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Brent Hanks

Adjunct Associate Professor in the Department of Medicine · Duke University Hospital

Credentials: · · · ·

History

Duke University Hospital
Present
University of North Carolina Hospitals
Present
University of North Carolina Hospitals
Present

Internal Medicine
Duke University Hospital
2019–2022
Duke University Hospital
2008–2012
Baylor College of Medicine
Baylor College of Medicine
2002–2006

Research

Tumor Mutational Burden as a Predictor of Immunotherapy Response: Is More Always Better?
Clinical Cancer Research · 2021 · 343 citations
Durable Tumor Regression and Overall Survival in Patients With Advanced Merkel Cell Carcinoma Receiving Pembrolizumab as First-Line Therapy
Journal of Clinical Oncology · 2019 · 300 citations
Paracrine Wnt5a-β-Catenin Signaling Triggers a Metabolic Program that Drives Dendritic Cell Tolerization
Immunity · 2018 · Last of 12 authors · Corresponding · 245 citations

Nicholas DeVito
17 papers
April Salama
16 papers
Georgia Beasley
15 papers
Douglas Tyler
6 papers · 2 as a fellow
John Strickler
6 papers
Michael Morse
6 papers
Paul Mosca
5 papers
Adil Daud
4 papers
Douglas Johnson
4 papers
ES
Elad Sharon
3 papers
Gerard Blobe
3 papers
Hope Uronis
3 papers

Grants

Investigating the PD-L1:NLRP3 Signaling Axis as a Tumor Intrinsic Mechanism of Adaptive Resistance to Anti-PD-1 Antibody Immunotherapy
National Cancer Institute · R37
Contact PI · $2.5M · Univ of North Carolina Chapel Hill
2020–2027
Role of the Tumor NLRP3 Inflammasome in the Generation of Anti-PD-1 Antibody Immunotherapy-Associated Toxicities
National Cancer Institute · R01
Contact PI · $1.9M · Univ of North Carolina Chapel Hill
2021–2026
Melanoma-Mediated Dendritic Cell Tolerization and Immune Evasion
National Cancer Institute · K08
Contact PI · $825.7K · Duke University
2015–2020

Clinical trials

Immune-Related Adverse Events and Associated Biomarkers in Patients Receiving Cancer Immunotherapy
Principal investigator · Completed
Duke University
2022–2024
Understanding Immunotherapy Resistance Mechanisms in Advanced Melanoma
Principal investigator · Completed
Duke University
2016–2023