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David Williams

President, Dana-Farber/Boston Children’s Cancer and Blood Disorders Center · Mass General Brigham

Credentials: · · · ·

History

Mass General Brigham
Present
Department of Pediatric Oncology · Mass General Brigham
Present
Hematology/Oncology Division · Boston Children's Hospital
Present

Pediatric Hematology Oncology
Boston Children's Hospital
1981–1984
Pediatrics
Cincinnati Children's Hospital Medical Center
1978–1981
Indiana University School of Medicine
1974–1978
Indiana State University

Research

Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts
Nature · 2004 · 1,612 citations
Stem cell factor is encoded at the Sl locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor
Cell · 1990 · 1,400 citations
Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production
Nature Genetics · 1995 · 802 citations

Jose Cancelas
28 papers
Stuart Orkin
17 papers
Akiko Shimamura
11 papers
Donald Kohn
11 papers
Franklin Smith
10 papers
JM
John Manis
10 papers
Erica Esrick
9 papers
LM
Lars Mueller
9 papers
Kenneth Cornetta
8 papers
Mervin Yoder
8 papers
RR
Raffaele Renella
8 papers
BL
Barry Luskey
6 papers · 3 as a fellow

Grants

Pediatric Bone Marrow Failure Network (pBMFN)
National Institute of Child Health and Human Development · U54
Project lead · $135.3K · Boston Children's Hospital
2026–2031
Pathophysiology of Human Blood Cells
National Heart, Lung, and Blood Institute · T32
Contact PI · $13.1M · Boston Children's Hospital
1975–2030
Gene Therapy for SCID-X1 with Low Dose Busulfan and a SIN-Lentiviral Vector
National Institute of Allergy and Infectious Diseases · U01
Contact PI · $5.2M · Boston Children's Hospital
2016–2029
A Phase III Randomized Trial Comparing Unrelated Donor Bone Marrow Transplantation with Immune Suppressive Therapy for Newly Diagnosed Pediatric and Young Adult Patients with Severe Aplastic Anemia
National Heart, Lung, and Blood Institute · UH3
Contact PI · $2.1M · Boston Children's Hospital
2022–2029

Clinical trials

A Trial Comparing Unrelated Donor BMT With IST for Pediatric and Young Adult Patients With Severe Aplastic Anemia (TransIT, BMT CTN 2202)
Principal investigator · Active not recruiting · Phase 3
Boston Children's Hospital
2023–2029
A Gene Transfer Study Inducing Fetal Hemoglobin in Sickle Cell Disease (GRASP, BMT CTN 2001)
Principal investigator · Active not recruiting · Phase 2
David Williams
2022–2027
A Study of the Efficacy and Safety of Hematopoietic Stem Cells Transduced With Lenti-D Lentiviral Vector for the Treatment of Cerebral Adrenoleukodystrophy (CALD)
Principal investigator · Completed · Phase 2, Phase 3
Genetix Biotherapeutics Inc.
2013–2021