John Letterio
Interim Director, UH Seidman Cancer Center · Case Western Reserve University/University Hospitals Cleveland Medical Center
Credentials: · · ·
History
PresentUH Seidman Cancer Center · Case Western Reserve University/University Hospitals Cleveland Medical Center
- Present
Angie Fowler Adolescent and Young Adult Cancer Institute Center · Case Western Reserve University/University Hospitals Cleveland Medical Center
- Present
Pediatric Hematology and Oncology Division · Case Western Reserve University/University Hospitals Cleveland Medical Center
- 1990–1993
National Cancer Institute Nci)
- 1978–1982
Research
Regulation of immune responses by TGF-beta
Review · Annual Review of Immunology · 1998 · First of 2 authors · 1,514 citations
TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells
The Journal of Experimental Medicine · 2005 · 796 citations
The EMBO Journal · 1999 · 730 citations
7 papers
- GL
6 papers
3 papers
3 papers
- RG
3 papers
- TB
3 papers
- AP
2 papers
2 papers
Grants
- 1997–2030
Case Comprehensive Cancer Center Support Grant
National Cancer Institute · P30
Project lead · $625.8K · Case Western Reserve University
- 2023–2025
Development of a Novel, CNS-Penetrant Synthetic Triterpenoid for Pediatric High-Grade Glioma.
National Cancer Institute · R21
Contact PI · $414K · Case Western Reserve University
- 2013–2018
Novel Mechanisms of Immune Activation Following Allogeneic, Hematopoietic Stem Ce
National Heart, Lung, and Blood Institute · R01
Contact PI · $1.6M · Case Western Reserve University
- 2015–2018
Cdk5 Signaling in ICN1-Induced T Cell Leukemogenesis
National Cancer Institute · R21
PI · $379.2K · Case Western Reserve University
Clinical trials
- 2021–2027
SEVENFACT® for Bleeding Events in Hemophilia With Inhibitors
Site PI · Recruiting · Phase 4
American Thrombosis and Hemostasis Network
- 2020–2035
ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic Disorders
Site PI · Recruiting
American Thrombosis and Hemostasis Network