Co-Leader, Immune Oncology Program, Case Comprehensive Cancer Center[1]
David Wald
About
In 2008, Dr. Wald joined Case Western Reserve University's Department of Pathology.
postdoctoral research in the laboratories of Drs. Bryan Roth and William Tse
Research interests
identification and development of novel therapeutic strategies for cancer with a particular focus on Acute myeloid leukemia (AML) · My area of investigation includes cellular therapies for cancer, cancer drug development, and genetic and molecular analyses of leukemia.
Training
Reviewed sources document Education record: Case Western Reserve University, Education record: Clinical Pathology at University Hospitals Cleveland Medical Center, Education record: David Wald graduated from Cornell University in 1997., and Education record: Doctor of Medicine Case Western Reserve University Pathology 2005, plus 4 more training records.
Explore education and trainingResearch
Reviewed sources document identification and development of novel therapeutic strategies for cancer with a particular focus on Acute myeloid leukemia (AML) and My area of investigation includes cellular therapies for cancer, cancer drug development, and genetic and molecular analyses of leukemia.. Publication attribution is still being resolved.
Explore researchEducation and career
Reviewed Sep 9, 2026Physician, Department of Pathology, Clinical[1]
Professor, Department of Pathology, School of Medicine[1]
Other education records
Case Western Reserve University[1]
Clinical Pathology at University Hospitals Cleveland Medical Center[1]
David Wald graduated from Cornell University in 1997.[1]
Doctor of Medicine Case Western Reserve University Pathology 2005[1]
graduate student[1]
MSTP Student[1]
postdoctoral research[1]
ultimately attaining a Ph.D. in Pathology[1]
Research
identification and development of novel therapeutic strategies for cancer with a particular focus on Acute myeloid leukemia (AML)[1]
My area of investigation includes cellular therapies for cancer, cancer drug development, and genetic and molecular analyses of leukemia.[1]
Publications
0 attributed works. Counts reflect resolved authorship and may be incomplete.
No publications resolved yet.
Sources
Sources are listed once and connected to each accepted claim they support. Excerpts preserve the source language used in the review.
- [1]David Wald | Pathology | School of Medicine | Case Western Reserve University
20 source claims · Reviewed Sep 9, 2026
Biographical context: In 2008, Dr. Wald joined Case Western Reserve University's Department of Pathology.
David Wald, MD, PhD Email [contact withheld] Phone [contact withheld] Fax Number [contact withheld] Professor, Department of Pathology, School of Medicine Co-Leader, Immune Oncology Program, Case Comprehensive Cancer Center David Wald graduated from Cornell University in 1997. He then matriculated to Case Western Reserve University as an MSTP Student. While a graduate student, he studied Toll-like receptor signaling ultimately attaining a Ph.D. in Pathology. After the completion of his medical school requirements, Dr. Wald continued his clinical training in Clinical Pathology at University Hospitals Cleveland Medical Center. Dr. Wald also conducted postdoctoral research in the laboratories of Drs. Bryan Roth and William Tse. While in these laboratories, Dr. Wald developed an interest in cancer drug development and began to identify novel drug candidates for Acute Myeloid Leukemia and to explore their mechanisms of action. In 2008, Dr. Wald joined Case Western Reserve University's Department of Pathology. My area of investigation includes cellular therapies for cancer, cancer drug development, and genetic and molecular analyses of leukemia. David Wald's Biography Research Information Research Projects Our research efforts are centered around the identification and development of novel therapeutic strategies for cancer with a particular focus on Acute myeloid leukemia (AML). AML is one of the most common forms of leukemia in adults and despite advances in treatment the median survival in patients over the age of 56 is less than one year. One of the major problems is that elderly patients frequently are not able to tolerate the current therapeutics which have high toxicities leaving them with no satisfactory options. Our laboratory is involved in elucidating novel therapeutic approaches to more specifically target AML cells to try to improve the efficacy and lessen the toxicities of AML therapy. In particular, we are actively investigating three approaches that involve ATP depletion-mediated differentiation, the design of novel nucleoside analogues that exhibit leukemic cell preferential uptake, and the targeting of a particular kinase that appears to be dysregulated in AML. We are currently conducting studies to both define the mechanisms of these strategies as well as to further assess their clinical potential using both in vitro and mouse in vivo based approaches. External Appointments Title Physician, Department of Pathology, Clinical Organization/Publication University Hospitals Publications View All Publications Xiao, H., Gulen, M. F., Qin, J., Yao, J., Bulek, K., Kish, D., Altuntas, C. Z., Wald, D., Ma, C., Zhou, H., Tuohy, V. K., Fairchild, R. L., de la Motte, C., Cua, D., Vallance, B. A., Li, X. "The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis.." Immunity. 2007 Apr;26(4):461-75. Epub 2007 Mar 29. Gregory, T. K., Wald, D., Chen, Y., Vermaat, J. M., Xiong, Y., Tse, W. "Molecular prognostic markers for adult acute myeloid leukemia with normal cytogenetics.." J Hematol Oncol. 2009 Jun 2;2:23. doi: 10.1186/[contact withheld]. Education Doctor of Medicine Case Western Reserve University Pathology 2005 Bachelor of Science Cornell University 1997 Residencies, Internships and Fellowships Clinical Pathology University Hospitals Case Medical Center Additional Information View External Profile
Biographical context: postdoctoral research in the laboratories of Drs. Bryan Roth and William Tse
David Wald, MD, PhD Email [contact withheld] Phone [contact withheld] Fax Number [contact withheld] Professor, Department of Pathology, School of Medicine Co-Leader, Immune Oncology Program, Case Comprehensive Cancer Center David Wald graduated from Cornell University in 1997. He then matriculated to Case Western Reserve University as an MSTP Student. While a graduate student, he studied Toll-like receptor signaling ultimately attaining a Ph.D. in Pathology. After the completion of his medical school requirements, Dr. Wald continued his clinical training in Clinical Pathology at University Hospitals Cleveland Medical Center. Dr. Wald also conducted postdoctoral research in the laboratories of Drs. Bryan Roth and William Tse. While in these laboratories, Dr. Wald developed an interest in cancer drug development and began to identify novel drug candidates for Acute Myeloid Leukemia and to explore their mechanisms of action. In 2008, Dr. Wald joined Case Western Reserve University's Department of Pathology. My area of investigation includes cellular therapies for cancer, cancer drug development, and genetic and molecular analyses of leukemia. David Wald's Biography Research Information