie Langel, PhD Email [contact withheld] Phone [contact withheld] Office Location: Biomedical Research Building 2109 Adelbert Rd. Ofc. 424 Cleveland, Ohio 44106 Assistant Professor, Department of Pathology, School of Medicine Member, Center for Global Health and Diseases, School of Medicine Our dynamic research team is dedicated to understanding our immune responses at mucosal surfaces. Mucosal immune responses protect us against invading pathogens and environmental irritants but also tolerate and are shaped by our commensal microbiota - billions of bacteria, fungi, and viruses living within us. Our research team is particularly interested in B cells that reside in mucosal tissues and the antibodies they produce that end up at mucosal surfaces, interacting with both pathogens and microbiota. Specifically, we are focused on understanding immunoglobulin A (IgA) in all of its forms (monomers, dimers, and secretory) and are designing and testing therapeutic strategies that boost IgA antibodies at mucosal surfaces to inhibit virus replication and transmission, stabilize the microbiota, or all the above! Moms and babies: As a research team, we have a specific interest in the immune responses of moms and babies. We are working to understand better how maternal B cells and antibodies shape maternal and neonatal immune responses. Specifically, we are interested in the mucosal-mammary gland axis where plasma cells (mostly IgA) from mom’s mucosal tissues migrate to the mammary gland to secrete antibodies in milk. This evolutionary cross-talk allows antibacterial and antiviral antibodies that function in mom to contribute to protection and immune development in the suckling infant. Current projects in our lab involve designing immunization strategies that boost breast milk immunity against many viruses, including influenza viruses, rotaviruses, and norovirus. We are using single-cell technologies, animal models, and human clinical samples to accomplish this. Our lab is currently focused on four main areas Maternal immunization and lactogenic immunity Mechanisms of maternal antibody interference Mucosal immunization and airborne transmission of respiratory viruses Mucosal antibody immunobiology The Langel lab is focused on understanding antibody and B cell responses to viral infections, particularly during pregnancy and lactation. To accomplish this, the Langel lab is using single cell technologies, translational animal models, and human clinical samples. The Langel lab's overall goal is to improve maternal and neonatal health around the world. Stephanie Langel's Biography Research Information Research Interests Mucosal immune protection against infectious diseases, particularly in women and children. Research Projects Maternal immunization and lactogenic immunity Mechanisms of maternal antibody interference Mucosal immunization and airborne transmission of respiratory viruses Mucosal antibody immunobiology in the female reproductive tract Awards and Honors Seed fund awardee 2022 The Hypothesis Fund College of Food, Agricultural and Environmental Sciences Distinguished Alumni Award 2022 The Ohio State University Selected for Impact Talk 2021 Duke Center for AIDS Research (CFAR) Annual Research Retreat Student Registration Award 2021 American Society for Virology Annual Conference ‘Basic and Translational Research’ Top 5 abstract 2021 Duke Pediatrics Research Retreat Derfner Foundation Award 2020 Children’s Hospital Miracle Network, Duke Department of Pediatrics Travel scholarship 2020 ‘Antibodies as Drugs: from B cell biology to new treatments’ Keystone meeting, Santa Fe, NM Abstract selected for an oral presentation 2020 ‘Antibodies as Drugs: from B cell biology to new treatments’ Keystone meeting, Santa Fe, NM Postdoctoral poster presentation award 2019 Department of Molecular Genetics and Microbiology retreat, Duke University Travel Award 2018 American Society for Virology Annual Meeting Professional Memberships Society for Mucosal Immunology American Society for Virology American Association of Immunologists Publications https://pubmed.ncbi.nlm.nih.gov/?term=langel+sn&sort=date Education PhD Ohio State University Virology, Immunology 2018 Master of Science Virginia Polytechnic and State University (Virginia Tech) Immunology 2013 Bachelor of Science Ohio State University Animal Sciences, Life Sciences ( with Research Distinction) 2011 Additional Information Personal Statement I have studied mucosal antibody responses for 10 years, and have developed an interdisciplinary combination of knowledge, experience, and skill for assessing antibody function during different disease states. My graduate work in the laboratory of Dr. Linda Saif, member of the National Academy of Sciences, provided me with