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Sarat Chandarlapaty

Naddisy Foundation Chair in Breast Cancer Research at Memorial Sloan Kettering · New York Presbyterian Hospital

Credentials: · · · ·

History

New York Presbyterian Hospital
Present

Hematology and Medical Oncology
Memorial Sloan Kettering Cancer Center
2005–2008
New York Presbyterian Hospital
2002–2005
University of North Carolina at Chapel Hill
Wake Forest Univ Sch of Med
1998–2002

Research

OncoKB: A Precision Oncology Knowledge Base
JCO Precision Oncology · 2017 · 2,318 citations
Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer
Cancer Cell · 2011 · 1,033 citations
ESR1 ligand-binding domain mutations in hormone-resistant breast cancer
Nature Genetics · 2013 · Last of 18 authors · 1,006 citations

PR
Pedram Razavi
47 papers · 7 as a fellow
NR
Neal Rosen
29 papers
JB
José Baselga
28 papers
David Solit
26 papers
SM
Shanu Modi
25 papers
KJ
Komal Jhaveri
19 papers
LN
Larry Norton
19 papers
EB
Edi Brogi
17 papers
ML
Marc Ladanyi
16 papers
AS
Anton Safonov
15 papers · 3 as a fellow
DR
Dara Ross
15 papers
DH
David Hyman
14 papers

Grants

Overcoming Resistance to Targeted Therapy in Breast Cancer
National Cancer Institute · R35
Contact PI · $2.1M · Sloan-Kettering Inst Can Research
2025–2032
MSK SPORE in Genomic Instability in Breast Cancer
National Cancer Institute · P50
PI · $4M · Sloan-Kettering Inst Can Research
2020–2031
Targeting the Epidermal Growth Factor Receptor (EGFR) to Revert Trastuzumab Deruxtecan Resistance in HER2-Low Colorectal Cancer.
National Cancer Institute · R01
PI · $1M · Sloan-Kettering Inst Can Research
2025–2030
HER2-Mediated Delivery of Cytotoxic Agents in Solid Tumors
National Cancer Institute · R01
Contact PI · $2.3M · Sloan-Kettering Inst Can Research
2021–2025

Clinical trials

BYL719 Plus Letrozole or Exemestane for Patients With Hormone-Receptor Positive Locally-Advanced Unresectable or Metastatic Breast Cancer
Principal investigator · Completed · Phase 1
Memorial Sloan Kettering Cancer Center
2013–2022
Molecular Mechanisms of Clinical Resistance to Targeted Therapy Among Patients With Breast Cancer
Study chair · Completed
Memorial Sloan Kettering Cancer Center
2007–2026