Research fellowship
2022-23 Sarnoff Fellow at the University of Pennsylvania, sponsored by Richard Kitsis and precepted by Zoltan Arany[6]
2022 to 2023
Journey
Education, training and research through time.
Undergraduate
Villanova University
Medical school
Albert Einstein College of Medicine
Residency
Hospital of the University of Pennsylvania
Fellowship
University of Pennsylvania
- Graduated in 2018
- Began after Villanova graduation in 2018; continued after 2019 MD enrollmentEmploymentNew York, NY
Research Assistant, Brady Laboratory of Genetically Encoded Small Molecules[10]
The institutional profile reports the start sequence and continuation into medical school but supplies no end date.
- MD attendance from 2019 to completion on May 23, 2024Medical schoolBronx, NY
MD education[2][5][10]
Albert Einstein College of Medicine
Einstein supports 2019 MD enrollment and 2024 MD completion. Penn later displays MD, PhD, but no available record establishes a PhD program, institution, dissertation, or dates; Einstein's commencement program does not mark Forelli among its MD-PhD graduates.
- 2020
2 attributed works
- Total Synthesis of Malacidin A by β-Hydroxyaspartic Acid Ligation-Mediated Cyclization and Absolute Structure Establishment.
Angewandte Chemie (International ed. in English)
- Synthetic-Bioinformatic Natural Product Antibiotics with Diverse Modes of Action.
Journal of the American Chemical Society
- Total Synthesis of Malacidin A by β-Hydroxyaspartic Acid Ligation-Mediated Cyclization and Absolute Structure Establishment.
- 2022
1 attributed work
- 2024
1 attributed work
- Histopathology and radiologic imaging for the confirmation of calciphylaxis in a diverse population: A retrospective cohort study.
Journal of the American Academy of Dermatology
- Histopathology and radiologic imaging for the confirmation of calciphylaxis in a diverse population: A retrospective cohort study.
- 2025
1 attributed work
- Off-target depletion of plasma tryptophan by allosteric inhibitors of BCKDK.
Molecular metabolism
- Off-target depletion of plasma tryptophan by allosteric inhibitors of BCKDK.
- Observed as a first-year fellow on September 4, 2026FellowshipPhiladelphia, PA
Cardiovascular Disease Fellowship, first-year fellow[2]
Penn's current-fellows page establishes the role and training year only; it does not establish the fellowship's full span.
- 2026
1 attributed work
- SGLT2 inhibitors activate pantothenate kinase in the human heart.
Science (New York, N.Y.) · First author
- SGLT2 inhibitors activate pantothenate kinase in the human heart.
- Dates not establishedResidencyPhiladelphia, PA
Internal Medicine Residency[2][4]
Hospital of the University of Pennsylvania
Penn sources identify the residency but do not provide dates.
Works appear by publication year. Their position does not establish where or when the underlying research was performed.
Education and training
Degrees, training periods and the milestones within them.
- Graduated in 2018
- MD attendance from 2019 to completion on May 23, 2024Medical schoolBronx, NY
MD education[2][5][10]
Albert Einstein College of Medicine
Einstein supports 2019 MD enrollment and 2024 MD completion. Penn later displays MD, PhD, but no available record establishes a PhD program, institution, dissertation, or dates; Einstein's commencement program does not mark Forelli among its MD-PhD graduates.
- Dates not establishedResidencyPhiladelphia, PA
Internal Medicine Residency[2][4]
Hospital of the University of Pennsylvania
Penn sources identify the residency but do not provide dates.
- Observed as a first-year fellow on September 4, 2026FellowshipPhiladelphia, PA
Cardiovascular Disease Fellowship, first-year fellow[2]
Penn's current-fellows page establishes the role and training year only; it does not establish the fellowship's full span.
Research
Research interests
Physical-organic chemistry of substituted bicyclooctanones[7]
2016
Research interests
Synthesis and physical-organic analysis of helminthosporol analogs[8]
2017
Research topic
Cardiometabolic mechanisms of SGLT2 inhibition in heart failure[9]
Publications
6 attributed works · 1 first author. Counts reflect resolved authorship and may be incomplete.
