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PG

Patrick Grohar

Physician · Children's Hospital of Philadelphia

Credentials: · · · · ·

History

Children's Hospital of Philadelphia
2024–Present

Hematology and Medical Oncology
2006–2009
Internal Medicine
2003–2006
Wayne State University School of Medicine
1999–2003

Research

Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism
Oncogene · 2007 · 645 citations
Identification of an inhibitor of the EWS-FLI1 oncogenic transcription factor by high-throughput screening
Journal of the National Cancer Institute · 2011 · First of 12 authors · Corresponding · 173 citations
Ecteinascidin 743 interferes with the activity of EWS-FLI1 in Ewing sarcoma cells
Neoplasia · 2011 · First of 8 authors · Corresponding · 111 citations

DR
Damon Reed
11 papers
Katherine Janeway
11 papers
LH
Lee Helman
11 papers
Steven DuBois
9 papers
Kelly Bailey
7 papers
Richard Gorlick
7 papers
Stephen Lessnick
7 papers
Brian Crompton
6 papers
Jenna Gedminas
6 papers · 3 as a fellow
Ryan Roberts
6 papers
David Shulman
5 papers
LM
Leo Mascarenhas
4 papers

Grants

The Interface of Transcription, DNA Damage and Epigenetics: A Therapeutic Vulnerability of the EWS-FLI1 Transcription Factor
National Cancer Institute · R01
Contact PI · $1.8M · University of Michigan at Ann Arbor
2023–2028
A Collaborative Approach to Analyze and Target the EWS-FLI1 Transcription Factor in Patients with Ewing Sarcoma
National Cancer Institute · U01
Contact PI · $2M · Sarc
2019–2024
Development of Trabectedin Analogs That Target the EWS-FLI1 Transcription Factor
National Cancer Institute · R01
Contact PI · $2M · Children's Hosp of Philadelphia
2015–2021

Clinical trials

SARC037: A Phase I/II Study to Evaluate the Safety of Trabectedin in Combination With Irinotecan in Ewing Sarcoma Patients
Principal investigator · Completed · Phase 1, Phase 2
Sarcoma Alliance for Research through Collaboration
2021–2025