
Matthew Semler
Associate Professor · Vanderbilt University Medical Center
Credentials: · · · ·
History
- 2011–2014
Pulmonary Disease and Critical Care Medicine



Research
Balanced Crystalloids versus Saline in Critically Ill Adults
New England Journal of Medicine · 2018 · First of 19 authors · 972 citations
Factors Associated With Death in Critically Ill Patients With Coronavirus Disease 2019 in the US
JAMA Internal Medicine · 2020 · 721 citations
Balanced Crystalloids versus Saline in Noncritically Ill Adults
New England Journal of Medicine · 2018 · 471 citations

147 papers

127 papers · 76 as a resident

94 papers

44 papers

39 papers

38 papers
- KS
35 papers · 29 as a fellow

33 papers · 6 as a fellow
Grants
- 2025–2030
Personalized Oxygen Therapy for Critically Ill Adults: A Randomized Trial
National Heart, Lung, and Blood Institute · R33
Contact PI · $874.1K · Vanderbilt University Medical Center
- 2025–2026
Personalized Oxygen Therapy for Critically Ill Adults: A Randomized Trial
National Heart, Lung, and Blood Institute · R61
Contact PI · $875K · Vanderbilt University Medical Center
- 2018–2023
Oxygen Saturation Targets During Mechanical Ventilation of Critically Ill Adults: A Clinical Trial
National Heart, Lung, and Blood Institute · K23
Contact PI · $853.6K · Vanderbilt University Medical Center
Clinical trials
- 2026–2030
Examination of Personalized SpO2 Targets
Principal investigator · Enrolling by invitation
Vanderbilt University Medical Center
- 2026–2028
Steroid Treatment for Severe Acute Respiratory Infection (STAR) Trial
Principal investigator · Not yet recruiting · Phase 4
National Institute of Allergy and Infectious Diseases (NIAID)
- 2023–2025
Effect of Direct-from-blood Bacterial Testing on Antibiotic Administration and Clinical Outcomes
Principal investigator · Completed
Vanderbilt University Medical Center
- 2022
DirEct Versus VIdeo LaryngosCopE Trial
Principal investigator · Completed
Vanderbilt University Medical Center



