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John O'Toole

Physician · Cleveland Clinic

Credentials: · · · ·

History

Cleveland Clinic
Present

University of Michigan
2001–2003
Internal Medicine
University of Iowa Hospitals and Clinics
1998–2001
University of Cincinnati College of Medicine
1994–1998
Boston College
1988–1992

Research

Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways
Cell · 2011 · 514 citations
Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination
Nature Genetics · 2003 · 499 citations
The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4
Nature Genetics · 2006 · 445 citations

John Sedor
43 papers
FH
Friedhelm Hildebrandt
19 papers
Laura Barisoni
11 papers · 4 as a resident
Matthias Kretzler
11 papers
Sethu Madhavan
11 papers
Sushrut Waikar
8 papers
Ian de Boer
7 papers · 3 as a fellow
Jeffrey Hodgin
7 papers
Jonathan Himmelfarb
7 papers
Sylvia Rosas
7 papers
Matthias Wolf
6 papers · 3 as a resident
CP
Chirag Parikh
5 papers

Grants

Cleveland Precision Medicine Chronic Kidney Disease Cohort
National Institute of Diabetes and Digestive and Kidney Diseases · U01
Contact PI · $2.2M · Cleveland Clinic Lerner Com-Cwru
2017–2027
Mechanisms of Kidney Diseases Associated With APOL1 Variation
National Institute of Diabetes and Digestive and Kidney Diseases · R01
PI · $2.7M · Cleveland Clinic Lerner Com-Cwru
2023–2026
Intracellular Functions of APOL1 in the Kidney
National Institute of Diabetes and Digestive and Kidney Diseases · R01
PI · $2.8M · Cleveland Clinic Lerner Com-Cwru
2021–2026
Cleveland Precision Medicine Chronic Kidney Disease Cohort
National Institute of Diabetes and Digestive and Kidney Diseases · UH3
Contact PI · $900K · Cleveland Clinic Lerner Com-Cwru
2017–2022

Clinical trials

Kidney Precision Medicine Project
Site PI · Recruiting
Icahn School of Medicine at Mount Sinai
2019–2027