Cardiovascular Diseases Fellowship at Duke University School of Medicine
As of 2016 · Last known relationship
Conducted research training in Robert Lefkowitz's laboratory during cardiology fellowship
James William Wisler is a Duke cardiologist whose work connects cardiovascular medicine with research on non-canonical signaling, biased GPCR signaling, and aortic aneurysm biology. He is listed as an Assistant Professor of Medicine at Duke University and has Cardiology as a clinical interest. He earned an M.D. from The Ohio State University College of Medicine in 2009, completed Duke internal medicine residency from 2009 to 2011 and cardiovascular diseases fellowship from 2011 to 2016, and pursued the ABIM research track during fellowship. His publications address β-arrestin signaling, carvedilol, biased agonism, anticoagulation, and cardiovascular education. His funded projects included studies of Mas receptor activation and molecular mechanisms of aortic aneurysm development.
Publication: “Antithrombotic therapy: new areas to understand efficacy and bleeding” (2014)
Publication: “beta-arrestin2 Is Necessary for Development of MPLW515L Mutant Primary Myelofibrosis” (2015)
Publication: “Biased G Protein-Coupled Receptor Signaling: Changing the Paradigm of Drug Discovery” (2018)
Publication: “Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor” (2016)
Publication: “Disrupting Fellow Education Through Group Texting: WhatsApp in Fellow Education?” (2018)
Publication: “Recent developments in biased agonism” (2014)
Publication: “The role of β-arrestin2-dependent signaling in thoracic aortic aneurysm formation in a murine model of Marfan syndrome” (2015)
Publication: “The β-arrestin-biased β-adrenergic receptor blocker carvedilol enhances skeletal muscle contractility” (2020)
Publication: “β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility” (2018)
Publication: “β-Arrestin2 mediates progression of murine primary myelofibrosis” (2017)
Each topic is linked to its supporting source in Sources.
Training includes Cardiovascular Diseases Fellowship at Duke University School of Medicine, Internal Medicine Residency at Duke University School of Medicine, M.D. from The Ohio State University College of Medicine, and Pursued training through the ABIM research track pathway during cardiology fellowship at Duke University, plus 4 more records.
Explore education and training2021
2017
As of 2016
As of 2011
As of 2009
Mechanistic studies of Mas receptor activation and its role in aortic aneurysm formation[8]
2017 to 2021
Molecular mechanisms of aortic aneurysm development[8]
2016 to 2017
Physiologic and pharmacologic consequences of non-canonical, non-G-protein-mediated signaling[7]