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Simon Little

David A. Coulter Endowed Chair in Aging and Neurodegenerative Disease · University of California (San Francisco) School of Medicine

Credentials: · · ·

History

University of California (San Francisco) School of Medicine
Present

University College London
2008–2009
St Georges Hospital
2005–2008
St Thomas Hospital
2004–2005
University of Oxford
UCL Medical School
2000–2004
MBBS, University College London

Research

Adaptive deep brain stimulation in advanced Parkinson disease
Annals of Neurology · 2013 · First of 13 authors · 935 citations
The modulatory effect of adaptive deep brain stimulation on beta bursts in Parkinson's disease
Brain · 2017 · 334 citations
The functional role of beta oscillations in Parkinson's disease
Review · Parkinsonism & Related Disorders · 2014 · First of 2 authors · 319 citations

Philip Starr
54 papers
Jill Ostrem
14 papers
Lauren Hammer
9 papers · 3 as a fellow
Michael Okun
8 papers
AM
Adolfo Madrazo
7 papers
Helen Bronte-Stewart
6 papers
Joshua Wong
6 papers · 2 as a fellow
Kelly Foote
6 papers
Doris Wang
5 papers
RW
Robert Wilt
5 papers
Sarah Wang
5 papers
Gregory Worrell
4 papers

Grants

Simplified, Scalable 24-Hour Adaptive Deep Brain Stimulation for Parkinson’s Disease
National Institute of Neurological Disorders and Stroke · UH3
PI · $2.1M · University of California, San Francisco
2025–2029
Determining the Circuits and Signals of Sleep Dysfunction in Parkinson's Disease Through Chronic Intracranial Recordings and Closed-Loop Deep Brain Stimulation
National Institute of Neurological Disorders and Stroke · R01
Contact PI · $2.6M · University of California, San Francisco
2023–2028
Simplified, Scalable 24-Hour Adaptive Deep Brain Stimulation for Parkinson’s Disease
National Institute of Neurological Disorders and Stroke · UG3
PI · $1.4M · University of California, San Francisco
2025
Uncovering the Neurophysiology of Motivation in ParkinsonÃÂs Disease with Implanted Adaptive Brain Stimulation
National Institute of Neurological Disorders and Stroke · K23
Contact PI · $809.1K · University of California, San Francisco
2021–2025

Clinical trials

Automated Daytime Adaptive Deep Brain Stimulation Parameter Optimization in Patients Implanted With Percept Neurostimulator
Principal investigator · Recruiting
University of California, San Francisco
2026–2032
Simplified, Scalable, 24-hour Adaptive DBS in Parkinson's Disease
Principal investigator · Recruiting
University of California, San Francisco
2026–2031
Understanding Motivation in Parkinson's Patients Through Neurophysiology
Principal investigator · Recruiting
University of California, San Francisco
2021–2030
Cortical Stimulation to Treat Mood and Behavioral Symptoms in Parkinson's Disease Patients
Principal investigator · Completed
Simon J. Little, MBBS, PhD
2016–2024