Research Projects Our research efforts are centered around the identification and development of novel therapeutic strategies for cancer with a particular focus on Acute myeloid leukemia (AML). AML is one of the most common forms of leukemia in adults and despite advances in treatment the median survival in patients over the age of 56 is less than one year. One of the major problems is that elderly patients frequently are not able to tolerate the current therapeutics which have high toxicities leaving them with no satisfactory options. Our laboratory is involved in elucidating novel therapeutic approaches to more specifically target AML cells to try to improve the efficacy and lessen the toxicities of AML therapy. In particular, we are actively investigating three approaches that involve ATP depletion-mediated differentiation, the design of novel nucleoside analogues that exhibit leukemic cell preferential uptake, and the targeting of a particular kinase that appears to be dysregulated in AML. We are currently conducting studies to both define the mechanisms of these strategies as well as to further assess their clinical potential using both in vitro and mouse in vivo based approaches. External Appointments Title Physician, Department of Pathology, Clinical Organization/Publication University Hospitals Publications View All Publications Xiao, H., Gulen, M. F., Qin, J., Yao, J., Bulek, K., Kish, D., Altuntas, C. Z., Wald, D., Ma, C., Zhou, H., Tuohy, V. K., Fairchild, R. L., de la Motte, C., Cua, D., Vallance, B. A., Li, X. "The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis.." Immunity. 2007 Apr;26(4):461-75. Epub 2007 Mar 29. Gregory, T. K., Wald, D., Chen, Y., Vermaat, J. M., Xiong, Y., Tse, W. "Molecular prognostic markers for adult acute myeloid leukemia with normal cytogenetics.." J Hematol Oncol. 2009 Jun 2;2:23. doi: 10.1186/[contact withheld]. Education Doctor of Medicine Case Western Reserve University Pathology 2005 Bachelor of Science Cornell University 1997 Residencies, Internships and Fellowships Clinical Pathology University Hospitals Case Medical Center Additional Information View External Profile
Degree: Bachelor of Science
David Wald, MD, PhD Email [contact withheld] Phone [contact withheld] Fax Number [contact withheld] Professor, Department of Pathology, School of Medicine Co-Leader, Immune Oncology Program, Case Comprehensive Cancer Center David Wald graduated from Cornell University in 1997. He then matriculated to Case Western Reserve University as an MSTP Student. While a graduate student, he studied Toll-like receptor signaling ultimately attaining a Ph.D. in Pathology. After the completion of his medical school requirements, Dr. Wald continued his clinical training in Clinical Pathology at University Hospitals Cleveland Medical Center. Dr. Wald also conducted postdoctoral research in the laboratories of Drs. Bryan Roth and William Tse. While in these laboratories, Dr. Wald developed an interest in cancer drug development and began to identify novel drug candidates for Acute Myeloid Leukemia and to explore their mechanisms of action. In 2008, Dr. Wald joined Case Western Reserve University's Department of Pathology. My area of investigation includes cellular therapies for cancer, cancer drug development, and genetic and molecular analyses of leukemia. David Wald's Biography Research Information Research Projects Our research efforts are centered around the identification and development of novel therapeutic strategies for cancer with a particular focus on Acute myeloid leukemia (AML). AML is one of the most common forms of leukemia in adults and despite advances in treatment the median survival in patients over the age of 56 is less than one year. One of the major problems is that elderly patients frequently are not able to tolerate the current therapeutics which have high toxicities leaving them with no satisfactory options. Our laboratory is involved in elucidating novel therapeutic approaches to more specifically target AML cells to try to improve the efficacy and lessen the toxicities of AML therapy. In particular, we are actively investigating three approaches that involve ATP depletion-mediated differentiation, the design of novel nucleoside analogues that exhibit leukemic cell preferential uptake, and the targeting of a particular kinase that appears to be dysregulated in AML. We are currently conducting studies to both define the mechanisms of these strategies as well as to further assess their clinical potential using both in vitro and mouse in vivo based approaches. External Appointments Title Physician, Department of Pathology, Clinical Organization/Publication University Hospitals Publications View All Publications Xiao, H., Gulen, M. F., Qin, J., Yao, J., Bulek, K., Kish, D., Altuntas, C. Z., Wald, D., Ma, C., Zhou, H., Tuohy, V. K., Fairchild, R. L., de la Motte, C., Cua, D., Vallance, B. A., Li, X. "The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis.." Immunity. 2007 Apr;26(4):461-75. Epub 2007 Mar 29. Gregory, T. K., Wald, D., Chen, Y., Vermaat, J. M., Xiong, Y., Tse, W. "Molecular prognostic markers for adult acute myeloid leukemia with normal cytogenetics.." J Hematol Oncol. 2009 Jun 2;2:23. doi: 10.1186/[contact withheld]. Education Doctor of Medicine Case Western Reserve University Pathology 2005 Bachelor of Science Cornell University 1997 Residencies, Internships and Fellowships Clinical Pathology University Hospitals Case Medical Center Additional Information View External Profile
Degree: MD
David Wald, MD, PhD Email [contact withheld] Phone [contact withheld] Fax Number [contact withheld] Professor, Department of Pathology, School of Medicine Co-Leader, Immune Oncology Program, Case Comprehensive Cancer Center David Wald graduated from Cornell University in 1997. He then matriculated to Case Western Reserve University as an MSTP Student. While a graduate student, he studied Toll-like receptor signaling ultimately attaining a Ph.D. in Pathology. After the completion of his medical school requirements, Dr. Wald continued his clinical training in Clinical Pathology at University Hospitals Cleveland Medical Center. Dr. Wald also conducted postdoctoral research in the laboratories of Drs. Bryan Roth and William Tse. While in these laboratories, Dr. Wald developed an interest in cancer drug development and began to identify novel drug candidates for Acute Myeloid Leukemia and to explore their mechanisms of action. In 2008, Dr. Wald joined Case Western Reserve University's Department of Pathology. My area of investigation includes cellular therapies for cancer, cancer drug development, and genetic and molecular analyses of leukemia. David Wald's Biography Research Information Research Projects Our research efforts are centered around the identification and development of novel therapeutic strategies for cancer with a particular focus on Acute myeloid leukemia (AML). AML is one of the most common forms of leukemia in adults and despite advances in treatment the median survival in patients over the age of 56 is less than one year. One of the major problems is that elderly patients frequently are not able to tolerate the current therapeutics which have high toxicities