Antonio Abbate

C. Heede Professor of Cardiology, Medicine- Cardiovascular Medicine · University of Virginia Medical Center

Credentials: · · · ·

History

Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19
Review · Nature reviews. Immunology · 2021 · Last of 11 authors · 776 citations
Interleukin-1 and the Inflammasome as Therapeutic Targets in Cardiovascular Disease
Review · Circulation Research · 2020 · First of 6 authors · 614 citations
The NLRP3 inflammasome in acute myocardial infarction
Review · Nature Reviews Cardiology · 2018 · 565 citations

Modeling of Cell-Specific LRP1 Signaling in Acute Myocardial Infarction
National Heart, Lung, and Blood Institute · R01
PI · $2.3M · University of Virginia
2024–2028
Targeted Interleukin-1 Blockade in Acute Systolic Heart Failure
National Heart, Lung, and Blood Institute · R61
PI · $752.4K · Virginia Commonwealth University
2026–2027
Prevention of Heart Failure with IL-1 Blockade: A Mechanistic Study
National Institute on Aging · R01
PI · $3.1M · Virginia Commonwealth University
2022–2027
Unconventional IL-1 Signaling in Heart Failure
National Heart, Lung, and Blood Institute · R01
Contact PI · $1.9M · University of Virginia
2020–2026

Pilot Study of IC14 (Atibuclimab), an Anti-CD14 Monoclonal Antibody, to Treat STEMI
Principal investigator · Active not recruiting · Phase 1, Phase 2
Implicit Bioscience
2025–2026
IC14 for Treatment of Acute Decompensated Heart Failure
Principal investigator · Active not recruiting · Phase 1, Phase 2
Implicit Bioscience
2024–2026
Colchicine in Acutely Decompensated HFREF
Principal investigator · Recruiting · Phase 4
University of Virginia
2024–2028
Mavrilimumab to Reduce Progression of Acute Respiratory Failure in COVID-19 Pneumonia and Systemic Hyper-inflammation
Principal investigator · Completed · Phase 2
Virginia Commonwealth University
2020