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James Isaacs

Physician · Cleveland Clinic

Credentials: · · · ·

History

Cleveland Clinic
2022–Present

Duke University Hospital
2020–2022
Internal Medicine
Duke University School of Medicine
2016–2019
University of Chicago Division of the Biological Sciences, The Pritzker School of Medicine
2012–2016
University of Arizona
2008–2012

Research

Patient-derived micro-organospheres enable clinical precision oncology
Cell stem cell · 2022 · 176 citations
Transcriptional and epigenetic regulators of human CD8+ T cell function identified through orthogonal CRISPR screens
Nature Genetics · 2023 · 79 citations
Biomarkers of Immune Checkpoint Blockade Response in Triple-Negative Breast Cancer
Review · Current Treatment Options in Oncology · 2021 · First of 4 authors · 39 citations

Scott Antonia
6 papers
Elizabeth Gaughan
4 papers
BG
Brian Gastman
3 papers
Jeffrey Clarke
3 papers
Lucy Kennedy
3 papers
Maria Wei
3 papers
Jennifer Ko
2 papers
Neal Ready
2 papers
Pauline Funchain
2 papers
Ryan Sullivan
2 papers · 2 as a fellow
TT
Thach-Giao Truong
2 papers
Thomas Stinchcombe
2 papers

Clinical trials

Neoadjuvant-Adjuvant Pembrolizumab in Resectable Advanced Basal Cell Carcinoma of H&N
Principal investigator · Completed · Phase 1
Case Comprehensive Cancer Center
2020–2025
Nivolumab in Combination With Talazoparib in Melanoma and Mutations in BRCA or BRCA-ness Genes
Principal investigator · Completed · Phase 2
Case Comprehensive Cancer Center
2020–2023
Leveraging ctDNA Analysis to Improve Early Detection of Cancer Recurrence in the High-Risk Melanoma Setting
Principal investigator · Completed
Case Comprehensive Cancer Center
2019–2023