leaving them with no satisfactory options. Our laboratory is involved in elucidating novel therapeutic approaches to more specifically target AML cells to try to improve the efficacy and lessen the toxicities of AML therapy. In particular, we are actively investigating three approaches that involve ATP depletion-mediated differentiation, the design of novel nucleoside analogues that exhibit leukemic cell preferential uptake, and the targeting of a particular kinase that appears to be dysregulated in AML. We are currently conducting studies to both define the mechanisms of these strategies as well as to further assess their clinical potential using both in vitro and mouse in vivo based approaches. External Appointments Title Physician, Department of Pathology, Clinical Organization/Publication University Hospitals Publications View All Publications Xiao, H., Gulen, M. F., Qin, J., Yao, J., Bulek, K., Kish, D., Altuntas, C. Z., Wald, D., Ma, C., Zhou, H., Tuohy, V. K., Fairchild, R. L., de la Motte, C., Cua, D., Vallance, B. A., Li, X. "The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis.." Immunity. 2007 Apr;26(4):461-75. Epub 2007 Mar 29. Gregory, T. K., Wald, D., Chen, Y., Vermaat, J. M., Xiong, Y., Tse, W. "Molecular prognostic markers for adult acute myeloid leukemia with normal cytogenetics.." J Hematol Oncol. 2009 Jun 2;2:23. doi: 10.1186/[contact withheld]. Education Doctor of Medicine Case Western Reserve University Pathology 2005 Bachelor of Science Cornell University 1997 Residencies, Internships and Fellowships Clinical Pathology University Hospitals Case Medical Center Additional Information View External Profile
Degree: PhD
David Wald, MD, PhD Email [contact withheld] Phone [contact withheld] Fax Number [contact withheld] Professor, Department of Pathology, School of Medicine Co-Leader, Immune Oncology Program, Case Comprehensive Cancer Center David Wald graduated from Cornell University in 1997. He then matriculated to Case Western Reserve University as an MSTP Student. While a graduate student, he studied Toll-like receptor signaling ultimately attaining a Ph.D. in Pathology. After the completion of his medical school requirements, Dr. Wald continued his clinical training in Clinical Pathology at University Hospitals Cleveland Medical Center. Dr. Wald also conducted postdoctoral research in the laboratories of Drs. Bryan Roth and William Tse. While in these laboratories, Dr. Wald developed an interest in cancer drug development and began to identify novel drug candidates for Acute Myeloid Leukemia and to explore their mechanisms of action. In 2008, Dr. Wald joined Case Western Reserve University's Department of Pathology. My area of investigation includes cellular therapies for cancer, cancer drug development, and genetic and molecular analyses of leukemia. David Wald's Biography Research Information Research Projects Our research efforts are centered around the identification and development of novel therapeutic strategies for cancer with a particular focus on Acute myeloid leukemia (AML). AML is one of the most common forms of leukemia in adults and despite advances in treatment the median survival in patients over the age of 56 is less than one year. One of the major problems is that elderly patients frequently are not able to tolerate the current therapeutics which have high toxicities leaving them with no satisfactory options. Our laboratory is involved in elucidating novel therapeutic approaches to more specifically target AML cells to try to improve the efficacy and lessen the toxicities of AML therapy. In particular, we are actively investigating three approaches that involve ATP depletion-mediated differentiation, the design of novel nucleoside analogues that exhibit leukemic cell preferential uptake, and the targeting of a particular kinase that appears to be dysregulated in AML. We are currently conducting studies to both define the mechanisms of these strategies as well as to further assess their clinical potential using both in vitro and mouse in vivo based approaches. External Appointments Title Physician, Department of Pathology, Clinical Organization/Publication University Hospitals Publications View All Publications Xiao, H., Gulen, M. F., Qin, J., Yao, J., Bulek, K., Kish, D., Altuntas, C. Z., Wald, D., Ma, C., Zhou, H., Tuohy, V. K., Fairchild, R. L., de la Motte, C., Cua, D., Vallance, B. A., Li, X. "The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis.." Immunity. 2007 Apr;26(4):461-75. Epub 2007 Mar 29. Gregory, T. K., Wald, D., Chen, Y., Vermaat, J. M., Xiong, Y., Tse, W. "Molecular prognostic markers for adult acute myeloid leukemia with normal cytogenetics.." J Hematol Oncol. 2009 Jun 2;2:23. doi: 10.1186/[contact withheld]. Education Doctor of Medicine Case Western Reserve University Pathology 2005 Bachelor of Science Cornell University 1997 Residencies, Internships and Fellowships Clinical Pathology University Hospitals Case Medical Center Additional Information View External Profile
Education record: Case Western Reserve University
David Wald, MD, PhD Email [contact withheld] Phone [contact withheld] Fax Number [contact withheld] Professor, Department of Pathology, School of Medicine Co-Leader, Immune Oncology Program, Case Comprehensive Cancer Center David Wald graduated from Cornell University in 1997. He then matriculated to Case Western Reserve University as an MSTP Student. While a graduate student, he studied Toll-like receptor signaling ultimately attaining a Ph.D. in Pathology. After the completion of his medical school requirements, Dr. Wald continued his clinical training in Clinical Pathology at University Hospitals Cleveland Medical Center. Dr. Wald also conducted postdoctoral research in the laboratories of Drs. Bryan Roth and William Tse. While in these laboratories, Dr. Wald developed an interest in cancer drug development and began to identify novel drug candidates for Acute Myeloid Leukemia and to explore their mechanisms of action. In 2008, Dr. Wald joined Case Western Reserve University's Department of Pathology. My area of investigation includes cellular therapies for cancer, cancer drug development, and genetic and molecular analyses of leukemia. David Wald's Biography Research Information Research Projects Our research efforts are centered around the identification and development of novel therapeutic strategies for cancer with a particular focus on Acute myeloid leukemia (AML). AML is one of the most common forms of leukemia in adults and despite advances in treatment the median survival in patients over the age of 56 is less than one year. One of the major problems is that elderly patients frequently are not able to tolerate the current therapeutics which have high toxicities leaving them with no satisfactory options. Our laboratory is involved in elucidating novel therapeutic approaches to more specifically target AML cells to try to improve the efficacy and lessen the toxicities of AML therapy. In particular, we are actively investigating three approaches that involve ATP depletion-mediated differentiation, the design of novel nucleoside analogues that exhibit leukemic cell preferential uptake, and the targeting of a particular kinase that appears to be dysregulated in AML. We are currently conducting studies to both define the mechanisms of these strategies as well as to further assess their clinical potential using both in vitro and mouse in vivo based approaches. External Appointments Title Physician, Department of Pathology, Clinical Organization/Publication University Hospitals Publications View All Publications Xiao, H., Gulen, M. F., Qin, J., Yao, J., Bulek, K., Kish, D., Altuntas, C. Z., Wald, D., Ma, C., Zhou, H., Tuohy, V. K., Fairchild, R. L., de la Motte, C., Cua, D., Vallance, B. A., Li, X. "The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis.." Immunity. 