Donald O’Rourke
Director, Human Brain Tumor Tissue Bank · Perelman School of Medicine at the University of Pennsylvania
Credentials: · · ·
History
- Present
Glioblastoma Translational Center of Excellence · Perelman School of Medicine at the University of Pennsylvania
PresentGlioblastoma Translational Center of Excellence (TCE) · University of Pennsylvania Health System
- Present
ACC Translational Center of Excellence in Glioblastoma · University of Pennsylvania Health System
- 1994–1995
Hospital
- 1979–1983
Harvard College
Research
IDH mutation impairs histone demethylation and results in a block to cell differentiation
Nature · 2012 · 1,631 citations
Science Translational Medicine · 2017 · First of 21 authors · 1,567 citations
The Lancet Oncology · 2017 · 932 citations
46 papers
42 papers
39 papers
31 papers
22 papers
19 papers
18 papers
16 papers
Grants
- 2026–2031
Real-Time Response Prediction to GBM CART Cell Therapy with Patient-Matched Organoids
National Cancer Institute · R01
Contact PI · $668.9K · University of Pennsylvania
- 2022–2026
Credentialing Next-Generation Human Glioma Models for Precision Therapeutics
National Cancer Institute · R01
PI · $2.8M · University of Alabama at Birmingham
- 2002–2019
Imaging Signatures of Genetic Mutations in Glioblastoma Using Machine Learning
National Institute of Neurological Disorders and Stroke · R01
PI · $1.6M · University of Pennsylvania
- 2001–2009
SHP2 and SIRP Modulate erbB Signals in Astrocytes
National Cancer Institute · R56
Contact PI · $273.6K · University of Pennsylvania
Clinical trials
- 2019–2021
CART-EGFRvIII + Pembrolizumab in GBM
Principal investigator · Completed · Phase 1
University of Pennsylvania
- 2016–2018
Principal investigator · Completed
University of Pennsylvania
- 2014–2018
Principal investigator · Terminated · Phase 1
University of Pennsylvania