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Ralph DeFronzo

Chief, Diabetes Division · University of Texas Health Science Center San Antonio Joe and Teresa Lozano Long School of Medicine

Credentials: · ·

History

Diabetes Division · University of Texas Health Science Center San Antonio Joe and Teresa Lozano Long School of Medicine
Present
University of Texas Health Science Center San Antonio Joe and Teresa Lozano Long School of Medicine
Present
Medicine/Division Chief of Diabetes · University of Texas Health Science Center San Antonio Joe and Teresa Lozano Long School of Medicine
Present

Endocrinology, Diabetes, and Metabolism
Beth Israel Deaconess Medical Center
2022–2024
Gerontology Research Center
Hospital of the University of Pennsylvania
Internal Medicine
1968–1971
1969 - MS - Medicine (Cum Laude) - Boston College Graduate School of Biology
1969
Johns Hopkins Hospital
1967–1968
1967 - BMS - Medicine - Dartmouth Medical School
1963–1967
Yale University
1964

Research

Glucose clamp technique: a method for quantifying insulin secretion and resistance
American Journal of Physiology-Renal Physiology · 1979 · First of 3 authors · 7,044 citations
Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp
Diabetes Care · 1999 · 4,918 citations
Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease
Review · Diabetes Care · 1991 · First of 2 authors · 3,772 citations

EC
Eugenio Cersosimo
57 papers
Nicolas Musi
51 papers
Devjit Tripathy
49 papers · 2 as a resident
DS
Donald Simonson
35 papers · 10 as a fellow
Kenneth Cusi
27 papers
PF
Philip Felig
20 papers
Carolina Solis-Herrera
19 papers
Mandeep Bajaj
19 papers
RS
Robert Sherwin
18 papers
Eugene Barrett
16 papers
SK
Sangeeta Kashyap
16 papers
Aurora Merovci
15 papers · 5 as a resident

Grants

Identification of Cell Type-Specific Insulin Responsive Quantitative Trait Loci in Human Skeletal Muscle
National Institute of Diabetes and Digestive and Kidney Diseases · R01
PI · $707.8K · University of Texas Hlth Science Center
2026–2031
SGLT2 Inhibitors, Ketogenesis, and Ketoacidosis
National Institute of Diabetes and Digestive and Kidney Diseases · R01
Contact PI · $17.1M · University of Texas Hlth Science Center
1978–2027
Ketones, Muscle Metabolism, and SGLT2 Inhibitors
National Institute of Diabetes and Digestive and Kidney Diseases · R01
Contact PI · $5.9M · University of Texas Hlth Science Center
2016–2027
Targeting Hepatic Mitochondrial Function in Humans with NAFLD Using Insulin Sensitizers
National Institute of Diabetes and Digestive and Kidney Diseases · R01
PI · $3.4M · University of Texas Hlth Science Center
2022–2027

Clinical trials

SGLT2i, Pioglitazone, and Ketone Production in T1D
Principal investigator · Recruiting · Phase 3
The University of Texas Health Science Center at San Antonio
2026–2027
SGLT2i, Pioglitazone, and Ketone Production in T2D
Principal investigator · Recruiting · Phase 1
The University of Texas Health Science Center at San Antonio
2026–2027
SGLT2i, Ketoacidosis, Volume Contraction, and Insulinopenia
Principal investigator · Recruiting · Phase 1
The University of Texas Health Science Center at San Antonio
2025–2027
SGLT2i, Hepatic Glucose Production, and SNS
Principal investigator · Recruiting · Early phase 1
The University of Texas Health Science Center at San Antonio
2025–2027