2007 Apr;26(4):461-75. Epub 2007 Mar 29. Gregory, T. K., Wald, D., Chen, Y., Vermaat, J. M., Xiong, Y., Tse, W. "Molecular prognostic markers for adult acute myeloid leukemia with normal cytogenetics.." J Hematol Oncol. 2009 Jun 2;2:23. doi: 10.1186/[contact withheld]. Education Doctor of Medicine Case Western Reserve University Pathology 2005 Bachelor of Science Cornell University 1997 Residencies, Internships and Fellowships Clinical Pathology University Hospitals Case Medical Center Additional Information View External Profile
Education record: Clinical Pathology at University Hospitals Cleveland Medical Center
David Wald, MD, PhD Email [contact withheld] Phone [contact withheld] Fax Number [contact withheld] Professor, Department of Pathology, School of Medicine Co-Leader, Immune Oncology Program, Case Comprehensive Cancer Center David Wald graduated from Cornell University in 1997. He then matriculated to Case Western Reserve University as an MSTP Student. While a graduate student, he studied Toll-like receptor signaling ultimately attaining a Ph.D. in Pathology. After the completion of his medical school requirements, Dr. Wald continued his clinical training in Clinical Pathology at University Hospitals Cleveland Medical Center. Dr. Wald also conducted postdoctoral research in the laboratories of Drs. Bryan Roth and William Tse. While in these laboratories, Dr. Wald developed an interest in cancer drug development and began to identify novel drug candidates for Acute Myeloid Leukemia and to explore their mechanisms of action. In 2008, Dr. Wald joined Case Western Reserve University's Department of Pathology. My area of investigation includes cellular therapies for cancer, cancer drug development, and genetic and molecular analyses of leukemia. David Wald's Biography Research Information Research Projects Our research efforts are centered around the identification and development of novel therapeutic strategies for cancer with a particular focus on Acute myeloid leukemia (AML). AML is one of the most common forms of leukemia in adults and despite advances in treatment the median survival in patients over the age of 56 is less than one year. One of the major problems is that elderly patients frequently are not able to tolerate the current therapeutics which have high toxicities leaving them with no satisfactory options. Our laboratory is involved in elucidating novel therapeutic approaches to more specifically target AML cells to try to improve the efficacy and lessen the toxicities of AML therapy. In particular, we are actively investigating three approaches that involve ATP depletion-mediated differentiation, the design of novel nucleoside analogues that exhibit leukemic cell preferential uptake, and the targeting of a particular kinase that appears to be dysregulated in AML. We are currently conducting studies to both define the mechanisms of these strategies as well as to further assess their clinical potential using both in vitro and mouse in vivo based approaches. External Appointments Title Physician, Department of Pathology, Clinical Organization/Publication University Hospitals Publications View All Publications Xiao, H., Gulen, M. F., Qin, J., Yao, J., Bulek, K., Kish, D., Altuntas, C. Z., Wald, D., Ma, C., Zhou, H., Tuohy, V. K., Fairchild, R. L., de la Motte, C., Cua, D., Vallance, B. A., Li, X. "The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis.." Immunity. 2007 Apr;26(4):461-75. Epub 2007 Mar 29. Gregory, T. K., Wald, D., Chen, Y., Vermaat, J. M., Xiong, Y., Tse, W. "Molecular prognostic markers for adult acute myeloid leukemia with normal cytogenetics.." J Hematol Oncol. 2009 Jun 2;2:23. doi: 10.1186/[contact withheld]. Education Doctor of Medicine Case Western Reserve University Pathology 2005 Bachelor of Science Cornell University 1997 Residencies, Internships and Fellowships Clinical Pathology University Hospitals Case Medical Center Additional Information View External Profile
Education record: David Wald graduated from Cornell University in 1997.
David Wald graduated from Cornell University in 1997.
Education record: Doctor of Medicine Case Western Reserve University Pathology 2005
David Wald, MD, PhD Email [contact withheld] Phone [contact withheld] Fax Number [contact withheld] Professor, Department of Pathology, School of Medicine Co-Leader, Immune Oncology Program, Case Comprehensive Cancer Center David Wald graduated from Cornell University in 1997. He then matriculated to Case Western Reserve University as an MSTP Student. While a graduate student, he studied Toll-like receptor signaling ultimately attaining a Ph.D. in Pathology. After the completion of his medical school requirements, Dr. Wald continued his clinical training in Clinical Pathology at University Hospitals Cleveland Medical Center. Dr. Wald also conducted postdoctoral research in the laboratories of Drs. Bryan Roth and William Tse. While in these laboratories, Dr. Wald developed an interest in cancer drug development and began to identify novel drug candidates for Acute Myeloid Leukemia and to explore their mechanisms of action. In 2008, Dr. Wald joined Case Western Reserve University's Department of Pathology. My area of investigation includes cellular therapies for cancer, cancer drug development, and genetic and molecular analyses of leukemia. David Wald's Biography Research Information Research Projects Our research efforts are centered around the identification and development of novel therapeutic strategies for cancer with a particular focus on Acute myeloid leukemia (AML). AML is one of the most common forms of leukemia in adults and despite advances in treatment the median survival in patients over the age of 56 is less than one year. One of the major problems is that elderly patients frequently are not able to tolerate the current therapeutics which have high toxicities leaving them with no satisfactory options. Our laboratory is involved in elucidating novel therapeutic approaches to more specifically target AML cells to try to improve the efficacy and lessen the toxicities of AML therapy. In particular, we are actively investigating three approaches that involve ATP depletion-mediated differentiation, the design of novel nucleoside analogues that exhibit leukemic cell preferential uptake, and the targeting of a particular kinase that appears to be dysregulated in AML. We are currently conducting studies to both define the mechanisms of these strategies as well as to further assess their clinical potential using both in vitro and mouse in vivo based approaches. External Appointments Title Physician, Department of Pathology, Clinical Organization/Publication University Hospitals Publications View All Publications Xiao, H., Gulen, M. F., Qin, J., Yao, J., Bulek, K., Kish, D., Altuntas, C. Z., Wald, D., Ma, C., Zhou, H., Tuohy, V. K., Fairchild, R. L., de la Motte, C., Cua, D., Vallance, B. A., Li, X. "The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis.." Immunity. 2007 Apr;26(4):461-75. Epub 2007 Mar 29. Gregory, T. K., Wald, D., Chen, Y., Vermaat, J. M., Xiong, Y., Tse, W. "Molecular prognostic markers for adult acute myeloid leukemia with normal cytogenetics.." J Hematol Oncol. 2009 Jun 2;2:23. doi: 10.1186/[contact withheld]. Education Doctor of Medicine Case Western Reserve University Pathology 2005 Bachelor of Science Cornell University 1997 Residencies, Internships and Fellowships Clinical Pathology University Hospitals Case Medical Center Additional Information View External Profile
