Barbara D Lipes

An entirely cell-based system to generate single-chain antibodies against cell surface receptors

Angiostatin-like activity of a monoclonal antibody to the catalytic subunit of F1F0 ATP synthase

An integrated antigen discovery and CAR engineering pipeline enables PTPRZ1-targeted cellular therapy for glioblastoma

Barbara D. Lipes is a Duke University assistant professor in medicine affiliated with cardiology. She earned a Ph.D. from the University of North Carolina, Chapel Hill, in 1995. Her research centers on antibody engineering, including creating and screening antibodies that bind secreted glycoproteins. Her publication record spans single-chain antibody-generation systems, recombinant antibodies against toll-like receptors, ultrasensitive Ebola diagnostics, engineered cardiac tissue responses to COVID-19 variants, and recent PTPRZ1-directed CAR T-cell studies addressing glioblastoma heterogeneity and plasticity. Current research activities listed in Duke materials include diagnostic antibodies for Chagas disease, point-of-care testing for Lassa and other hemorrhagic fever arenaviruses, and work harnessing B cells to produce novel CAR-T cells.

Differential Response of Engineered Human Cardiac Tissues to Delta and Omicron COVID-19 Virus

Dual antigen transfer pathways mediate highly efficacious anti-tumor immunity induced by intravenously injected antigen loaded monocytes

EXTH-68. Targeting Tumor Heterogeneity And Plasticity in Glioblastoma With Novel CAR T Cells Targeting PTPRZ1

Identification of recombinant antibodies against multiple distinct toll-like receptors by homolog mining a single immune scFv phage library

Ultrasensitive point-of-care immunoassay for secreted glycoprotein detects Ebola infection earlier than PCR