strong training in mucosal viral immunology. Specifically, I studied the mucosal immune response to a novel enteric coronavirus in pregnant and lactating swine. I discovered the role of intestinal IgA plasma cells that traffic to the mammary gland and secrete IgA into breast milk and protect neonates against coronavirus challenge. Additionally, I worked extensively with gnotobiotic piglets to study the role of probiotic bacteria in immunomodulation of the intestinal antibody response against rotavirus immunization and infection. My research during my postdoctoral training in Dr. Sallie Permar’s lab at the Duke Human Vaccine Institute further expanded my knowledge of the biology of IgA antibodies, the most dominant antibody at most mucosal surfaces. I engineered dimeric IgA monoclonal antibodies that could passively transfer into the breast milk of lactating mice and protect against rotavirus disease in suckling neonates. My background studying mucosal antibody responses led to a Bill and Melinda Gates Foundation grant (PI: S. Langel) to study mucosal immunization strategies to generate neutralizing antibodies at mucosal surfaces that protect against influenza or SARS-CoV-2. During this time, I transitioned to a Medical Instructor (non-tenure track faculty) position within the lab of Dr. Georgia Tomaras. Within the Tomaras lab, I was integrated into her influenza team (funded by the Duke Center for Influenza Vaccinate Innovation Center) where we optimized and validated antigen binding, hemagglutinin inhibition and microneutralization assays for the detection of anti-influenza antibodies. Throughout my graduate and postgraduate years, I have developed a strong background in virology, mucosal immunology, and infectious diseases. I have demonstrated an ability to optimize and validate assays for the functional characterization of antibodies against multiple pathogens. These experiences reflect the work my lab is currently doing to better understand B cell and antibody biology at mucosal surfaces. My background studying antibody function during multiple different disease states makes my lab uniquely capable to explore mucosal immunity to viral infections at the maternal/neonatal interface and in the female reproductive tract. Website Langel Research Team
Research interests: Mucosal antibody immunobiology in the female reproductive tract
Stephanie Langel, PhD Email [contact withheld] Phone [contact withheld] Office Location: Biomedical Research Building 2109 Adelbert Rd. Ofc. 424 Cleveland, Ohio 44106 Assistant Professor, Department of Pathology, School of Medicine Member, Center for Global Health and Diseases, School of Medicine Our dynamic research team is dedicated to understanding our immune responses at mucosal surfaces. Mucosal immune responses protect us against invading pathogens and environmental irritants but also tolerate and are shaped by our commensal microbiota - billions of bacteria, fungi, and viruses living within us. Our research team is particularly interested in B cells that reside in mucosal tissues and the antibodies they produce that end up at mucosal surfaces, interacting with both pathogens and microbiota. Specifically, we are focused on understanding immunoglobulin A (IgA) in all of its forms (monomers, dimers, and secretory) and are designing and testing therapeutic strategies that boost IgA antibodies at mucosal surfaces to inhibit virus replication and transmission, stabilize the microbiota, or all the above! Moms and babies: As a research team, we have a specific interest in the immune responses of moms and babies. We are working to understand better how maternal B cells and antibodies shape maternal and neonatal immune responses. Specifically, we are interested in the mucosal-mammary gland axis where plasma cells (mostly IgA) from mom’s mucosal tissues migrate to the mammary gland to secrete antibodies in milk. This evolutionary cross-talk allows antibacterial and antiviral antibodies that function in mom to contribute to protection and immune development in the suckling infant. Current projects in our lab involve designing immunization strategies that boost breast milk immunity against many viruses, including influenza viruses, rotaviruses, and norovirus. We are using single-cell technologies, animal models, and human clinical samples to accomplish this. Our lab is currently focused on four main areas Maternal immunization and lactogenic immunity Mechanisms of maternal antibody interference Mucosal immunization and airborne transmission of respiratory viruses Mucosal antibody immunobiology The Langel lab is focused on understanding antibody and B cell responses to viral infections, particularly during pregnancy and lactation. To accomplish this, the Langel lab is