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Jane Little

Director of the Adult Sickle Cell Program · UNC-Chapel Hill

Credentials: · · · ·

History

Adult Sickle Cell Program · UNC-Chapel Hill
Present

Research

Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell…
Blood · 2006 · 504 citations
Hospitalization for pain in patients with sickle cell disease treated with sildenafil for elevated TRV and low exercise capacity
Blood · 2011 · 203 citations
The relationship between the severity of hemolysis, clinical manifestations and risk of death in 415 patients with sickle cell anemia in the US and Europe
Haematologica · 2013 · 172 citations

Mark Gladwin
17 papers
Sophie Lanzkron
15 papers
GK
Gregory Kato
14 papers
Roberto Machado
13 papers
Victor Gordeuk
12 papers
Deepa Manwani
11 papers
Claudia Morris
10 papers · 3 as a resident
Samuel Wilson
9 papers
JK
Julie Kanter
8 papers
Payal Desai
8 papers
James Taylor
7 papers · 3 as a fellow
Joshua Field
7 papers

Grants

Hypoxemia with Sleep in Sickle Cell Anemia-Prevalence, Clinical and Cellular Impact & Response to Therapy: A Multi-Site Prospective Study Accessing New Collaborative Pathways
National Heart, Lung, and Blood Institute · R01
Contact PI · $1.4M · Univ of North Carolina Chapel Hill
2025–2029
Standardized Monitoring of Cellular Adhesion to Improve Clinical Care in Sickle Cell Disease
National Heart, Lung, and Blood Institute · R01
Contact PI · $2M · Case Western Reserve University
2016–2022

Clinical trials

Hemoglobin Desaturation in Sickle Cell Disease
Principal investigator · Completed
University Hospitals Cleveland Medical Center
2018–2022
Age of Blood in Sickle Cell Transfusion
Principal investigator · Completed · Phase 2, Phase 3
University of North Carolina, Chapel Hill
2017–2024
Exhaled Carbon Monoxide as a Marker of Hemolysis in Sickle Cell Disease- an Exploratory Study
Principal investigator · Withdrawn
University Hospitals Cleveland Medical Center
2013–2016
Efficacy, Safety Study and Benefit of Alkali Therapy in Sickle Cell Disease
Principal investigator · Terminated · Phase 1
University Hospitals Cleveland Medical Center
2013–2019