Stephanie Seminara

Chief of the Reproductive Endocrine Unit · Massachusetts General Hospital

Credentials: · · · · ·

History

The GPR54 gene as a regulator of puberty
New England Journal of Medicine · 2003 · First of 20 authors · 1,950 citations
A role for kisspeptins in the regulation of gonadotropin secretion in the mouse
Endocrinology · 2004 · 908 citations
Increased hypothalamic GPR54 signaling: a potential mechanism for initiation of puberty in primates
Proceedings of the National Academy of Sciences of the United States of America · 2005 · 677 citations

Towards Curative Therapies for Hypogonadotropic Diseases
National Institute of Child Health and Human Development · R37
Contact PI · $5.8M · Massachusetts General Hospital
2003–2030
Phase 2 Kp-10 in Patients with Hypogonadotropic Hypogonadism
Food and Drug Administration · R01
Contact PI · $1.3M · Massachusetts General Hospital
2023–2028
Dissection of the Molecular Basis of Pleiotropy Between GnRH Neuronal Development and Cranial Suture Fusion
National Institute of Dental and Craniofacial Research · R01
Contact PI · $790.4K · Massachusetts General Hospital
2022–2027
The Massachusetts General Hospital Harvard Center for Reproductive Medicine
National Institute of Child Health and Human Development · P50
Contact PI · $7.8M · Massachusetts General Hospital
2021–2027

Opioid Antagonism in Hypogonadotropic Hypogonadism
Principal investigator · Completed · Phase 1
Stephanie B. Seminara, MD
2025
Recall by Genotype: Neuropeptide Stimulation
Principal investigator · Terminated · Phase 1
Stephanie B. Seminara, MD
2023–2024
Dampening the Reproductive Axis With Continuous Kisspeptin
Principal investigator · Completed · Phase 1
Stephanie B. Seminara, MD
2023–2024
Kisspeptin Administration Subcutaneously to Patients With IHH
Principal investigator · Recruiting · Phase 2
Stephanie B. Seminara, MD
2023–2028