- 2026SGLT2 inhibitors activate pantothenate kinase in the human heart.Science (New York, N.Y.)first authorPMID 42658934
- 2025Off-target depletion of plasma tryptophan by allosteric inhibitors of BCKDK.Molecular metabolismPMID 40348014
- 2024Histopathology and radiologic imaging for the confirmation of calciphylaxis in a diverse population: A retrospective cohort study.Journal of the American Academy of DermatologyPMID 38513831
- 2022Lapcin, a potent dual topoisomerase I/II inhibitor discovered by soil metagenome guided total chemical synthesis.Nature communicationsPMID 35149673
- 2020Total Synthesis of Malacidin A by β-Hydroxyaspartic Acid Ligation-Mediated Cyclization and Absolute Structure Establishment.Angewandte Chemie (International ed. in English)PMID 32725837
- 2020Synthetic-Bioinformatic Natural Product Antibiotics with Diverse Modes of Action.Journal of the American Chemical SocietyPMID 32697091
Sources
Sources are listed once and connected to each accepted claim they support. Excerpts preserve the source language used in the review.
- [1]PubMed records
7 source claims · Reviewed Sep 5, 2026
Attributed work: Histopathology and radiologic imaging for the confirmation of calciphylaxis in a diverse population: A retrospective cohort study. | DOI 10.1016/j.jaad.2024.03.012 | PMID 38513831
July 2024
Histopathology and radiologic imaging for the confirmation of calciphylaxis in a diverse population: A retrospective cohort study.
Attributed work: Lapcin, a potent dual topoisomerase I/II inhibitor discovered by soil metagenome guided total chemical synthesis. | DOI 10.1038/s41467-022-28292-x | PMID 35149673
Feb 11, 2022
Lapcin, a potent dual topoisomerase I/II inhibitor discovered by soil metagenome guided total chemical synthesis.
Attributed work: Off-target depletion of plasma tryptophan by allosteric inhibitors of BCKDK. | DOI 10.1016/j.molmet.2025.102165 | PMID 40348014
July 2025
Off-target depletion of plasma tryptophan by allosteric inhibitors of BCKDK.
Attributed work: SGLT2 inhibitors activate pantothenate kinase in the human heart. | DOI 10.1101/2024.07.26.605401 | PMID 39091820
Jul 27, 2024
SGLT2 inhibitors activate pantothenate kinase in the human heart.
Attributed work: SGLT2 inhibitors activate pantothenate kinase in the human heart. | DOI 10.1126/science.aeh4856 | PMID 42658934
Aug 27, 2026
SGLT2 inhibitors activate pantothenate kinase in the human heart.
Attributed work: Synthetic-Bioinformatic Natural Product Antibiotics with Diverse Modes of Action. | DOI 10.1021/jacs.0c04376 | PMID 32697091
Aug 19, 2020
Synthetic-Bioinformatic Natural Product Antibiotics with Diverse Modes of Action.
Attributed work: Total Synthesis of Malacidin A by β-Hydroxyaspartic Acid Ligation-Mediated Cyclization and Absolute Structure Establishment. | DOI 10.1002/anie.202009092 | PMID 32725837
Nov 2, 2020
Total Synthesis of Malacidin A by β-Hydroxyaspartic Acid Ligation-Mediated Cyclization and Absolute Structure Establishment.
- [2]Reviewed current trainee roster
2 source claims · 6 journey details · Reviewed Sep 5, 2026
MD education: MD attendance from 2019 to completion on May 23, 2024. Einstein supports 2019 MD enrollment and 2024 MD completion. Penn later displays MD, PhD, but no available record establishes a PhD program, institution, dissertation, or dates; Einstein's commencement program does not mark Forelli among its MD-PhD graduates.
Penn roster displays MD, PhD: Observed on Penn's roster on September 4, 2026
Internal Medicine Residency: Dates not established. Penn sources identify the residency but do not provide dates.
Cardiovascular Disease Fellowship, first-year fellow: Observed as a first-year fellow on September 4, 2026. Penn's current-fellows page establishes the role and training year only; it does not establish the fellowship's full span.
The PhD credential is preserved as a Penn roster observation, not a verified degree history. Its institution, field, and dates remain unresolved.
Einstein's commencement program and Penn's residency and fellowship pages do not date the transition from MD completion through residency into fellowship.
Biographical context: Penn fellowship roster displays credential MD, PhD
Nicholas Forelli, MD, PhD
Fellowship: Cardiovascular Disease Fellowship, University of Pennsylvania
1st year fellows | Nicholas Forelli, MD, PhD
- [3]Penn CVI Trainee Research in Progress
1 source claim · Reviewed Sep 5, 2026
Biographical context: Presented Arany Lab work at Penn CVI Trainee Research in Progress
Oct 22, 2024
October 22, 2024 | Nicholas Forelli, MD | Arany Lab
- [4]Arany Lab members
2 source claims · 2 journey details · Reviewed Sep 5, 2026
Internal Medicine Residency: Dates not established. Penn sources identify the residency but do not provide dates.