Education record: graduate student
David Wald, MD, PhD Email [contact withheld] Phone [contact withheld] Fax Number [contact withheld] Professor, Department of Pathology, School of Medicine Co-Leader, Immune Oncology Program, Case Comprehensive Cancer Center David Wald graduated from Cornell University in 1997. He then matriculated to Case Western Reserve University as an MSTP Student. While a graduate student, he studied Toll-like receptor signaling ultimately attaining a Ph.D. in Pathology. After the completion of his medical school requirements, Dr. Wald continued his clinical training in Clinical Pathology at University Hospitals Cleveland Medical Center. Dr. Wald also conducted postdoctoral research in the laboratories of Drs. Bryan Roth and William Tse. While in these laboratories, Dr. Wald developed an interest in cancer drug development and began to identify novel drug candidates for Acute Myeloid Leukemia and to explore their mechanisms of action. In 2008, Dr. Wald joined Case Western Reserve University's Department of Pathology. My area of investigation includes cellular therapies for cancer, cancer drug development, and genetic and molecular analyses of leukemia. David Wald's Biography Research Information Research Projects Our research efforts are centered around the identification and development of novel therapeutic strategies for cancer with a particular focus on Acute myeloid leukemia (AML). AML is one of the most common forms of leukemia in adults and despite advances in treatment the median survival in patients over the age of 56 is less than one year. One of the major problems is that elderly patients frequently are not able to tolerate the current therapeutics which have high toxicities leaving them with no satisfactory options. Our laboratory is involved in elucidating novel therapeutic approaches to more specifically target AML cells to try to improve the efficacy and lessen the toxicities of AML therapy. In particular, we are actively investigating three approaches that involve ATP depletion-mediated differentiation, the design of novel nucleoside analogues that exhibit leukemic cell preferential uptake, and the targeting of a particular kinase that appears to be dysregulated in AML. We are currently conducting studies to both define the mechanisms of these strategies as well as to further assess their clinical potential using both in vitro and mouse in vivo based approaches. External Appointments Title Physician, Department of Pathology, Clinical Organization/Publication University Hospitals Publications View All Publications Xiao, H., Gulen, M. F., Qin, J., Yao, J., Bulek, K., Kish, D., Altuntas, C. Z., Wald, D., Ma, C., Zhou, H., Tuohy, V. K., Fairchild, R. L., de la Motte, C., Cua, D., Vallance, B. A., Li, X. "The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis.." Immunity. 2007 Apr;26(4):461-75. Epub 2007 Mar 29. Gregory, T. K., Wald, D., Chen, Y., Vermaat, J. M., Xiong, Y., Tse, W. "Molecular prognostic markers for adult acute myeloid leukemia with normal cytogenetics.." J Hematol Oncol. 2009 Jun 2;2:23. doi: 10.1186/[contact withheld]. Education Doctor of Medicine Case Western Reserve University Pathology 2005 Bachelor of Science Cornell University 1997 Residencies, Internships and Fellowships Clinical Pathology University Hospitals Case Medical Center Additional Information View External Profile
Education record: MSTP Student
David Wald, MD, PhD Email [contact withheld] Phone [contact withheld] Fax Number [contact withheld] Professor, Department of Pathology, School of Medicine Co-Leader, Immune Oncology Program, Case Comprehensive Cancer Center David Wald graduated from Cornell University in 1997. He then matriculated to Case Western Reserve University as an MSTP Student. While a graduate student, he studied Toll-like receptor signaling ultimately attaining a Ph.D. in Pathology. After the completion of his medical school requirements, Dr. Wald continued his clinical training in Clinical Pathology at University Hospitals Cleveland Medical Center. Dr. Wald also conducted postdoctoral research in the laboratories of Drs. Bryan Roth and William Tse. While in these laboratories, Dr. Wald developed an interest in cancer drug development and began to identify novel drug candidates for Acute Myeloid Leukemia and to explore their mechanisms of action. In 2008, Dr. Wald joined Case Western Reserve University's Department of Pathology. My area of investigation includes cellular therapies for cancer, cancer drug development, and genetic and molecular analyses of leukemia. David Wald's Biography Research Information Research Projects Our research efforts are centered around the identification and development of novel therapeutic strategies for cancer with a particular focus on Acute myeloid leukemia (AML). AML is one of the most common forms of leukemia in adults and despite advances in treatment the median survival in patients over the age of 56 is less than one year. One of the major problems is that elderly patients frequently are not able to tolerate the current therapeutics which have high toxicities leaving them with no satisfactory options. Our laboratory is involved in elucidating novel therapeutic approaches to more specifically target AML cells to try to improve the efficacy and lessen the toxicities of AML therapy. In particular, we are actively investigating three approaches that involve ATP depletion-mediated differentiation, the design of novel nucleoside analogues that exhibit leukemic cell preferential uptake, and the targeting of a particular kinase that appears to be dysregulated in AML. We are currently conducting studies to both define the mechanisms of these strategies as well as to further assess their clinical potential using both in vitro and mouse in vivo based approaches. External Appointments Title Physician, Department of Pathology, Clinical Organization/Publication University Hospitals Publications View All Publications Xiao, H., Gulen, M. F., Qin, J., Yao, J., Bulek, K., Kish, D., Altuntas, C. Z., Wald, D., Ma, C., Zhou, H., Tuohy, V. K., Fairchild, R. L., de la Motte, C., Cua, D., Vallance, B. A., Li, X. "The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis.." Immunity. 2007 Apr;26(4):461-75. Epub 2007 Mar 29. Gregory, T. K., Wald, D., Chen, Y., Vermaat, J. M., Xiong, Y., Tse, W. "Molecular prognostic markers for adult acute myeloid leukemia with normal cytogenetics.." J Hematol Oncol. 2009 Jun 2;2:23. doi: 10.1186/[contact withheld]. Education Doctor of Medicine Case Western Reserve University Pathology 2005 Bachelor of Science Cornell University 1997 Residencies, Internships and Fellowships Clinical Pathology University Hospitals Case Medical Center Additional Information View External Profile