using single cell technologies, translational animal models, and human clinical samples. The Langel lab's overall goal is to improve maternal and neonatal health around the world. Stephanie Langel's Biography Research Information Research Interests Mucosal immune protection against infectious diseases, particularly in women and children. Research Projects Maternal immunization and lactogenic immunity Mechanisms of maternal antibody interference Mucosal immunization and airborne transmission of respiratory viruses Mucosal antibody immunobiology in the female reproductive tract Awards and Honors Seed fund awardee 2022 The Hypothesis Fund College of Food, Agricultural and Environmental Sciences Distinguished Alumni Award 2022 The Ohio State University Selected for Impact Talk 2021 Duke Center for AIDS Research (CFAR) Annual Research Retreat Student Registration Award 2021 American Society for Virology Annual Conference ‘Basic and Translational Research’ Top 5 abstract 2021 Duke Pediatrics Research Retreat Derfner Foundation Award 2020 Children’s Hospital Miracle Network, Duke Department of Pediatrics Travel scholarship 2020 ‘Antibodies as Drugs: from B cell biology to new treatments’ Keystone meeting, Santa Fe, NM Abstract selected for an oral presentation 2020 ‘Antibodies as Drugs: from B cell biology to new treatments’ Keystone meeting, Santa Fe, NM Postdoctoral poster presentation award 2019 Department of Molecular Genetics and Microbiology retreat, Duke University Travel Award 2018 American Society for Virology Annual Meeting Professional Memberships Society for Mucosal Immunology American Society for Virology American Association of Immunologists Publications https://pubmed.ncbi.nlm.nih.gov/?term=langel+sn&sort=date Education PhD Ohio State University Virology, Immunology 2018 Master of Science Virginia Polytechnic and State University (Virginia Tech) Immunology 2013 Bachelor of Science Ohio State University Animal Sciences, Life Sciences ( with Research Distinction) 2011 Additional Information Personal Statement I have studied mucosal antibody responses for 10 years, and have developed an interdisciplinary combination of knowledge, experience, and skill for assessing antibody function during different disease states. My graduate work in the laboratory of Dr. Linda Saif, member of the National Academy of Sciences, provided me with strong training in mucosal viral immunology. Specifically, I studied the mucosal immune response to a novel enteric coronavirus in pregnant and lactating swine. I discovered the role of intestinal IgA plasma cells that traffic to the mammary gland and secrete IgA into breast milk and protect neonates against coronavirus challenge. Additionally, I worked extensively with gnotobiotic piglets to study the role of probiotic bacteria in immunomodulation of the intestinal antibody response against rotavirus immunization and infection. My research during my postdoctoral training in Dr. Sallie Permar’s lab at the Duke Human Vaccine Institute further expanded my knowledge of the biology of IgA antibodies, the most dominant antibody at most mucosal surfaces. I engineered dimeric IgA monoclonal antibodies that could passively transfer into the breast milk of lactating mice and protect against rotavirus disease in suckling neonates. My background studying mucosal antibody responses led to a Bill and Melinda Gates Foundation grant (PI: S. Langel) to study mucosal immunization strategies to generate neutralizing antibodies at mucosal surfaces that protect against influenza or SARS-CoV-2. During this time, I transitioned to a Medical Instructor (non-tenure track faculty) position within the lab of Dr. Georgia Tomaras. Within the Tomaras lab, I was integrated into her influenza team (funded by the Duke Center for Influenza Vaccinate Innovation Center) where we optimized and validated antigen binding, hemagglutinin inhibition and microneutralization assays for the detection of anti-influenza antibodies. Throughout my graduate and postgraduate years, I have developed a strong background in virology, mucosal immunology, and infectious diseases. I have demonstrated an ability to optimize and validate assays for the functional characterization of antibodies against multiple pathogens. These experiences reflect the work my lab is currently doing to better understand B cell and antibody biology at mucosal surfaces. My background studying antibody function during multiple different disease states makes my lab uniquely capable to explore mucosal immunity to viral infections at the maternal/neonatal interface and in the female reproductive tract. Website Langel Research Team
Research interests: Mucosal immune protection against infectious diseases, particularly in women and children.
