Michael Knowles

Professor of Pulmonary and Critical Care Medicine · University of North Carolina at Chapel Hill

Credentials: · · ·

History

Mucus clearance as a primary innate defense mechanism for mammalian airways
Review · Journal of Clinical Investigation · 2002 · First of 2 authors · 895 citations
Relation between mutations of the cystic fibrosis gene and idiopathic pancreatitis
New England Journal of Medicine · 1998 · 703 citations
Primary ciliary dyskinesia: diagnostic and phenotypic features
American Journal of Respiratory and Critical Care Medicine · 2004 · Last of 8 authors · 551 citations

Genetic Disorders of Mucociliary Clearance
National Heart, Lung, and Blood Institute · U54
Contact PI · $14.7M · Univ of North Carolina Chapel Hill
2004–2024
Pathogenesis of PCD Lung Disease
National Heart, Lung, and Blood Institute · R01
Contact PI · $7.2M · Univ of North Carolina Chapel Hill
2004–2023
Mining Open Chromatin to Define Molecular Mechanisms of CF Modifier Genes
National Heart, Lung, and Blood Institute · R01
PI · $2.9M · Case Western Reserve University
2013–2019
Gene Modifiers in CF Lung Disease
National Heart, Lung, and Blood Institute · R01
Contact PI · $9.5M · Univ of North Carolina Chapel Hill
2001–2016

Genetics of Primary Ciliary Dyskinesia
Principal investigator · Completed
University of North Carolina, Chapel Hill
2015–2018
Molecular Phenotypes for Cystic Fibrosis Lung Disease
Principal investigator · Completed
University of North Carolina, Chapel Hill
2009–2023
Rare Genetic Disorders of the Breathing Airways
Principal investigator · Completed
University of North Carolina, Chapel Hill
2006–2012
Study of Uridine Triphosphate (UTP) as an Aerosol Spray for Cystic Fibrosis
Study chair · Completed
FDA Office of Orphan Products Development
1996–1999