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David Deyle

Associate Professor of Medical Genetics · Mayo Clinic College of Medicine and Science

Credentials: · · · ·

History

Mayo Clinic College of Medicine and Science
Present

Medical Genetics and Genomics
University of Washington School of Medicine
2004–2005
Internal Medicine-Pediatrics
University of Minnesota
2000–2004
Univ of Minnesota, Duluth Sch of Med
1996–2000

Research

Adeno-associated virus vector integration
Review · Current opinion in molecular therapeutics · 2009 · First of 2 authors · 193 citations
Epigenetic Control of Skeletal Development by the Histone Methyltransferase Ezh2
Journal of Biological Chemistry · 2015 · 143 citations
High-resolution molecular validation of self-renewal and spontaneous differentiation in clinical-grade adipose-tissue derived human mesenchymal stem cells
Journal of Cellular Biochemistry · 2014 · 139 citations

DB
Dusica Babovic-Vuksanovic
5 papers
Pavel Pichurin
5 papers
Brendan Lanpher
4 papers
Heidi Connolly
4 papers
Ralitza Gavrilova
4 papers
Alberto Pochettino
3 papers
Elizabeth Stephens
3 papers · 1 as a fellow
Joseph Dearani
3 papers
Konstantinos Lazaridis
3 papers
Lisa Schimmenti
3 papers
Radhika Dhamija
3 papers
SR
Scott Riester
3 papers · 1 as a resident

Grants

In Vivo Gene Targeting to Treat Inherited Bone Disease
National Institute of Arthritis and Musculoskeletal and Skin Diseases · R01
Contact PI · $1.8M · Mayo Clinic Rochester
2015–2022
Development and Characterization of a Preclinical Swine Model of Osteogenesis Imperfecta
National Institute of Dental and Craniofacial Research · R43
PI · $224.8K · Recombinetics, Inc.
2019–2021
Engineering Pluripotent Stem Cells to Treat Osteogenesis Imperfecta
National Institute of Arthritis and Musculoskeletal and Skin Diseases · R03
Contact PI · $238.5K · Mayo Clinic Rochester
2014–2017
Gene Targeting with AAV Vectors for the Treatment of Osteogenesis Imperfecta
National Institute of Arthritis and Musculoskeletal and Skin Diseases · K08
Contact PI · $657.6K · Mayo Clinic Rochester
2008–2013

Clinical trials

AAVrh10-PCCA Gene Therapy for Propionic Acidemia
Principal investigator · Recruiting · Phase 1
Mayo Clinic
2026–2033
An Extension Study Assessing the Safety and Efficacy of AVTX-803 in Subjects With Leukocyte Adhesion Deficiency Type II
Principal investigator · Recruiting · Phase 3
AUG Therapeutics
2023–2026
A Study to Evaluate Efficacy and Safety of AVTX-803 in Patients With Leukocyte Adhesion Deficiency Type II
Principal investigator · Recruiting · Phase 3
AUG Therapeutics
2022–2026
Large-Scale Metabolomic Profiling for the Diagnosis of Inborn Errors of Metabolism
Principal investigator · Completed
Mayo Clinic
2019–2025