Stephanie Langel, PhD Email [contact withheld] Phone [contact withheld] Office Location: Biomedical Research Building 2109 Adelbert Rd. Ofc. 424 Cleveland, Ohio 44106 Assistant Professor, Department of Pathology, School of Medicine Member, Center for Global Health and Diseases, School of Medicine Our dynamic research team is dedicated to understanding our immune responses at mucosal surfaces. Mucosal immune responses protect us against invading pathogens and environmental irritants but also tolerate and are shaped by our commensal microbiota - billions of bacteria, fungi, and viruses living within us. Our research team is particularly interested in B cells that reside in mucosal tissues and the antibodies they produce that end up at mucosal surfaces, interacting with both pathogens and microbiota. Specifically, we are focused on understanding immunoglobulin A (IgA) in all of its forms (monomers, dimers, and secretory) and are designing and testing therapeutic strategies that boost IgA antibodies at mucosal surfaces to inhibit virus replication and transmission, stabilize the microbiota, or all the above! Moms and babies: As a research team, we have a specific interest in the immune responses of moms and babies. We are working to understand better how maternal B cells and antibodies shape maternal and neonatal immune responses. Specifically, we are interested in the mucosal-mammary gland axis where plasma cells (mostly IgA) from mom’s mucosal tissues migrate to the mammary gland to secrete antibodies in milk. This evolutionary cross-talk allows antibacterial and antiviral antibodies that function in mom to contribute to protection and immune development in the suckling infant. Current projects in our lab involve designing immunization strategies that boost breast milk immunity against many viruses, including influenza viruses, rotaviruses, and norovirus. We are using single-cell technologies, animal models, and human clinical samples to accomplish this. Our lab is currently focused on four main areas Maternal immunization and lactogenic immunity Mechanisms of maternal antibody interference Mucosal immunization and airborne transmission of respiratory viruses Mucosal antibody immunobiology The Langel lab is focused on understanding antibody and B cell responses to viral infections, particularly during pregnancy and lactation. To accomplish this, the Langel lab is using single cell technologies, translational animal models, and human clinical samples. The Langel lab's overall goal is to improve maternal and neonatal health around the world. Stephanie Langel's Biography Research Information Research Interests Mucosal immune protection against infectious diseases, particularly in women and children. Research Projects Maternal immunization and lactogenic immunity Mechanisms of maternal antibody interference Mucosal immunization and airborne transmission of respiratory viruses Mucosal antibody immunobiology in the female reproductive tract Awards and Honors Seed fund awardee 2022 The Hypothesis Fund College of Food, Agricultural and Environmental Sciences Distinguished Alumni Award 2022 The Ohio State University Selected for Impact Talk 2021 Duke Center for AIDS Research (CFAR) Annual Research Retreat Student Registration Award 2021 American Society for Virology Annual Conference ‘Basic and Translational Research’ Top 5 abstract 2021 Duke Pediatrics Research Retreat Derfner Foundation Award 2020 Children’s Hospital Miracle Network, Duke Department of Pediatrics Travel scholarship 2020 ‘Antibodies as Drugs: from B cell biology to new treatments’ Keystone meeting, Santa Fe, NM Abstract