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Darius Ebrahimi-Fakhari

Director, Movement Disorders Program, Boston Children’s · Boston Childrens Hospital

Credentials: · · · ·

History

Movement Disorders Program · Boston Childrens Hospital
Present

Child Neurology
Boston Children's Hospital
2016–2020
Doctor of Medicine
2009–2013

Research

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Autophagy · 2016 · 4,439 citations
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
Autophagy · 2021 · 2,291 citations
Distinct roles in vivo for the ubiquitin-proteasome system and the autophagy-lysosomal pathway in the degradation of α-synuclein
Journal of Neuroscience · 2011 · First of 8 authors · 320 citations

MS
Mustafa Sahin
38 papers
KY
Kathryn Yang
35 papers · 35 as a resident
Lara Wahlster
17 papers · 5 as a resident
Luca Schierbaum
17 papers · 14 as a resident
SS
Siddharth Srivastava
10 papers · 6 as a fellow
ZZ
Zainab Zaman
10 papers · 3 as a resident
Craig Blackstone
7 papers
SS
Scellig Stone
7 papers
WN
Weston Northam
7 papers · 1 as a fellow
PP
Phillip Pearl
6 papers
Wendy Chung
6 papers
Daniel Calame
5 papers · 2 as a fellow

Grants

Spastic Paraplegia Centers of Excellence Research Network (SP-CERN) - RDCRC
National Institute of Neurological Disorders and Stroke · U54
Contact PI · $3.4M · Boston Children's Hospital
2025–2030
Development of a Translational Research Platform to Understand and Treat Defective Protein Trafficking in Childhood-Onset Hereditary Spastic Paraplegia
National Institute of Neurological Disorders and Stroke · K08
Contact PI · $1.1M · Boston Children's Hospital
2021–2026

Clinical trials

Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq)
Principal investigator · Recruiting
Boston Children's Hospital
2022–2027
Safety and Efficacy of AAV9/AP4B1 (BFB-101) For Patients With AP4B1-related Hereditary Spastic Paraplegia Type 47 (SPG47)
Site PI · Not yet recruiting · Phase 1, Phase 2
BlackfinBio Ltd
2025–2032
A Retrospective Survey-based Multicenter Study to Delineate the Molecular and Phenotypic Spectrum of Epilepsy-dyskinesia Syndromes
Site PI · Recruiting
Boston Children's Hospital
2024–2029
Registry and Natural History Study for Early Onset Hereditary Spastic Paraplegia
Site PI · Recruiting
Boston Children's Hospital
2020–2030