Jayakrishna Ambati
Vice Chair for Research · University of Virginia Medical Center
Credentials: · · · ·
History
- Present
Center for · University of Virginia Medical Center
- Present
2016 – present · University of Virginia Medical Center
- 2000–2001
- 1998–1999
- 1994–1995
Preliminary or Transitional Year
Research
L1 drives IFN in senescent cells and promotes age-associated inflammation
Nature · 2019 · 1,028 citations
Mechanisms of age-related macular degeneration
Review · Neuron · 2012 · First of 2 authors · Corresponding · 790 citations
Age-related macular degeneration: etiology, pathogenesis, and therapeutic strategies
Review · Survey of Ophthalmology · 2003 · First of 5 authors · 750 citations
- BA
40 papers · 4 as a resident
19 papers
- BF
18 papers · 5 as a resident
- MK
17 papers · 10 as a resident
- JB
16 papers
14 papers · 3 as a resident
- DH
12 papers
- AA
9 papers
Grants
- 2023–2028
Cytosolic SINE Retrotransposable Element cDNA and Mitochondrial DNA in Aging Retina
National Institute on Aging · R01
Contact PI · $2.5M · University of Virginia
- 2022–2027
Defining the Role of SINE Retrotransposons and Inflammasome Activation in Alzheimer's Disease
National Institute on Aging · R01
Contact PI · $3.1M · University of Virginia
- 2020–2025
Nlrp3 Inflammasome Activation in Early Diabetic Retinopathy
National Eye Institute · R01
Contact PI · $3.2M · University of Virginia
- 2018–2024
Antigen-Independent Suppression of Ocular Angiogenesis via the Fc Receptor
National Eye Institute · R01
Contact PI · $2.2M · University of Virginia
Clinical trials
- 2011–2012
A Phase I Open Label Dose Escalation Trial of RNA-144101 in the Treatment of Geographic Atrophy
Principal investigator · Withdrawn · Phase 1
Mark Kleinman