Terence Flotte
Physician · Louisiana State University School of Medicine
Credentials: · · ·
History
Pediatric Pulmonology
Pediatrics
Research
Human Gene Therapy · 2008 · 814 citations
Proceedings of the National Academy of Sciences of the United States of America · 2008 · 580 citations
Proceedings of the National Academy of Sciences of the United States of America · 1993 · First of 9 authors · 442 citations
- CM
45 papers
21 papers
12 papers
- JC
11 papers
10 papers
- CC
10 papers · 6 as a fellow
10 papers
- JC
9 papers
Grants
- 2021–2031
Models and Gene Therapies for AAT Deficiency
National Heart, Lung, and Blood Institute · P01
Contact PI · $16.5M · Univ of Massachusetts Med Sch Worcester
- 2013–2023
Nuclease Free Gene Editing Approaches to Treat Alpha-1 Antitrypsin Disease
National Institute of Diabetes and Digestive and Kidney Diseases · R01
Contact PI · $3M · Univ of Massachusetts Med Sch Worcester
- 2016–2022
New Approaches to Gene Therapy for Alpha-1 Antitrypsin Deficiency
National Heart, Lung, and Blood Institute · P01
Contact PI · $11.3M · Univ of Massachusetts Med Sch Worcester
- 2002–2015
Preclinical & Phase I/II Trials of AAV-AAT Vectors
National Heart, Lung, and Blood Institute · R01
Contact PI · $3.6M · Univ of Massachusetts Med Sch Worcester
Clinical trials
- 2024–2028
Long-Term Follow-Up of Subjects Treated With AXO-AAV-GM2 for Tay-Sachs or Sandhoff Disease
Principal investigator · Active not recruiting
Terence Flotte
- 2021–2024
A Dose-escalation and Safety & Efficacy Study of AXO-AAV-GM2 in Tay-Sachs or Sandhoff Disease
Principal investigator · Terminated · Phase 1
Terence Flotte
- 2010–2015
Safety & Efficacy Study of rAAV1-CB-hAAT for Alpha-1 Antitrypsin Deficiency
Principal investigator · Completed · Phase 2
Beacon Therapeutics
- 2006–2015
Experimental Gene Transfer Procedure to Treat Alpha 1-Antitrypsin (AAT) Deficiency
Principal investigator · Completed · Phase 1
University of Massachusetts, Worcester