Einstein's commencement program and Penn's residency and fellowship pages do not date the transition from MD completion through residency into fellowship.
Official headshot: Portrait
Residents | img source srcset=/aranylab/assets/image-cache/user-content/images/nick-forelli.8e331ca0.png alt=Nicholas Forelli | Nicholas Forelli | Internal Medicine Resident
Residency: Internal Medicine Residency, Hospital of the University of Pennsylvania
Nicholas Forelli | Internal Medicine Resident
- [5]Albert Einstein College of Medicine 2024 Commencement Program
2 source claims · 5 journey details · Reviewed Sep 5, 2026
BS in Biochemistry: Graduated in 2018. The Einstein profile identifies the degree field and graduation year; the commencement program independently names Villanova as the prior BS institution.
MD education: MD attendance from 2019 to completion on May 23, 2024. Einstein supports 2019 MD enrollment and 2024 MD completion. Penn later displays MD, PhD, but no available record establishes a PhD program, institution, dissertation, or dates; Einstein's commencement program does not mark Forelli among its MD-PhD graduates.
MD completed: Completed May 23, 2024
The PhD credential is preserved as a Penn roster observation, not a verified degree history. Its institution, field, and dates remain unresolved.
Einstein's commencement program and Penn's residency and fellowship pages do not date the transition from MD completion through residency into fellowship.
Medical school: Albert Einstein College of Medicine (MD)
Through May 23, 2024
CANDIDATES FOR DEGREES AND DIPLOMAS | Nicholas A. Forelli | B.S., Villanova University
Undergraduate education: Villanova University (BS; field not stated in commencement source)
Nicholas A. Forelli | B.S., Villanova University
- [6]2022-23 Sarnoff Fellows
1 source claim · 1 journey details · Reviewed Sep 5, 2026
Sarnoff Cardiovascular Research Fellowship: 2022-2023 fellowship cycle. The research fellowship occurred during medical school, with Richard Kitsis as sponsor and Zoltan Arany as Penn preceptor.
Research fellowship: 2022-23 Sarnoff Fellow at the University of Pennsylvania, sponsored by Richard Kitsis and precepted by Zoltan Arany
2022 to 2023
Nicholas Forelli | Medical School: Albert Einstein | Sponsor: Richard Kitsis, MD | Host Institution: University of Pennsylvania | Preceptor: Zoltan Arany, MD, PhD
- [7]Villanova Undergraduate Research Symposium 2016 Abstracts
1 source claim · Reviewed Sep 5, 2026
Research interests: Physical-organic chemistry of substituted bicyclooctanones
2016
A-11: Synthesis and observation of steric hindrance of substituted Bicyclo[3.2.1]octanones | Authors: Nicholas Forelli, Dr. Brian K. Ohta, and Dr. Eduard Casillas
- [8]Villanova Undergraduate Research Symposium 2017 Abstracts
1 source claim · Reviewed Sep 5, 2026
Research interests: Synthesis and physical-organic analysis of helminthosporol analogs
2017
A-14: Synthesis and Physical Organic Analysis of Analogs of Helminthosporol | Author: Nicholas Forelli
- [9]Nicholas Forelli Sarnoff Fellow abstract
1 source claim · Reviewed Sep 5, 2026
Research topic: Cardiometabolic mechanisms of SGLT2 inhibition in heart failure
Empagliflozin Mediates Acute and Chronic metabolic changes in a Cardiospecific mechanism of Action
- [10]Einstein Medical Student Nick Forelli Awarded a Sarnoff Research Fellowship
0 source claims · 5 journey details
BS in Biochemistry: Graduated in 2018. The Einstein profile identifies the degree field and graduation year; the commencement program independently names Villanova as the prior BS institution.
Research Assistant, Brady Laboratory of Genetically Encoded Small Molecules: Began after Villanova graduation in 2018; continued after 2019 MD enrollment. The institutional profile reports the start sequence and continuation into medical school but supplies no end date.
MD education: MD attendance from 2019 to completion on May 23, 2024. Einstein supports 2019 MD enrollment and 2024 MD completion. Penn later displays MD, PhD, but no available record establishes a PhD program, institution, dissertation, or dates; Einstein's commencement program does not mark Forelli among its MD-PhD graduates.
Enrolled in the MD program: Enrolled in 2019
Sarnoff Cardiovascular Research Fellowship: 2022-2023 fellowship cycle. The research fellowship occurred during medical school, with Richard Kitsis as sponsor and Zoltan Arany as Penn preceptor.