selected for an oral presentation 2020 ‘Antibodies as Drugs: from B cell biology to new treatments’ Keystone meeting, Santa Fe, NM Postdoctoral poster presentation award 2019 Department of Molecular Genetics and Microbiology retreat, Duke University Travel Award 2018 American Society for Virology Annual Meeting Professional Memberships Society for Mucosal Immunology American Society for Virology American Association of Immunologists Publications https://pubmed.ncbi.nlm.nih.gov/?term=langel+sn&sort=date Education PhD Ohio State University Virology, Immunology 2018 Master of Science Virginia Polytechnic and State University (Virginia Tech) Immunology 2013 Bachelor of Science Ohio State University Animal Sciences, Life Sciences ( with Research Distinction) 2011 Additional Information Personal Statement I have studied mucosal antibody responses for 10 years, and have developed an interdisciplinary combination of knowledge, experience, and skill for assessing antibody function during different disease states. My graduate work in the laboratory of Dr. Linda Saif, member of the National Academy of Sciences, provided me with strong training in mucosal viral immunology. Specifically, I studied the mucosal immune response to a novel enteric coronavirus in pregnant and lactating swine. I discovered the role of intestinal IgA plasma cells that traffic to the mammary gland and secrete IgA into breast milk and protect neonates against coronavirus challenge. Additionally, I worked extensively with gnotobiotic piglets to study the role of probiotic bacteria in immunomodulation of the intestinal antibody response against rotavirus immunization and infection. My research during my postdoctoral training in Dr. Sallie Permar’s lab at the Duke Human Vaccine Institute further expanded my knowledge of the biology of IgA antibodies, the most dominant antibody at most mucosal surfaces. I engineered dimeric IgA monoclonal antibodies that could passively transfer into the breast milk of lactating mice and protect against rotavirus disease in suckling neonates. My background studying mucosal antibody responses led to a Bill and Melinda Gates Foundation grant (PI: S. Langel) to study mucosal immunization strategies to generate neutralizing antibodies at mucosal surfaces that protect against influenza or SARS-CoV-2. During this time, I transitioned to a Medical Instructor (non-tenure track faculty) position within the lab of Dr. Georgia Tomaras. Within the Tomaras lab, I was integrated into her influenza team (funded by the Duke Center for Influenza Vaccinate Innovation Center) where we optimized and validated antigen binding, hemagglutinin inhibition and microneutralization assays for the detection of anti-influenza antibodies. Throughout my graduate and postgraduate years, I have developed a strong background in virology, mucosal immunology, and infectious diseases. I have demonstrated an ability to optimize and validate assays for the functional characterization of antibodies against multiple pathogens. These experiences reflect the work my lab is currently doing to better understand B cell and antibody biology at mucosal surfaces. My background studying antibody function during multiple different disease states makes my lab uniquely capable to explore mucosal immunity to viral infections at the maternal/neonatal interface and in the female reproductive tract. Website Langel Research Team
Research interests: Our research team is particularly interested in B cells that reside in mucosal tissues and the antibodies they produce that end up at mucosal surfaces, interacting with both pathogens and microbiota.
