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Priscilla Brastianos

Director, Central Nervous System Metastasis Program · University of Florida College of Medicine

Credentials: · · ·

History

Massachusetts General Hospital
Present

Dana-Farber Cancer Institute
2010–2012
Internal Medicine
Johns Hopkins Hospital
2006–2009
Johns Hopkins Univ Sch of Med
2002–2006

Research

An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma
Cell · 2019 · 2,158 citations
Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets
Cancer Discovery · 2015 · Co-first of 44 authors · 886 citations
Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq
Science · 2017 · 770 citations

Daniel Cahill
66 papers
Sandro Santagata
37 papers
Frederick Barker
29 papers
Maria Martinez-Lage
21 papers · 1 as a fellow
PW
Patrick Wen
20 papers
Tracy Batchelor
20 papers
William Curry
20 papers
Christopher Alvarez-Breckenridge
19 papers · 17 as a resident
EG
Elizabeth Gerstner
19 papers
Helen Shih
17 papers
Ian Dunn
17 papers · 13 as a resident
Ryan Sullivan
17 papers · 1 as a fellow

Grants

Elucidating Resistance Mechanisms and Enhancing Response to Immune Checkpoint Blockade in Central Nervous System Metastases from Breast Cancer
National Cancer Institute · R01
Contact PI · $3.5M · Massachusetts General Hospital
2024–2029
Using MRI and Circulating Tumor DNA to Improve the Interpretation of Response to Immunotherapy and Targeted Therapy in CNS Metastases
National Cancer Institute · R01
PI · $3.4M · Massachusetts General Hospital
2019–2025
Identification of Genomic Drivers of Brain Metastases in Lung Adenocarcinoma
National Cancer Institute · R01
Contact PI · $3.5M · Massachusetts General Hospital
2018–2024
Identification of Genomic Drivers of Brain Metastases in Renal Cell Carcinoma
National Cancer Institute · R21
Contact PI · $420.9K · Massachusetts General Hospital
2018–2021

Clinical trials

Ipilimumab and Nivolumab in Leptomeningeal Metastases
Principal investigator · Completed · Phase 2
Massachusetts General Hospital
2018–2021
Phase II Trial of Pembrolizumab in Recurrent or Residual High Grade Meningioma
Principal investigator · Active not recruiting · Phase 2
Massachusetts General Hospital
2017–2026
Genetic Testing in Guiding Treatment for Patients With Brain Metastases
Study chair · Active not recruiting · Phase 2
Alliance for Clinical Trials in Oncology
2019–2028
Vemurafenib and Cobimetinib in Treating Patients With BRAF V600E Mutation Positive Craniopharyngioma
Study chair · Active not recruiting · Phase 2
Alliance for Clinical Trials in Oncology
2018–2028