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Sidharth Puram

Lindburg Professor and Chair, Department of Otolaryngology–Head and Neck Surgery · Washington University/B-JH/SLCH Consortium

Credentials: · · · · · · · ·

History

Department of Otolaryngology–Head and Neck Surgery · Washington University/B-JH/SLCH Consortium
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Robert Ebert and Greg Stubblefield Head and Neck Tumor Center · Washington University/B-JH/SLCH Consortium
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Washington University/B-JH/SLCH Consortium
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Ohio State University College of Medicine
2018–2019
Otolaryngology
Mass General Brigham
2013–2018
Harvard Medical School
Harvard Medical School
2009–2013
Biology and Neuroscience, Massachusetts Institute of Technology, Cambridge, MA
2005–2009

Research

Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer
Cell · 2017 · First of 19 authors · 2,086 citations
Hallmarks of transcriptional intratumour heterogeneity across a thousand tumours
Nature · 2023 · 426 citations
Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity
Nature Genetics · 2020 · 346 citations

Patrik Pipkorn
72 papers
Ryan Jackson
68 papers
Jason Rich
35 papers
Randal Paniello
24 papers
Anuraag Parikh
23 papers · 15 as a resident
Stephen Kang
23 papers · 19 as a resident
Douglas Adkins
22 papers
Jose Zevallos
22 papers
Paul Zolkind
22 papers
Wade Thorstad
22 papers
MV
Mark Varvares
21 papers
Joseph Zenga
20 papers

Grants

Senescent T Cells and Immunotherapy Resistance in Head and Neck Cancer
National Institute of Dental and Craniofacial Research · R01
PI · $615.9K · Washington University
2026–2031
CCR2 PET Imaging Head and Neck Squamous Cell Carcinoma
National Cancer Institute · R01
PI · $637.4K · Washington University
2026–2031
PET Imaging CD163+ Tumor Associated Macrophages in Head and Neck Cancer
National Cancer Institute · R01
PI · $623.6K · Washington University
2026–2031
Validating the Hybrid Epithelial/Mesenchymal State as a Biomarker of Treatment Response and Outcomes in Head and Neck Cancer
National Institute of Dental and Craniofacial Research · U01
Contact PI · $1.4M · Boston University (Charles River Campus)
2025–2030

Clinical trials

Ficerafusp Alfa, Pembrolizumab, and Stereotactic Body Radiotherapy (SBRT) for Head and Neck Squamous Cell Carcinoma (HNSCC)
Principal investigator · Not yet recruiting · Phase 1, Phase 2
Washington University School of Medicine
2026–2033
CCR2 PET Imaging Head and Neck Squamous Cell Carcinoma
Sub-investigator · Not yet recruiting · Phase 2
Washington University School of Medicine
2026–2032
Three Schedules of CUE-101 Administered Before Surgery or Definitive Chemoradiation Therapy in HLA-A*0201 Positive Patients With Locally Advanced, HPV16-Positive Oropharyngeal Squamous-Cell Carcinoma
Sub-investigator · Recruiting · Phase 2
Washington University School of Medicine
2021–2027
Circulating Tumor DNA (ctDNA) for Early Treatment Response Assessment of Solid Tumors
Sub-investigator · Recruiting
Washington University School of Medicine
2019–2026