Stephanie Langel, PhD Email [contact withheld] Phone [contact withheld] Office Location: Biomedical Research Building 2109 Adelbert Rd. Ofc. 424 Cleveland, Ohio 44106 Assistant Professor, Department of Pathology, School of Medicine Member, Center for Global Health and Diseases, School of Medicine Our dynamic research team is dedicated to understanding our immune responses at mucosal surfaces. Mucosal immune responses protect us against invading pathogens and environmental irritants but also tolerate and are shaped by our commensal microbiota - billions of bacteria, fungi, and viruses living within us. Our research team is particularly interested in B cells that reside in mucosal tissues and the antibodies they produce that end up at mucosal surfaces, interacting with both pathogens and microbiota. Specifically, we are focused on understanding immunoglobulin A (IgA) in all of its forms (monomers, dimers, and secretory) and are designing and testing therapeutic strategies that boost IgA antibodies at mucosal surfaces to inhibit virus replication and transmission, stabilize the microbiota, or all the above! Moms and babies: As a research team, we have a specific interest in the immune responses of moms and babies. We are working to understand better how maternal B cells and antibodies shape maternal and neonatal immune responses. Specifically, we are interested in the mucosal-mammary gland axis where plasma cells (mostly IgA) from mom’s mucosal tissues migrate to the mammary gland to secrete antibodies in milk. This evolutionary cross-talk allows antibacterial and antiviral antibodies that function in mom to contribute to protection and immune development in the suckling infant. Current projects in our lab involve designing immunization strategies that boost breast milk immunity against many viruses, including influenza viruses, rotaviruses, and norovirus. We are using single-cell technologies, animal models, and human clinical samples to accomplish this. Our lab is currently focused on four main areas Maternal immunization and lactogenic immunity Mechanisms of maternal antibody interference Mucosal immunization and airborne transmission of respiratory viruses Mucosal antibody immunobiology The Langel lab is focused on understanding antibody and B cell responses to viral infections, particularly during pregnancy and lactation. To accomplish this, the Langel lab is using single cell technologies, translational animal models, and human clinical samples. The Langel lab's overall goal is to improve maternal and neonatal health around the world. Stephanie Langel's Biography Research Information Research Interests Mucosal immune protection against infectious diseases, particularly in women and children. Research Projects Maternal immunization and lactogenic immunity Mechanisms of maternal antibody interference Mucosal immunization and airborne transmission of respiratory viruses Mucosal antibody immunobiology in the female reproductive tract Awards and Honors Seed fund awardee 2022 The Hypothesis Fund College of Food, Agricultural and Environmental Sciences Distinguished Alumni Award 2022 The Ohio State University Selected for Impact Talk 2021 Duke Center for AIDS Research (CFAR) Annual Research Retreat Student Registration Award 2021 American Society for Virology Annual Conference ‘Basic and Translational Research’ Top 5 abstract 2021 Duke Pediatrics Research Retreat Derfner Foundation Award 2020 Children’s Hospital Miracle Network, Duke Department of Pediatrics Travel scholarship 2020 ‘Antibodies as Drugs: from B cell biology to new treatments’ Keystone meeting, Santa Fe, NM Abstract selected for an oral presentation 2020 ‘Antibodies as Drugs: from B cell biology to new treatments’ Keystone meeting, Santa Fe, NM Postdoctoral poster presentation award 2019 Department of Molecular Genetics and Microbiology retreat, Duke University Travel Award 2018 American Society for Virology Annual Meeting Professional Memberships Society for Mucosal Immunology American Society for Virology American Association of Immunologists Publications https://pubmed.ncbi.nlm.nih.gov/?term=langel+sn&sort=date Education PhD Ohio State University Virology, Immunology 2018 Master of Science Virginia Polytechnic and State University (Virginia Tech) Immunology 2013 Bachelor of Science Ohio State University Animal Sciences, Life Sciences ( with Research Distinction) 2011 Additional Information Personal Statement I have studied mucosal antibody responses for 10 years, and have developed an interdisciplinary combination of knowledge, experience, and skill for assessing antibody function during different disease states. My graduate work in the laboratory of Dr. Linda Saif, member of the National Academy of Sciences, provided me with strong training in mucosal viral