Neal Rosen
Chair, Center for Mechanism-Based Therapy · New York Presbyterian Hospital
Credentials: · · ·
History
PresentCenter for Mechanism-Based Therapy · New York Presbyterian Hospital
Medical Oncology
Internal Medicine
Research
mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
Cancer Research · 2006 · Last of 12 authors · 2,177 citations
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
Nature · 2010 · Last of 5 authors · Corresponding · 1,523 citations
RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)
Nature · 2011 · 1,198 citations
83 papers · 10 as a fellow
29 papers · 3 as a fellow
- RY
21 papers
- HS
19 papers
- JB
19 papers
16 papers · 1 as a fellow
13 papers
11 papers
Grants
- 2007–2031
Targets for Therapy for Carcinomas of the Lung
National Cancer Institute · P01
Project lead · $3M · Sloan-Kettering Inst Can Research
- 2016–2023
Studies on Oncoprotein-Induced Feedback: Basic and Therapeutic Implications
National Cancer Institute · R35
Contact PI · $7.3M · Sloan-Kettering Inst Can Research
- 2001–2022
National Cancer Institute · P50
Project lead · $3.7M · Sloan-Kettering Inst Can Research
- 2002–2020
Program Project in Models of Breast Cancer
National Cancer Institute · P01
Project lead · $5M · Sloan-Kettering Inst Can Research
Clinical trials
- 2004–2008
Principal investigator · Completed · Phase 1, Phase 2
Memorial Sloan Kettering Cancer Center