Education record: postdoctoral research
David Wald, MD, PhD Email [contact withheld] Phone [contact withheld] Fax Number [contact withheld] Professor, Department of Pathology, School of Medicine Co-Leader, Immune Oncology Program, Case Comprehensive Cancer Center David Wald graduated from Cornell University in 1997. He then matriculated to Case Western Reserve University as an MSTP Student. While a graduate student, he studied Toll-like receptor signaling ultimately attaining a Ph.D. in Pathology. After the completion of his medical school requirements, Dr. Wald continued his clinical training in Clinical Pathology at University Hospitals Cleveland Medical Center. Dr. Wald also conducted postdoctoral research in the laboratories of Drs. Bryan Roth and William Tse. While in these laboratories, Dr. Wald developed an interest in cancer drug development and began to identify novel drug candidates for Acute Myeloid Leukemia and to explore their mechanisms of action. In 2008, Dr. Wald joined Case Western Reserve University's Department of Pathology. My area of investigation includes cellular therapies for cancer, cancer drug development, and genetic and molecular analyses of leukemia. David Wald's Biography Research Information Research Projects Our research efforts are centered around the identification and development of novel therapeutic strategies for cancer with a particular focus on Acute myeloid leukemia (AML). AML is one of the most common forms of leukemia in adults and despite advances in treatment the median survival in patients over the age of 56 is less than one year. One of the major problems is that elderly patients frequently are not able to tolerate the current therapeutics which have high toxicities leaving them with no satisfactory options. Our laboratory is involved in elucidating novel therapeutic approaches to more specifically target AML cells to try to improve the efficacy and lessen the toxicities of AML therapy. In particular, we are actively investigating three approaches that involve ATP depletion-mediated differentiation, the design of novel nucleoside analogues that exhibit leukemic cell preferential uptake, and the targeting of a particular kinase that appears to be dysregulated in AML. We are currently conducting studies to both define the mechanisms of these strategies as well as to further assess their clinical potential using both in vitro and mouse in vivo based approaches. External Appointments Title Physician, Department of Pathology, Clinical Organization/Publication University Hospitals Publications View All Publications Xiao, H., Gulen, M. F., Qin, J., Yao, J., Bulek, K., Kish, D., Altuntas, C. Z., Wald, D., Ma, C., Zhou, H., Tuohy, V. K., Fairchild, R. L., de la Motte, C., Cua, D., Vallance, B. A., Li, X. "The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis.." Immunity. 2007 Apr;26(4):461-75. Epub 2007 Mar 29. Gregory, T. K., Wald, D., Chen, Y., Vermaat, J. M., Xiong, Y., Tse, W. "Molecular prognostic markers for adult acute myeloid leukemia with normal cytogenetics.." J Hematol Oncol. 2009 Jun 2;2:23. doi: 10.1186/[contact withheld]. Education Doctor of Medicine Case Western Reserve University Pathology 2005 Bachelor of Science Cornell University 1997 Residencies, Internships and Fellowships Clinical Pathology University Hospitals Case Medical Center Additional Information View External Profile
Education record: ultimately attaining a Ph.D. in Pathology
ultimately attaining a Ph.D. in Pathology
Identity: David Wald
David Wald, MD, PhD Email [contact withheld] Phone [contact withheld] Fax Number [contact withheld] Professor, Department of Pathology, School of Medicine Co-Leader, Immune Oncology Program, Case Comprehensive Cancer Center David Wald graduated from Cornell University in 1997. He then matriculated to Case Western Reserve University as an MSTP Student. While a graduate student, he studied Toll-like receptor signaling ultimately attaining a Ph.D. in Pathology. After the completion of his medical school requirements, Dr. Wald continued his clinical training in Clinical Pathology at University Hospitals Cleveland Medical Center. Dr. Wald also conducted postdoctoral research in the laboratories of Drs. Bryan Roth and William Tse. While in these laboratories, Dr. Wald developed an interest in cancer drug development and began to identify novel drug candidates for Acute Myeloid Leukemia and to explore their mechanisms of action. In 2008, Dr. Wald joined Case Western Reserve University's Department of Pathology. My area of investigation includes cellular therapies for cancer, cancer drug development, and genetic and molecular analyses of leukemia. David Wald's Biography Research Information Research Projects Our research efforts are centered around the identification and development of novel therapeutic strategies for cancer with a particular focus on Acute myeloid leukemia (AML). AML is one of the most common forms of leukemia in adults and despite advances in treatment the median survival in patients over the age of 56 is less than one year. One of the major problems is that elderly patients frequently are not able to tolerate the current therapeutics which have high toxicities leaving them with no satisfactory options. Our laboratory is involved in elucidating novel therapeutic approaches to more specifically target AML cells to try to improve the efficacy and lessen the toxicities of AML therapy. In particular, we are actively investigating three approaches that involve ATP depletion-mediated differentiation, the design of novel nucleoside analogues that exhibit leukemic cell preferential uptake, and the targeting of a particular kinase that appears to be dysregulated in AML. We are currently conducting studies to both define the mechanisms of these strategies as well as to further assess their clinical potential using both in vitro and mouse in vivo based approaches. External Appointments Title Physician, Department of Pathology, Clinical Organization/Publication University Hospitals Publications View All Publications Xiao, H., Gulen, M. F., Qin, J., Yao, J., Bulek, K., Kish, D., Altuntas, C. Z., Wald, D., Ma, C., Zhou, H., Tuohy, V. K., Fairchild, R. L., de la Motte, C., Cua, D., Vallance, B. A., Li, X. "The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis.." Immunity. 2007 Apr;26(4):461-75. Epub 2007 Mar 29. Gregory, T. K., Wald, D., Chen, Y., Vermaat, J. M., Xiong, Y., Tse, W. "Molecular prognostic markers for adult acute myeloid leukemia with normal cytogenetics.." J Hematol Oncol. 2009 Jun 2;2:23. doi: 10.1186/[contact withheld]. Education Doctor of Medicine Case Western Reserve University Pathology 2005 Bachelor of Science Cornell University 1997 Residencies, Internships and Fellowships Clinical Pathology University Hospitals Case Medical Center Additional Information View External Profile