immunology. Specifically, I studied the mucosal immune response to a novel enteric coronavirus in pregnant and lactating swine. I discovered the role of intestinal IgA plasma cells that traffic to the mammary gland and secrete IgA into breast milk and protect neonates against coronavirus challenge. Additionally, I worked extensively with gnotobiotic piglets to study the role of probiotic bacteria in immunomodulation of the intestinal antibody response against rotavirus immunization and infection. My research during my postdoctoral training in Dr. Sallie Permar’s lab at the Duke Human Vaccine Institute further expanded my knowledge of the biology of IgA antibodies, the most dominant antibody at most mucosal surfaces. I engineered dimeric IgA monoclonal antibodies that could passively transfer into the breast milk of lactating mice and protect against rotavirus disease in suckling neonates. My background studying mucosal antibody responses led to a Bill and Melinda Gates Foundation grant (PI: S. Langel) to study mucosal immunization strategies to generate neutralizing antibodies at mucosal surfaces that protect against influenza or SARS-CoV-2. During this time, I transitioned to a Medical Instructor (non-tenure track faculty) position within the lab of Dr. Georgia Tomaras. Within the Tomaras lab, I was integrated into her influenza team (funded by the Duke Center for Influenza Vaccinate Innovation Center) where we optimized and validated antigen binding, hemagglutinin inhibition and microneutralization assays for the detection of anti-influenza antibodies. Throughout my graduate and postgraduate years, I have developed a strong background in virology, mucosal immunology, and infectious diseases. I have demonstrated an ability to optimize and validate assays for the functional characterization of antibodies against multiple pathogens. These experiences reflect the work my lab is currently doing to better understand B cell and antibody biology at mucosal surfaces. My background studying antibody function during multiple different disease states makes my lab uniquely capable to explore mucosal immunity to viral infections at the maternal/neonatal interface and in the female reproductive tract. Website Langel Research Team
Research interests: Specifically, we are focused on understanding immunoglobulin A (IgA) in all of its forms (monomers, dimers, and secretory) and are designing and testing therapeutic strategies that boost IgA antibodies at mucosal surfaces to inhibit virus replication and transmission, stabilize the microbiota, or all the above!
Stephanie Langel, PhD Email [contact withheld] Phone [contact withheld] Office Location: Biomedical Research Building 2109 Adelbert Rd. Ofc. 424 Cleveland, Ohio 44106 Assistant Professor, Department of Pathology, School of Medicine Member, Center for Global Health and Diseases, School of Medicine Our dynamic research team is dedicated to understanding our immune responses at mucosal surfaces. Mucosal immune responses protect us against invading pathogens and environmental irritants but also tolerate and are shaped by our commensal microbiota - billions of bacteria, fungi, and viruses living within us. Our research team is particularly interested in B cells that reside in mucosal tissues and the antibodies they produce that end up at mucosal surfaces, interacting with both pathogens and microbiota. Specifically, we are focused on understanding immunoglobulin A (IgA) in all of its forms (monomers, dimers, and secretory) and are designing and testing therapeutic strategies that boost IgA antibodies at mucosal surfaces to inhibit virus replication and transmission, stabilize the microbiota, or all the above! Moms and babies: As a research team, we have a specific interest in the immune responses of moms and babies. We are working to understand better how maternal B cells and antibodies shape maternal and neonatal immune responses. Specifically, we are interested in the mucosal-mammary gland axis where plasma cells (mostly IgA) from mom’s mucosal tissues migrate to the mammary gland to secrete antibodies in milk. This evolutionary cross-talk allows antibacterial and antiviral antibodies that function in mom to contribute to protection and immune development in the suckling infant. Current projects in our lab involve designing immunization strategies that boost breast milk immunity against many viruses, including influenza viruses, rotaviruses, and norovirus. We are using single-cell technologies, animal models, and human clinical samples to accomplish this. Our lab is currently focused on four main areas Maternal immunization and lactogenic immunity Mechanisms of maternal antibody interference Mucosal immunization and airborne transmission of respiratory viruses Mucosal antibody immunobiology The Langel lab is