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John Krystal

Psychiatry & Neurology / Psychiatry

Credentials: · ·

History

Addiction Psychiatry
Yale University
1984–1985
The University
Yale School of Medicine
1980–1984
The University of Alabama
1980–1984
Psychiatry
University of Chicago Medical Center
1976–1980

Research

Antidepressant effects of ketamine in depressed patients
Biological Psychiatry · 2000 · Last of 7 authors · 3,030 citations
Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses
Archives of General Psychiatry · 1994 · First of 9 authors · 2,718 citations
Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants
Nature Medicine · 2016 · Last of 4 authors · 1,403 citations

Dennis Charney
114 papers
SS
Steven Southwick
93 papers
Chadi Abdallah
62 papers · 1 as a resident
JG
Joel Gelernter
62 papers
IP
Ismene Petrakis
61 papers
DD
Deepak Dsouza
58 papers · 1 as a resident
Gerard Sanacora
46 papers · 10 as a resident
GH
George Heninger
41 papers
IH
Ilan Harpaz-Rotem
36 papers
Anissa Abi-Dargham
34 papers · 3 as a resident
LA
Lynnette Averill
33 papers
JS
John Seibyl
29 papers

Grants

Center for the Translational Neuroscience of Alcohol
National Institute on Alcohol Abuse and Alcoholism · P50
Contact PI · $42.1M · Yale University
2001–2031
AMPA Receptor Components of the Antidepressant Response to Ketamine in Humans
National Institute of Mental Health · R01
PI · $3.3M · Yale University
2023–2028
Yale Clinical and Translational Science Award (U Component)
National Center for Advancing Translational Sciences · UL1
PI · $84.7M · Yale University
2016–2027
A Translational and Neurocomputational Evaluation of a D1R Partial Agonist for Schizophrenia
National Institute of Mental Health · U01
Contact PI · $11.8M · Yale University
2019–2025

Clinical trials

Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response
Principal investigator · Recruiting · Phase 1
Yale University
2023–2032
A Translational and Neurocomputational Evaluation of a Dopamine Receptor 1 Partial Agonist for Schizophrenia
Principal investigator · Completed · Phase 2
Yale University
2021–2024
Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response, Pilot Trial
Principal investigator · Completed · Phase 1
Yale University
2018–2022
CAP-Ketamine for Antidepressant Resistant PTSD
Principal investigator · Completed · Phase 2
VA Office of Research and Development
2016–2020