Professional role: Co-Leader, Immune Oncology Program, Case Comprehensive Cancer Center
David Wald, MD, PhD Email [contact withheld] Phone [contact withheld] Fax Number [contact withheld] Professor, Department of Pathology, School of Medicine Co-Leader, Immune Oncology Program, Case Comprehensive Cancer Center David Wald graduated from Cornell University in 1997. He then matriculated to Case Western Reserve University as an MSTP Student. While a graduate student, he studied Toll-like receptor signaling ultimately attaining a Ph.D. in Pathology. After the completion of his medical school requirements, Dr. Wald continued his clinical training in Clinical Pathology at University Hospitals Cleveland Medical Center. Dr. Wald also conducted postdoctoral research in the laboratories of Drs. Bryan Roth and William Tse. While in these laboratories, Dr. Wald developed an interest in cancer drug development and began to identify novel drug candidates for Acute Myeloid Leukemia and to explore their mechanisms of action. In 2008, Dr. Wald joined Case Western Reserve University's Department of Pathology. My area of investigation includes cellular therapies for cancer, cancer drug development, and genetic and molecular analyses of leukemia. David Wald's Biography Research Information Research Projects Our research efforts are centered around the identification and development of novel therapeutic strategies for cancer with a particular focus on Acute myeloid leukemia (AML). AML is one of the most common forms of leukemia in adults and despite advances in treatment the median survival in patients over the age of 56 is less than one year. One of the major problems is that elderly patients frequently are not able to tolerate the current therapeutics which have high toxicities leaving them with no satisfactory options. Our laboratory is involved in elucidating novel therapeutic approaches to more specifically target AML cells to try to improve the efficacy and lessen the toxicities of AML therapy. In particular, we are actively investigating three approaches that involve ATP depletion-mediated differentiation, the design of novel nucleoside analogues that exhibit leukemic cell preferential uptake, and the targeting of a particular kinase that appears to be dysregulated in AML. We are currently conducting studies to both define the mechanisms of these strategies as well as to further assess their clinical potential using both in vitro and mouse in vivo based approaches. External Appointments Title Physician, Department of Pathology, Clinical Organization/Publication University Hospitals Publications View All Publications Xiao, H., Gulen, M. F., Qin, J., Yao, J., Bulek, K., Kish, D., Altuntas, C. Z., Wald, D., Ma, C., Zhou, H., Tuohy, V. K., Fairchild, R. L., de la Motte, C., Cua, D., Vallance, B. A., Li, X. "The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis.." Immunity. 2007 Apr;26(4):461-75. Epub 2007 Mar 29. Gregory, T. K., Wald, D., Chen, Y., Vermaat, J. M., Xiong, Y., Tse, W. "Molecular prognostic markers for adult acute myeloid leukemia with normal cytogenetics.." J Hematol Oncol. 2009 Jun 2;2:23. doi: 10.1186/[contact withheld]. Education Doctor of Medicine Case Western Reserve University Pathology 2005 Bachelor of Science Cornell University 1997 Residencies, Internships and Fellowships Clinical Pathology University Hospitals Case Medical Center Additional Information View External Profile
Co-Leader, Immune Oncology Program, Case Comprehensive Cancer Center
Professional role: Physician, Department of Pathology, Clinical
David Wald, MD, PhD Email [contact withheld] Phone [contact withheld] Fax Number [contact withheld] Professor, Department of Pathology, School of Medicine Co-Leader, Immune Oncology Program, Case Comprehensive Cancer Center David Wald graduated from Cornell University in 1997. He then matriculated to Case Western Reserve University as an MSTP Student. While a graduate student, he studied Toll-like receptor signaling ultimately attaining a Ph.D. in Pathology. After the completion of his medical school requirements, Dr. Wald continued his clinical training in Clinical Pathology at University Hospitals Cleveland Medical Center. Dr. Wald also conducted postdoctoral research in the laboratories of Drs. Bryan Roth and William Tse. While in these laboratories, Dr. Wald developed an interest in cancer drug development and began to identify novel drug candidates for Acute Myeloid Leukemia and to explore their mechanisms of action. In 2008, Dr. Wald joined Case Western Reserve University's Department of Pathology. My area of investigation includes cellular therapies for cancer, cancer drug development, and genetic and molecular analyses of leukemia. David Wald's Biography Research Information Research Projects Our research efforts are centered around the identification and development of novel therapeutic strategies for cancer with a particular focus on Acute myeloid leukemia (AML). AML is one of the most common forms of leukemia in adults and despite advances in treatment the median survival in patients over the age of 56 is less than one year. One of the major problems is that elderly patients frequently are not able to tolerate the current therapeutics which have high toxicities leaving them with no satisfactory options. Our laboratory is involved in elucidating novel therapeutic approaches to more specifically target AML cells to try to improve the efficacy and lessen the toxicities of AML therapy. In particular, we are actively investigating three approaches that involve ATP depletion-mediated differentiation, the design of novel nucleoside analogues that exhibit leukemic cell preferential uptake, and the targeting of a particular kinase that appears to be dysregulated in AML. We are currently conducting studies to both define the mechanisms of these strategies as well as to further assess their clinical potential using both in vitro and mouse in vivo based approaches. External Appointments Title Physician, Department of Pathology, Clinical Organization/Publication University Hospitals Publications View All Publications Xiao, H., Gulen, M. F., Qin, J., Yao, J., Bulek, K., Kish, D., Altuntas, C. Z., Wald, D., Ma, C., Zhou, H., Tuohy, V. K., Fairchild, R. L., de la Motte, C., Cua, D., Vallance, B. A., Li, X. "The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis.." Immunity. 2007 Apr;26(4):461-75. Epub 2007 Mar 29. Gregory, T. K., Wald, D., Chen, Y., Vermaat, J. M., Xiong, Y., Tse, W. "Molecular prognostic markers for adult acute myeloid leukemia with normal cytogenetics.." J Hematol Oncol. 2009 Jun 2;2:23. doi: 10.1186/[contact withheld]. Education Doctor of Medicine Case Western Reserve University Pathology 2005 Bachelor of Science Cornell University 1997 Residencies, Internships and Fellowships Clinical Pathology University Hospitals Case Medical Center Additional Information View External Profile
Professional role: Professor, Department of Pathology, School of Medicine