focused on understanding antibody and B cell responses to viral infections, particularly during pregnancy and lactation. To accomplish this, the Langel lab is using single cell technologies, translational animal models, and human clinical samples. The Langel lab's overall goal is to improve maternal and neonatal health around the world. Stephanie Langel's Biography Research Information Research Interests Mucosal immune protection against infectious diseases, particularly in women and children. Research Projects Maternal immunization and lactogenic immunity Mechanisms of maternal antibody interference Mucosal immunization and airborne transmission of respiratory viruses Mucosal antibody immunobiology in the female reproductive tract Awards and Honors Seed fund awardee 2022 The Hypothesis Fund College of Food, Agricultural and Environmental Sciences Distinguished Alumni Award 2022 The Ohio State University Selected for Impact Talk 2021 Duke Center for AIDS Research (CFAR) Annual Research Retreat Student Registration Award 2021 American Society for Virology Annual Conference ‘Basic and Translational Research’ Top 5 abstract 2021 Duke Pediatrics Research Retreat Derfner Foundation Award 2020 Children’s Hospital Miracle Network, Duke Department of Pediatrics Travel scholarship 2020 ‘Antibodies as Drugs: from B cell biology to new treatments’ Keystone meeting, Santa Fe, NM Abstract selected for an oral presentation 2020 ‘Antibodies as Drugs: from B cell biology to new treatments’ Keystone meeting, Santa Fe, NM Postdoctoral poster presentation award 2019 Department of Molecular Genetics and Microbiology retreat, Duke University Travel Award 2018 American Society for Virology Annual Meeting Professional Memberships Society for Mucosal Immunology American Society for Virology American Association of Immunologists Publications https://pubmed.ncbi.nlm.nih.gov/?term=langel+sn&sort=date Education PhD Ohio State University Virology, Immunology 2018 Master of Science Virginia Polytechnic and State University (Virginia Tech) Immunology 2013 Bachelor of Science Ohio State University Animal Sciences, Life Sciences ( with Research Distinction) 2011 Additional Information Personal Statement I have studied mucosal antibody responses for 10 years, and have developed an interdisciplinary combination of knowledge, experience, and skill for assessing antibody function during different disease states. My graduate work in the laboratory of Dr. Linda Saif, member of the National Academy of Sciences, provided me with strong training in mucosal viral immunology. Specifically, I studied the mucosal immune response to a novel enteric coronavirus in pregnant and lactating swine. I discovered the role of intestinal IgA plasma cells that traffic to the mammary gland and secrete IgA into breast milk and protect neonates against coronavirus challenge. Additionally, I worked extensively with gnotobiotic piglets to study the role of probiotic bacteria in immunomodulation of the intestinal antibody response against rotavirus immunization and infection. My research during my postdoctoral training in Dr. Sallie Permar’s lab at the Duke Human Vaccine Institute further expanded my knowledge of the biology of IgA antibodies, the most dominant antibody at most mucosal surfaces. I engineered dimeric IgA monoclonal antibodies that could passively transfer into the breast milk of lactating mice and protect against rotavirus disease in suckling neonates. My background studying mucosal antibody responses led to a Bill and Melinda Gates Foundation grant (PI: S. Langel) to study mucosal immunization strategies to generate neutralizing antibodies at mucosal surfaces that protect against influenza or SARS-CoV-2. During this time, I transitioned to a Medical Instructor (non-tenure track faculty) position within the lab of Dr. Georgia Tomaras. Within the Tomaras lab, I was integrated into her influenza team (funded by the Duke Center for Influenza Vaccinate Innovation Center) where we optimized and validated antigen binding, hemagglutinin inhibition and microneutralization assays for the detection of anti-influenza antibodies. Throughout my graduate and postgraduate years, I have developed a strong background in virology, mucosal immunology, and infectious diseases. I have demonstrated an ability to optimize and validate assays for the functional characterization of antibodies against multiple pathogens. These experiences reflect the work my lab is currently doing to better understand B cell and antibody biology at mucosal surfaces. My background studying antibody function during multiple different disease states makes my lab uniquely capable to explore mucosal immunity to viral infections at the maternal/neonatal interface and in the female reproductive tract. Website Langel Research Team