David Wald, MD, PhD Email [contact withheld] Phone [contact withheld] Fax Number [contact withheld] Professor, Department of Pathology, School of Medicine Co-Leader, Immune Oncology Program, Case Comprehensive Cancer Center David Wald graduated from Cornell University in 1997. He then matriculated to Case Western Reserve University as an MSTP Student. While a graduate student, he studied Toll-like receptor signaling ultimately attaining a Ph.D. in Pathology. After the completion of his medical school requirements, Dr. Wald continued his clinical training in Clinical Pathology at University Hospitals Cleveland Medical Center. Dr. Wald also conducted postdoctoral research in the laboratories of Drs. Bryan Roth and William Tse. While in these laboratories, Dr. Wald developed an interest in cancer drug development and began to identify novel drug candidates for Acute Myeloid Leukemia and to explore their mechanisms of action. In 2008, Dr. Wald joined Case Western Reserve University's Department of Pathology. My area of investigation includes cellular therapies for cancer, cancer drug development, and genetic and molecular analyses of leukemia. David Wald's Biography Research Information Research Projects Our research efforts are centered around the identification and development of novel therapeutic strategies for cancer with a particular focus on Acute myeloid leukemia (AML). AML is one of the most common forms of leukemia in adults and despite advances in treatment the median survival in patients over the age of 56 is less than one year. One of the major problems is that elderly patients frequently are not able to tolerate the current therapeutics which have high toxicities leaving them with no satisfactory options. Our laboratory is involved in elucidating novel therapeutic approaches to more specifically target AML cells to try to improve the efficacy and lessen the toxicities of AML therapy. In particular, we are actively investigating three approaches that involve ATP depletion-mediated differentiation, the design of novel nucleoside analogues that exhibit leukemic cell preferential uptake, and the targeting of a particular kinase that appears to be dysregulated in AML. We are currently conducting studies to both define the mechanisms of these strategies as well as to further assess their clinical potential using both in vitro and mouse in vivo based approaches. External Appointments Title Physician, Department of Pathology, Clinical Organization/Publication University Hospitals Publications View All Publications Xiao, H., Gulen, M. F., Qin, J., Yao, J., Bulek, K., Kish, D., Altuntas, C. Z., Wald, D., Ma, C., Zhou, H., Tuohy, V. K., Fairchild, R. L., de la Motte, C., Cua, D., Vallance, B. A., Li, X. "The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis.." Immunity. 2007 Apr;26(4):461-75. Epub 2007 Mar 29. Gregory, T. K., Wald, D., Chen, Y., Vermaat, J. M., Xiong, Y., Tse, W. "Molecular prognostic markers for adult acute myeloid leukemia with normal cytogenetics.." J Hematol Oncol. 2009 Jun 2;2:23. doi: 10.1186/[contact withheld]. Education Doctor of Medicine Case Western Reserve University Pathology 2005 Bachelor of Science Cornell University 1997 Residencies, Internships and Fellowships Clinical Pathology University Hospitals Case Medical Center Additional Information View External Profile
Professor, Department of Pathology, School of Medicine
Official profile: Official profile
David Wald, MD, PhD Email [contact withheld] Phone [contact withheld] Fax Number [contact withheld] Professor, Department of Pathology, School of Medicine Co-Leader, Immune Oncology Program, Case Comprehensive Cancer Center David Wald graduated from Cornell University in 1997. He then matriculated to Case Western Reserve University as an MSTP Student. While a graduate student, he studied Toll-like receptor signaling ultimately attaining a Ph.D. in Pathology. After the completion of his medical school requirements, Dr. Wald continued his clinical training in Clinical Pathology at University Hospitals Cleveland Medical Center. Dr. Wald also conducted postdoctoral research in the laboratories of Drs. Bryan Roth and William Tse. While in these laboratories, Dr. Wald developed an interest in cancer drug development and began to identify novel drug candidates for Acute Myeloid Leukemia and to explore their mechanisms of action. In 2008, Dr. Wald joined Case Western Reserve University's Department of Pathology. My area of investigation includes cellular therapies for cancer, cancer drug development, and genetic and molecular analyses of leukemia. David Wald's Biography Research Information Research Projects Our research efforts are centered around the identification and development of novel therapeutic strategies for cancer with a particular focus on Acute myeloid leukemia (AML). AML is one of the most common forms of leukemia in adults and despite advances in treatment the median survival in patients over the age of 56 is less than one year. One of the major problems is that elderly patients frequently are not able to tolerate the current therapeutics which have high toxicities leaving them with no satisfactory options. Our laboratory is involved in elucidating novel therapeutic approaches to more specifically target AML cells to try to improve the efficacy and lessen the toxicities of AML therapy. In particular, we are actively investigating three approaches that involve ATP depletion-mediated differentiation, the design of novel nucleoside analogues that exhibit leukemic cell preferential uptake, and the targeting of a particular kinase that appears to be dysregulated in AML. We are currently conducting studies to both define the mechanisms of these strategies as well as to further assess their clinical potential using both in vitro and mouse in vivo based approaches. External Appointments Title Physician, Department of Pathology, Clinical Organization/Publication University Hospitals Publications View All Publications Xiao, H., Gulen, M. F., Qin, J., Yao, J., Bulek, K., Kish, D., Altuntas, C. Z., Wald, D., Ma, C., Zhou, H., Tuohy, V. K., Fairchild, R. L., de la Motte, C., Cua, D., Vallance, B. A., Li, X. "The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis.." Immunity. 2007 Apr;26(4):461-75. Epub 2007 Mar 29. Gregory, T. K., Wald, D., Chen, Y., Vermaat, J. M., Xiong, Y., Tse, W. "Molecular prognostic markers for adult acute myeloid leukemia with normal cytogenetics.." J Hematol Oncol. 2009 Jun 2;2:23. doi: 10.1186/[contact withheld]. Education Doctor of Medicine Case Western Reserve University Pathology 2005 Bachelor of Science Cornell University 1997 Residencies, Internships and Fellowships Clinical Pathology University Hospitals Case Medical Center Additional Information View External Profile
Research interests: identification and development of novel therapeutic strategies for cancer with a particular focus on Acute myeloid leukemia (AML)
identification and development of novel therapeutic strategies for cancer with a particular focus on Acute myeloid leukemia (AML)
Research interests: My area of investigation includes cellular therapies for cancer, cancer drug development, and genetic and molecular analyses of leukemia.
My area of investigation includes cellular therapies for cancer, cancer drug development, and genetic and molecular analyses of leukemia.